{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T20:50:54Z","timestamp":1778705454495,"version":"3.51.4"},"reference-count":46,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T00:00:00Z","timestamp":1748476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CMTR"],"abstract":"<jats:p>Objective: Trauma is a leading cause of enophthalmos, typically resulting from an increase in the volume of the bony orbit. The general consensus is that post-traumatic primary deformity repair should aim to restore the premorbid volume, shape, and cosmesis of the orbitozygomatic complex (OZC). This study aims to utilise novel three-dimensional (3D) printed patient-specific moulds to intraoperatively fabricate enophthalmos wedges and onlays using polymethylmethacrylate (PMMA) bone cement to reconstruct the OZC. Methods: A total of seven patients underwent digital surgical planning using Freeform software to virtually correct orbitozygomatic complex deformities guided by a design algorithm. Three-dimensionally printed nylon patient-specific moulds were used intraoperatively to fabricate enophthalmos wedges and\/or onlays using an industry-standard PMMA bone cement. Clinical examination and application of the proposed design algorithm determined that enophthalmos wedges were indicated for four patients, with one also requiring an onlay; and periorbital onlays were required for the three remaining patients. Results: Hertel exophthalmometry at a mean follow-up of 19.1 months demonstrated good outcomes in the correction of post-traumatic enophthalmos and hypoglobus and with patients reporting good subjective cosmetic results. Patients 5 and 7 had follow-up three-dimensional computed tomography (3D-CT) to confirm correct placement. Conclusion: The use of patient-specific PMMA wedges and onlays, fabricated intraoperatively with the aid of 3D-printed moulds, offers a reliable and effective approach for correcting post-traumatic enophthalmos and hypoglobus. This method allows for the restoration of orbital volume and anatomical contours, addressing both functional and aesthetic concerns. Our results demonstrate that this technique yields favourable outcomes.<\/jats:p>","DOI":"10.3390\/cmtr18020029","type":"journal-article","created":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T09:47:34Z","timestamp":1748512054000},"page":"29","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Intraoperative Fabrication of PMMA Patient-Specific Enophthalmos Wedges and Onlays for Post-Traumatic OZC Reconstruction"],"prefix":"10.3390","volume":"18","author":[{"given":"Layton","family":"Vosloo","sequence":"first","affiliation":[{"name":"Independent Researcher, Johannesburg 2000, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.5999\/aps.2012.39.1.11","article-title":"Correction of posttraumatic enophthalmos","volume":"39","author":"Hazani","year":"2012","journal-title":"Arch. Plast. Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1097\/00006534-198504000-00009","article-title":"Orbital volume measurements in enophthalmos using three-dimensional CT imaging","volume":"75","author":"Bite","year":"1985","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.survophthal.2007.06.009","article-title":"Diagnosis and management of enophthalmos","volume":"52","author":"Hamedani","year":"2007","journal-title":"Surv. Ophthalmol."},{"key":"ref_4","first-page":"251","article-title":"Management of posttraumatic enophthalmos","volume":"29","author":"Chen","year":"2006","journal-title":"Chang Gung Med. J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"361","DOI":"10.7181\/acfs.2019.00451","article-title":"Correction of post-traumatic enophthalmos with anatomical absorbable implant and iliac bone graft","volume":"20","author":"Choi","year":"2019","journal-title":"Arch. Craniofac. Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0094-1298(20)30702-1","article-title":"Deep orbital reconstruction for correction of post-traumatic enophthalmos","volume":"14","author":"Manson","year":"1987","journal-title":"Clin. Plast. Surg."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Xing, Y., Guo, Y., Ding, X., Li, J., and Lin, M. (2020). Eyelid malposition after orbital fracture surgery. Ann. Eye Sci., 5.","DOI":"10.21037\/aes-2020-es-06"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.joms.2022.01.002","article-title":"Classification and Management of Infra-orbital Rim Fractures","volume":"80","author":"Parameswaran","year":"2022","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.coms.2012.07.006","article-title":"Orbital Trauma","volume":"24","author":"Ellis","year":"2012","journal-title":"Oral Maxillofac. Surg. Clin. N. Am."