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Governed by internal clocks, it modulates gene expression through feedback loops involving Clock Genes (CGs), with the cycle initiated by CLOCK\u2013BMAL1 and NPAS2\u2013BMAL1 heterodimers. Disruptions in circadian rhythms have been linked to diseases including metabolic disorders, neurodegeneration, and cancer. CIPC (CLOCK-interacting pacemaker) has been studied as a negative regulator of the CLOCK\u2013BMAL1 complex, focusing on its role in cancer, particularly leukemias. Public datasets and bioinformatics tools were used to examine CIPC gene expression in healthy patients and acute myeloid leukemia (AML) samples. Our analysis revealed significant overexpression of CIPC in AML compared to healthy tissues (p &lt; 0.0001 ****). Additionally, survival analysis indicated significant differences in overall survival based on CIPC expression, with a log-rank test p-value = 0.014, suggesting that CIPC expression may affect overall patient survival. Altered CIPC expression may contribute to leukemogenesis by inhibiting circadian genes, which are often disrupted in leukemia. Furthermore, CIPC interacts with oncogenic pathways, including the MAPK\/ERK pathway, which is essential for cell proliferation. Additional studies are needed to validate these findings and explore the detailed role of CIPC in cancer development.<\/jats:p>","DOI":"10.3390\/clockssleep7030033","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T08:23:22Z","timestamp":1750839802000},"page":"33","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of the Circadian Rhythm Component Cipc (Clock-Interacting Pacemaker) in Leukemogenesis: A Literature Review and Bioinformatics Approach"],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3385-1653","authenticated-orcid":false,"given":"Leidivan Sousa","family":"da Cunha","sequence":"first","affiliation":[{"name":"Department of Medicine, Clinical Genetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Cear\u00e1, Fortaleza 60430-275, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz Maria Dias","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Department of Medicine, Clinical Genetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Cear\u00e1, Fortaleza 60430-275, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8432-4760","authenticated-orcid":false,"given":"Fl\u00e1via Melo Cunha","family":"de Pinho Pessoa","sequence":"additional","affiliation":[{"name":"Department of Medicine, Clinical Genetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Cear\u00e1, Fortaleza 60430-275, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caio Bezerra","family":"Machado","sequence":"additional","affiliation":[{"name":"Department of Medicine, Clinical Genetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Cear\u00e1, Fortaleza 60430-275, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deivide","family":"de Sousa Oliveira","sequence":"additional","affiliation":[{"name":"Department of Medicine, Clinical Genetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Cear\u00e1, Fortaleza 60430-275, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoel Odorico","family":"de Moraes Filho","sequence":"additional","affiliation":[{"name":"Department of Medicine, Clinical Genetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Cear\u00e1, Fortaleza 60430-275, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Elisabete Amaral","family":"de Moraes","sequence":"additional","affiliation":[{"name":"Department of Medicine, Clinical Genetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Cear\u00e1, Fortaleza 60430-275, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3451-6369","authenticated-orcid":false,"given":"Andr\u00e9 Salim","family":"Khayat","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Oncology Research Center, Federal University of Par\u00e1, Bel\u00e9m 66077-830, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5845-3481","authenticated-orcid":false,"given":"Caroline Aquino","family":"Moreira-Nunes","sequence":"additional","affiliation":[{"name":"Department of Medicine, Clinical Genetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Cear\u00e1, Fortaleza 60430-275, CE, Brazil"},{"name":"Department of Biological Sciences, Oncology Research Center, Federal University of Par\u00e1, Bel\u00e9m 66077-830, PA, Brazil"},{"name":"Brazilian Institute of Intelligence in Health, Research and Education, IBISPE, Fortaleza 60160-230, CE, Brazil"},{"name":"Clementino Fraga Group, Central Unity, Molecular Biology Laboratory, Fortaleza 60455-970, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.bj.2018.02.003","article-title":"The Discoveries of Molecular Mechanisms for the Circadian Rhythm: The 2017 Nobel Prize in Physiology or Medicine","volume":"41","author":"Huang","year":"2018","journal-title":"Biomed. 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