{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T11:02:56Z","timestamp":1784718176952,"version":"3.55.0"},"reference-count":38,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin. Pract.","Clinics and Practice"],"abstract":"<jats:p>Apert syndrome is a rare genetic disorder characterized by premature fusion of the cranial sutures, syndactyly of the extremities, and distinct craniofacial deformities. The condition results from mutations in the FGFR2 gene, which disrupt normal craniofacial growth and lead to complex functional and morphological abnormalities. Patients with Apert syndrome commonly present with stomatognathic abnormalities, which significantly affect oral function and facial development. The management of Apert syndrome requires a multidisciplinary therapeutic approach. Surgical treatment strategies are typically staged according to the patient\u2019s age and clinical severity. Early interventions focus on cranial vault expansion procedures, such as fronto-orbital advancement and posterior vault distraction osteogenesis, aiming to relieve intracranial pressure and improve cranial morphology. During childhood and adolescence, midface advancement techniques are commonly performed to address midfacial hypoplasia and associated functional impairments. Early diagnosis and appropriate surgical planning play a crucial role in preventing complications and improving the functional, aesthetic, and psychosocial outcomes of patients with Apert syndrome. This narrative review summarizes current evidence while highlighting areas of ongoing controversy, particularly regarding surgical sequencing, orthodontic management and the integration of digital technologies into multidisciplinary care.<\/jats:p>","DOI":"10.3390\/clinpract16070135","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T09:20:39Z","timestamp":1784712039000},"page":"135","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Apert Syndrome: Oral, Maxillofacial and Dental Management\u2014A Narrative Clinical Review"],"prefix":"10.3390","volume":"16","author":[{"given":"Nikolaos G. A.","family":"Kolomvos","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, School of Dentistry, National and Kapodistrian University of Athens, 2 Thivon Street, Goudi, Athens 11527, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6775-9562","authenticated-orcid":false,"given":"Thomai","family":"Papadaki","sequence":"additional","affiliation":[{"name":"Dental School, National and Kapodistrian University of Athens, 2 Thivon Street, Goudi, Athens 11527, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregoris","family":"Venetis","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, School of Dentistry, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"key":"ref_1","unstructured":"Karsonovich, T., and Patel, B.C. (2025, June 18). Apert Syndrome [Internet], Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK518993\/."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/jcu.22927","article-title":"Apert syndrome: A case report of prenatal ultrasound, postmortem cranial CT, and molecular genetic analysis","volume":"49","author":"Zhang","year":"2021","journal-title":"J. Clin. Ultrasound"},{"key":"ref_3","unstructured":"(2025, June 18). National Organization For Rare Disorders. Apert Syndrome [Internet]. Available online: https:\/\/rarediseases.org\/rare-diseases\/apert-syndrome\/."},{"key":"ref_4","first-page":"923","article-title":"Differential effects of FGFR2 mutations on syndactyly and cleft palate in Apert syndrome","volume":"58","author":"Slaney","year":"1996","journal-title":"Am. J. Hum. Genet."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.1016\/j.tripleo.2006.04.006","article-title":"Intraoral features of Apert\u2019s syndrome","volume":"103","author":"Letra","year":"2007","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod."},{"key":"ref_6","first-page":"58","article-title":"Treatment timing and multidisciplinary approach in Apert syndrome","volume":"6","author":"Fadda","year":"2015","journal-title":"Ann. Stomatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/SCS.0000000000007154","article-title":"Orthognathic Surgery in Craniosynostosis","volume":"32","author":"Ferri","year":"2021","journal-title":"J. Craniofac. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"82e","DOI":"10.1097\/PRS.0000000000003524","article-title":"What\u2019s New in Syndromic Craniosynostosis Surgery?","volume":"140","author":"Taylor","year":"2017","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.jcms.2016.06.001","article-title":"Apert syndrome: Surgical outcomes and perspectives","volume":"44","author":"Breik","year":"2016","journal-title":"J. Cranio-Maxillofac. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e1302022","DOI":"10.46900\/apn.v4i2(May-August).130","article-title":"Posterior vault distraction osteogenesis in Apert syndrome","volume":"4","author":"Ghizoni","year":"2022","journal-title":"Arch. Pediatr. Neurosurg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1055\/s-0034-1390171","article-title":"An update on midface advancement using le fort II and III distraction osteogenesis","volume":"28","author":"Tahiri","year":"2014","journal-title":"Semin. Plast. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"219e","DOI":"10.1097\/PRS.0b013e3182778882","article-title":"Correcting the typical apert face: Combining bipartition with monobloc distraction","volume":"131","author":"Greig","year":"2013","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_13","first-page":"e660","article-title":"Dental approach for apert syndrome in children: A systematic review","volume":"22","year":"2017","journal-title":"Med. Oral Patol. Oral Cir. Bucal"},{"key":"ref_14","first-page":"243","article-title":"The apert and crouzon syndromes: General and dental aspects and management in orthodontics and dentofacial orthopaedics: A review article","volume":"6","author":"Professor","year":"2020","journal-title":"Int. J. Appl. Dent. Sci."},{"key":"ref_15","first-page":"90","article-title":"Apert Syndrome: Report of a Case with Emphasis on Oral Manifestations","volume":"8","author":"Saberi","year":"2011","journal-title":"J. Dent."},{"key":"ref_16","first-page":"1184","article-title":"Long-term Management of a Patient with Apert Syndrome","volume":"22","author":"Horiuchi","year":"2021","journal-title":"J. Contemp. Dent. Pract."