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.2147\/OPTH.S216838","article-title":"Hertel exophthalmometer versus computed tomography scan in proptosis estimation in thyroid-associated orbitopathy","volume":"13","author":"Park","year":"2019","journal-title":"Clin. Ophthalmol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1615\/JLongTermEffMedImplants.v15.i6.60","article-title":"PMMA: An essential material in medicine and dentistry","volume":"15","author":"Frazer","year":"2005","journal-title":"J. Long Term Eff. Med. Implant."},{"key":"ref_12","unstructured":"Kretz, F., Scholtz, S., and Auffarth, G. (2024, January 06). Brief History of IOL Materials, 5 May 2014. Available online: https:\/\/theophthalmologist.com\/subspecialties\/a-brief-history-of-iol-materials."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.3928\/0147-7447-20021201-21","article-title":"The science of bone cement: A historical review","volume":"25","author":"DiMaio","year":"2002","journal-title":"Orthopedics"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"E19","DOI":"10.3171\/2014.2.FOCUS13561","article-title":"Materials used in cranioplasty: A history and analysis","volume":"36","author":"Shah","year":"2014","journal-title":"Neurosurg. Focus"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1243\/095441103762597683","article-title":"Fatigue strength of PMMA bone cement mixed with gentamicin and barium sulphate vs pure PMMA","volume":"217","author":"Baleani","year":"2003","journal-title":"Proc. Inst. Mech. Eng. H"},{"key":"ref_16","first-page":"374","article-title":"The effect of adding 10% of barium sulphate radiopacifier on the mechanical behaviour of acrylic bone cement","volume":"34","author":"Massimiliano","year":"2010","journal-title":"Fatigue Fract. Eng. Mater. Struct."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Wall, V., Nguyen, T.H., Nguyen, N., and Tran, P.A. (2021). Controlling Antibiotic Release from Polymethylmethacrylate Bone Cement. Biomedicines, 9.","DOI":"10.3390\/biomedicines9010026"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s002640050235","article-title":"Pharmacokinetics, uses, and limitations of vancomycin-loaded bone cement","volume":"22","author":"Chohfi","year":"1998","journal-title":"Int. Orthop. SICOT"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1097\/BOT.0000000000000454","article-title":"Dead Space Management After Orthopaedic Trauma: Tips, Tricks, and Pitfalls","volume":"30","author":"Gage","year":"2016","journal-title":"J. Orthop. Trauma"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S0094-1298(20)31046-4","article-title":"Strategies for the treatment of enophthalmos","volume":"24","author":"Grant","year":"1997","journal-title":"Clin. Plast. Surg."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.ijom.2016.04.007","article-title":"Can customized implants correct enophthalmos and delayed diplopia in post-traumatic orbital deformities? A volumetric analysis","volume":"45","author":"Pedemonte","year":"2016","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_22","unstructured":"Jugadoe, B. (2012). The Surgical Management of Orbital Management of Orbital Fractures: A Case Series. [Master\u2019s Thesis, University of the Witwatersrand]. Available online: http:\/\/hdl.handle.net\/10539\/12638."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.ijom.2014.12.003","article-title":"Controversies in orbital reconstruction--II. Timing of post-traumatic orbital reconstruction: A systematic review","volume":"44","author":"Dubois","year":"2015","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1016\/j.joms.2009.08.029","article-title":"Evaluation of the application of computer-aided shape-adapted fabricated titanium mesh for mirroring-reconstructing orbital walls in cases of late post-traumatic enophthalmos","volume":"68","author":"Zhang","year":"2010","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1076\/orbi.21.1.27.2598","article-title":"Diplopia and enophthalmos after surgical repair of blowout fracture","volume":"21","author":"Beatty","year":"2002","journal-title":"Orbit"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/sj\/dmfr\/4600551","article-title":"Dimensions and volumes of the orbit and orbital fat in posttraumatic enophthalmos","volume":"29","author":"Ramieri","year":"2000","journal-title":"Dentomaxillofac. Radiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1080\/01676830.2019.1691607","article-title":"Post-traumatic enophthalmos secondary to orbital fat atrophy: A volumetric analysis","volume":"39","author":"Cohen","year":"2019","journal-title":"Orbit"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1016\/j.joms.2018.03.015","article-title":"Correction of Delayed Traumatic Enophthalmos Using Customized Orbital Implants","volume":"76","year":"2018","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_29","unstructured":"(2019). Application of Risk Management to Medical Devices (Standard No. ISO14971:2019). Available online: https:\/\/www.iso.org\/obp\/ui\/#iso:std:iso:14971:ed-3:v1:en."