{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:38:05Z","timestamp":1787027885168,"version":"build-2736575974"},"reference-count":45,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T00:00:00Z","timestamp":1756512000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CMTR"],"abstract":"<jats:p>Alcohol Use Disorder (AUD) is common among patients with maxillofacial trauma. Conventional perioperative care recommends complete abstinence. However, abrupt cessation can lead to Alcohol Withdrawal Syndrome (AWS), negatively impacting psychological well-being and compliance. This randomized controlled pilot study evaluated the effectiveness of Monitored Therapeutic Alcohol Administration (MTAA) in reducing perioperative stress and enhancing quality of life without impairing fracture healing. Twenty-four adult male patients with AUD and isolated facial fractures requiring surgery were enrolled. They were assigned to either an intervention group (n = 12) receiving MTAA\u2014oral alcohol at 0.5 g\/kg\/day for two weeks\u2014or a control group (n = 12) undergoing complete abstinence. Outcomes were assessed over six weeks, including stress (Zung Self-Rating Depression Scale), quality of life (Oral Health Impact Profile-14), soft tissue healing (Landry\u2019s Index), and hard tissue healing (Moed\u2019s Scale, serum osteocalcin). The MTAA group showed significantly reduced stress and improved quality of life (p &lt; 0.001). Healing outcomes were comparable between groups, with no significant differences in soft tissue indices, osteocalcin levels, or radiographic scores. MTAA appears to be a safe and effective strategy to manage AWS-related distress and improve postoperative recovery, offering a practical alternative to strict abstinence in the surgical management of patients with AUD.<\/jats:p>","DOI":"10.3390\/cmtr18030037","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T08:23:38Z","timestamp":1756801418000},"page":"37","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of Therapeutic Alcohol Administration on Perioperative Quality of Life (QoL) and Fracture Healing in Patients with Alcohol Use Disorder Undergoing Surgery for Maxillofacial Trauma\u2014A Randomized Pilot Trial"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9930-3292","authenticated-orcid":false,"given":"Elavenil","family":"Panneerselvam","sequence":"first","affiliation":[{"name":"Department of Oral & Maxillofacial Surgery, SRM Dental College, SRM Institute of Science & Technology, Ramapuram Campus, Chennai 600089, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajkumar","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Department of Oral & Maxillofacial Pathology & Microbiology, SRM Dental College, SRM Institute of Science & Technology, Ramapuram Campus, Chennai 600089, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0939-3342","authenticated-orcid":false,"given":"Jaikumar","family":"Velayudham","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Government Medical College, Vellore 632011, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1080\/08897077.2019.1671936","article-title":"Underreporting of Alcohol Use in Trauma Patients: A Retrospective Analysis","volume":"42","author":"Hoonpongsimanont","year":"2021","journal-title":"Subst. 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