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"448E","DOI":"10.1097\/PRS.0000000000011035","article-title":"Evidence-Based Practices in Cleft Palate Surgery","volume":"153","author":"Applebaum","year":"2024","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1055\/s-0039-1698939","article-title":"Apert syndrome: A case report","volume":"6","author":"Ileri","year":"2012","journal-title":"Eur. J. Dent."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"S82","DOI":"10.1016\/j.ajodo.2012.01.003","article-title":"Craniofacial team management in Apert syndrome","volume":"141","author":"Oberoi","year":"2012","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15713\/ins.ijmdcr.168","article-title":"Dental treatment in a hospital setting for a patient with Apert syndrome: A case report","volume":"11","author":"Hogan","year":"2021","journal-title":"Int. J. Med. Dent. Case Rep."},{"key":"ref_21","first-page":"e17735","article-title":"Apert Syndrome: An Insight Into Dentofacial Features","volume":"13","author":"Jose","year":"2021","journal-title":"Cureus"},{"key":"ref_22","first-page":"1","article-title":"Prevalence and Patterns of Permanent Tooth Agenesis in Patients With Crouzon or Apert Syndrome: A Systematic Review and Meta-Analysis","volume":"29","author":"Ongkosuwito","year":"2025","journal-title":"Orthod. Craniofac. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"11089","DOI":"10.1007\/s12035-025-04902-9","article-title":"Insight into Apert Syndrome: Reporting on Six Patients and Increasing Awareness","volume":"62","author":"Afifi","year":"2025","journal-title":"Mol. Neurobiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1590\/S1678-77572006000600014","article-title":"Oral findings in patients with Apert syndrome","volume":"14","author":"Gomide","year":"2006","journal-title":"J. Appl. Oral Sci."},{"key":"ref_25","unstructured":"Adam, M.P., Bick, S., Mirzaa, G.M., Wallace, S.E., and Amemiya, A. (2019). Apert Syndrome. Gene Reviews\u00ae, University of Washington."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.jobcr.2022.04.002","article-title":"Apert Syndrome: Dental management considerations and objectives","volume":"12","author":"Droubi","year":"2022","journal-title":"J. Oral Biol. Craniofac. Res."},{"key":"ref_27","first-page":"173","article-title":"Oral health status of children with syndromic craniosynostosis","volume":"4","author":"Costa","year":"2006","journal-title":"Oral Health Prev. Dent."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1590\/S1678-77572009000100004","article-title":"Comparison of periodontal parameters in individuals with syndromic craniosynostosis","volume":"17","year":"2009","journal-title":"J. Appl. Oral Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e260724","DOI":"10.1136\/bcr-2024-260724","article-title":"Apert syndrome: Craniofacial challenges and clinical implications","volume":"17","author":"Singh","year":"2024","journal-title":"BMJ Case Rep."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1097\/SCS.0000000000002016","article-title":"Guideline for Care of Patients with the Diagnoses of Craniosynostosis: Working Group on Craniosynostosis","volume":"26","author":"Mathijssen","year":"2015","journal-title":"J. Craniofac. Surg."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e266714","DOI":"10.1136\/bcr-2025-266714","article-title":"Optimising anaesthetic management during fronto-orbital advancement in an infant with Apert syndrome","volume":"18","author":"Florendo","year":"2025","journal-title":"BMJ Case Rep."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jobcr.2016.07.002","article-title":"Apert syndrome with S252W FGFR2 mutation and characterization using Phenomizer: An Indian case report","volume":"7","author":"Kunwar","year":"2017","journal-title":"J. Oral Biol. Craniofac. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s40368-013-0105-9","article-title":"Cranio-maxillofacial, orthodontic and dental treatment in three patients with Apert syndrome","volume":"15","author":"Carpentier","year":"2014","journal-title":"Eur. Arch. Paediatr. Dent."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"\u010cverha, M., and Thurzo, A. (2026). Digital workflow and 3D printing of palato-lingual plates for robin sequence: Current concepts and future directions. Bratisl. Med. J.","DOI":"10.1007\/s44411-026-00654-7"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Meara John, G., Proctor, M.R., and Alonso, N. (2026). Innovations and Emerging Technologies in Craniofacial Surgery. Apert Syndrome: Comprehensive Care of the Patient and Family [Internet], Springer Nature.","DOI":"10.1007\/978-3-032-12551-4"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.bjps.2025.04.037","article-title":"Virtual surgical planning in craniomaxillofacial surgery: A systematic review and meta-analysis of accuracy, operative time, and cost-effectiveness","volume":"105","author":"Sharaf","year":"2025","journal-title":"J. Plast. Reconstr. Aesthetic Surg."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e7125","DOI":"10.1097\/GOX.0000000000007125","article-title":"Virtual Surgical Planning and Cutting Guides in Le Fort II Distraction With Zygomatic Repositioning","volume":"13","author":"Calzadilla","year":"2025","journal-title":"Plast. Reconstr. Surg. Glob. Open"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"D\u2019Albis, G., Forte, M., Stef, L., Feier, D.R., Garc\u00eda, V.D.F., Corsalini, M., and Capodiferro, S. (2025). A Digital Workflow for Virtual Articulator Mounting Using Face Scan and Facebow Capture: A Proof-of-Concept. Dent. J., 13.","DOI":"10.3390\/dj13080378"}],"container-title":["Clinics and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2039-7283\/16\/7\/135\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T10:23:13Z","timestamp":1784715793000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2039-7283\/16\/7\/135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,22]]},"references-count":38,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["clinpract16070135"],"URL":"https:\/\/doi.org\/10.3390\/clinpract16070135","relation":{},"ISSN":["2039-7283"],"issn-type":[{"value":"2039-7283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,22]]}}}