{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T10:18:09Z","timestamp":1788171489790,"version":"build-2803163510"},"reference-count":20,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin. Pract.","Clinics and Practice"],"abstract":"<jats:p>Background: Peyronie\u2019s Disease (PD) is a complex andrological condition that severely compromises patients\u2019 quality of life. While a novel formulation of hyaluronic acid (HA) has recently gained traction for treating the acute inflammatory phase, clinical evidence regarding its role in stable-phase (chronic) PD is lacking. We aimed to assess the therapeutic outcomes and safety profile of Perovial\u00ae, a specialized HA formulation, in patients with stable disease. Methods: A cohort of 47 patients with stable-phase PD was treated at a single andrological center between June and December 2025. The treatment protocol consisted of eight weekly injections targeted around the tunica albuginea plaque. Clinical efficacy was assessed 3 months post-treatment by comparing baseline data with the following outcome measures: change in penile curvature (\u0394\u00b0), the international index of erectile function (IIEF-5) score, Peyronie\u2019s Disease Questionnaire (PDQ) and Global Assessment of Peyronie\u2019s Disease (GAPD). Results: At the 3-month follow-up visit, a statistically significant improvement in penile curvature was registered in 35 out of 47 patients (\u0394\u00b0 \u2212 16) (p &lt; 0.001). All patients had a significant improvement from baseline in terms of IIEF (20 vs. 24; p &lt; 0.001) and in all PDQ domains. No major adverse events or complications were observed during the study period. At the GAPD questionnaire, 43 patients (91.2%) reported subjective improvement of penile curvature. Conclusions: Perilesional injection of Perovial\u00ae seems a promising intervention in patients with stable-phase PD in terms of penile curvature reduction and patient-reported quality of life improvement.<\/jats:p>","DOI":"10.3390\/clinpract16090162","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T09:21:19Z","timestamp":1788168079000},"page":"162","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Stable-Phase Peyronie\u2019s Disease: Have Perilesional Injections of Hyaluronic Acid Come of Age?"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7234-3526","authenticated-orcid":false,"given":"Tommaso","family":"Cai","sequence":"first","affiliation":[{"name":"Urology Division, Santa Chiara Regional and Teaching Hospital, Trentino Integrated University Health System (ASUIT), 38123 Trento, Italy"},{"name":"Interdepartmental Centre of Medical Sciences (CISMed), University of Trento, 38123 Trento, Italy"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"conceptualization","vocabulary":"credit"}]},{"given":"Daniele","family":"Tiscione","sequence":"additional","affiliation":[{"name":"Urology Division, Santa Chiara Regional and Teaching Hospital, Trentino Integrated University Health System (ASUIT), 38123 Trento, Italy"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"}]},{"given":"Marco","family":"Puglisi","sequence":"additional","affiliation":[{"name":"Urology Division, Santa Chiara Regional and Teaching Hospital, Trentino Integrated University Health System (ASUIT), 38123 Trento, Italy"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"}]},{"given":"Daniele","family":"Mattevi","sequence":"additional","affiliation":[{"name":"Urology Division, Santa Chiara Regional and Teaching Hospital, Trentino Integrated University Health System (ASUIT), 38123 Trento, Italy"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"data-curation","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6874-2904","authenticated-orcid":false,"given":"Simone","family":"Botti","sequence":"additional","affiliation":[{"name":"Urology Division, Santa Chiara Regional and Teaching Hospital, Trentino Integrated University Health System (ASUIT), 38123 Trento, Italy"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"data-curation","vocabulary":"credit"},{"role":"software","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2423-2933","authenticated-orcid":false,"given":"Tommaso","family":"Ceccato","sequence":"additional","affiliation":[{"name":"Urology Division, Santa Chiara Regional and Teaching Hospital, Trentino Integrated University Health System (ASUIT), 38123 Trento, Italy"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"data-curation","vocabulary":"credit"},{"role":"software","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3490-6460","authenticated-orcid":false,"given":"Truls Erik","family":"Bjerklund Johansen","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, University of Oslo, 0010 Oslo, Norway"},{"name":"Department of Urology, Oslo University Hospital, 0010 Oslo, Norway"},{"name":"Institute of Clinical Medicine, University of Aarhus, 8000 Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Mois\u00e9s da Silva, G.V., D\u00e1vila, F.J., Rosito, T.E., and Martins, F.E. 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