},{"key":"ref_30","unstructured":"(2017). Additive Manufacturing\u2014General Principles\u2014Requirements for Purchased AMparts (Standard No. ISO52901:2017). Available online: https:\/\/www.iso.org\/obp\/ui\/en\/#iso:std:iso-astm:52901:ed-1:v1:en."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1900091","DOI":"10.1002\/marc.201900091","article-title":"Polyamide\/PEG Blends as Biocompatible Biomaterials for the Convenient Regulation of Cell Adhesion and Growth","volume":"40","author":"Winnacker","year":"2019","journal-title":"Macromol. Rapid Commun."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"3368","DOI":"10.1002\/pat.5372","article-title":"Nylon-A material introduction and overview for biomedical applications","volume":"32","author":"Shakiba","year":"2021","journal-title":"Polym. Adv. Technol."},{"key":"ref_33","unstructured":"(2021). Biological Evaluation of Medical Devices\u2014Part 10: Tests for Skin Sensitization (Standard No. ISO 10993-10:2021). Available online: https:\/\/www.iso.org\/obp\/ui\/en\/#iso:std:iso:10993:-10:ed-4:v1:en."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1590\/1678-5150-pvb-5776","article-title":"Biocompatibility of polyamide 12 intramedullary rod after humeral consolidation in white Plymouth Rock birds","volume":"38","author":"Dias","year":"2018","journal-title":"Pesq. Vet. Bras."},{"key":"ref_35","unstructured":"National Museum of American History (2025, May 11). Sutures. Available online: https:\/\/americanhistory.si.edu\/collections\/object\/nmah_738063."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"67","DOI":"10.5312\/wjo.v4.i2.67","article-title":"Polymethylmethacrylate bone cements and additives: A review of the literature","volume":"4","author":"Arora","year":"2013","journal-title":"World J. Orthop."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s11604-008-0269-0","article-title":"Effects of barium concentration on the radiopacity and biomechanics of bone cement: Experimental study","volume":"26","author":"Makita","year":"2008","journal-title":"Radiat. Med."},{"key":"ref_38","unstructured":"(2025, May 25). Antibiotic-eluting Medical Devices for Various Applications. Available online: https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/palacos."},{"key":"ref_39","unstructured":"U.S. Food Drug Administration (2025, May 09). Custom Device Exemption 21 CFR\u00a78123(b), U.S. Code of Federal Regulations. Updated 1 April 2024, Available online: https:\/\/www.ecfr.gov\/current\/title-21\/chapter-I\/subchapter-H\/part-812."},{"key":"#cr-split#-ref_40.1","unstructured":"European Union (2017). Regulation"},{"key":"#cr-split#-ref_40.2","unstructured":"(EU) 2017\/745 of the European Parliament and of the Council of 5 April 2017 on medical devices. Off. J. Eur. Union, L117, 1-175."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1097\/SCS.0b013e3180534361","article-title":"Posttraumatic enophthalmos: Etiology, principles of reconstruction, and correction","volume":"19","author":"Clauser","year":"2008","journal-title":"J. Craniofac. Surg."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.bjps.2008.08.060","article-title":"Treatment of enophthalmos using corrective osteotomy with concomitant cartilage-graft implantation","volume":"63","author":"Lee","year":"2010","journal-title":"J. Plast. Reconstr. Aesthet. Surg."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1055\/s-0030-1269769","article-title":"Pearls of orbital trauma management","volume":"24","author":"Roth","year":"2010","journal-title":"Semin. Plast. Surg."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Dinu, C., Tamas, T., Agrigoroaei, G., Stoia, S., Opris, H., Bran, S., Armencea, G., and Manea, A. (2022). Prospective Evaluation of Intraorbital Soft Tissue Atrophy after Posttraumatic Bone Reconstruction: A Risk Factor for Enophthalmos. J. Pers. Med., 12.","DOI":"10.20944\/preprints202207.0017.v1"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1163\/157075611X617102","article-title":"An ancestral axial twist explains the contralateral forebrain and the optic chiasm in vertebrates","volume":"62","author":"Osse","year":"2012","journal-title":"Anim. Biol."}],"container-title":["Craniomaxillofacial Trauma &amp; Reconstruction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1943-3883\/18\/2\/29\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:43:17Z","timestamp":1760031797000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1943-3883\/18\/2\/29"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,29]]},"references-count":46,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["cmtr18020029"],"URL":"https:\/\/doi.org\/10.3390\/cmtr18020029","relation":{},"ISSN":["1943-3883"],"issn-type":[{"value":"1943-3883","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,29]]}}}