{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T23:57:29Z","timestamp":1791244649003,"version":"4.1.0"},"reference-count":20,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T00:00:00Z","timestamp":1739404800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CMTR"],"abstract":"<jats:p>Reconstruction of cranio-maxillofacial defects following ablative surgeries requires a comprehensive approach that balances functional restoration with aesthetic outcomes. Advances in computer-aided design and manufacturing (CAD\/CAM) technology have revolutionized this field, enabling precise preoperative planning, including 3D modeling, segmentation, and virtual resection planning. These methods allow for the production of patient-specific implants and surgical templates while facilitating the evaluation of treatment outcomes. CAD\/CAM technology offers numerous benefits, such as enhanced surgical accuracy, improved aesthetic results, reduced operative times, and the possibility of single-stage resection and reconstruction. However, limitations exist, including high costs, the need for specialized expertise, and dependency on accurate imaging data. This paper provides a surgeon-centric evaluation of the advantages and limitations of CAD\/CAM in cranio-maxillofacial reconstruction. The discussion encompasses the technological workflow, clinical applications, and recommendations for optimizing outcomes. Future perspectives highlight ongoing developments, such as integrating non-ionizing imaging techniques and expanding the applicability of virtual and augmented reality. By synthesizing technical advancements and clinical expertise, this review aims to establish practical guidelines for implementing CAD\/CAM technology in routine surgical practice.<\/jats:p>","DOI":"10.3390\/cmtr18010015","type":"journal-article","created":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T08:01:19Z","timestamp":1739433679000},"page":"15","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Patient-Specific Solutions for Cranial, Midface, and Mandible Reconstruction Following Ablative Surgery: Expert Opinion and a Consensus on the Guidelines and Workflow"],"prefix":"10.3390","volume":"18","author":[{"given":"Majeed","family":"Rana","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Buchbinder","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Mount Sinai Beth Israel, New York, NY 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9667-336X","authenticated-orcid":false,"given":"Gregorio","family":"Aniceto","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Surgery, University Hospital 12 de Octubre, 28041 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerson","family":"Mast","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Ludwig-Maximilians-University of Munich, 80539 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1024\/1661-8157\/a003185","article-title":"Die CAD\/CAM-Revolution in der kraniofazialen Rekonstruktion","volume":"108","author":"Wagner","year":"2019","journal-title":"Praxis"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/lary.24175","article-title":"Commentary on the role of expert opinion in developing evidence-based guidelines","volume":"124","author":"Eibling","year":"2014","journal-title":"Laryngoscope"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"S187","DOI":"10.1097\/BPO.0b013e318259f2ed","article-title":"Limitations of evidence-based medicine: The role of experience and expert opinion","volume":"32","author":"Wenger","year":"2012","journal-title":"J. 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