{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T01:49:51Z","timestamp":1777081791389,"version":"3.51.4"},"reference-count":62,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CMTR"],"abstract":"<jats:p>This meta-review evaluated the possibility of more specified recommendations in antibiotic treatment through a narrowed focus on facial trauma. The aim was to analyze the effect of different regimens of antibiotic in treatment of skeletal trauma to the face. The knowledge mapping was based on existing systematic reviews (SRs) on trials specified in a PICO: Participants (P): Adults and children, diagnosed with fractures to the facial skeleton. Interventions (I): Antibiotic intervention. Comparator (C): Placebo, no antibiotics. Outcomes (O): Postoperative infection, pain, re-operation, other complications, healing deficiencies, (Oral) Health related Quality of Life, removal of osteosynthesis, adverse reactions. The literature search in PubMed, The Cochrane Library, and Web of Science according to PRISMA resulted in 1487 records. A COVIDENCE selection process resulted in 29 articles retrieved and read in full text revealing 10 articles eligible for evaluated according to ROBIS. Three SRs were considered to have low risk of bias and constituted the final evidence evaluation. The meta-review of these SRs did not provide sufficient support for prolonged antibiotic treatment after surgical intervention of midfacial fractures in comparison with antibiotics only the first day postoperatively. No support for antibiotic treatment for conservatively managed fractures alone was found. This review is limited by a relatively low number of included SRs. However, tendencies in outcomes suggests a restricted duration of antibiotics in treatment of facial fractures.<\/jats:p>","DOI":"10.3390\/cmtr18040048","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T17:32:01Z","timestamp":1762191121000},"page":"48","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Importance of Antibiotics in Facial Fracture Treatment\u2014A Systematic Meta-Review"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0838-5737","authenticated-orcid":false,"given":"Martin","family":"Bengtsson","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, University Hospital of Sk\u00e5ne, 221 85 Lund, Sweden"},{"name":"Department of Clinical Sciences, Faculty of Medicine, Lund University, 222 22 Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5248-9202","authenticated-orcid":false,"given":"Aron","family":"Naimi-Akbar","sequence":"additional","affiliation":[{"name":"Health Technology Assessment-Odontology (HTA-O), Faculty of Odontology, Malm\u00f6 University, 205 06 Malm\u00f6, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joakim","family":"Johansson-Berggren","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, University Hospital of Sk\u00e5ne, 221 85 Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5994-299X","authenticated-orcid":false,"given":"Sebastian","family":"Dybeck-Udd","sequence":"additional","affiliation":[{"name":"Medical Unit of Plastic Surgery and Oral and Maxillofacial Surgery, Department for Oral and Maxillofacial Surgery and Jaw Orthopedics, Karolinska University Hospital, 171 65 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikael","family":"Magnusson","sequence":"additional","affiliation":[{"name":"Department of Specialist Dentistry, Oral and Maxillofacial Surgery, Colloseum and Smile AB, 167 51 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7008-3126","authenticated-orcid":false,"given":"Bodil","family":"Lund","sequence":"additional","affiliation":[{"name":"Medical Unit of Plastic Surgery and Oral and Maxillofacial Surgery, Department for Oral and Maxillofacial Surgery and Jaw Orthopedics, Karolinska University Hospital, 171 65 Stockholm, Sweden"},{"name":"Department of Dental Medicine, Karolinska Institute, 141 57 Huddinge, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,3]]},"reference":[{"key":"ref_1","first-page":"CD012603","article-title":"Systemic antibiotic prophylaxis for preventing infectious complications in maxillofacial trauma surgery","volume":"2017","author":"Alsharif","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_2","first-page":"873","article-title":"Microbiologic and antibiotic aspects of infections in the oral and maxillofacial region","volume":"37","author":"Greenberg","year":"1979","journal-title":"J. Oral. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.bjoms.2020.09.020","article-title":"Antibiotic prophylaxis in oral and maxillofacial surgery: A systematic review","volume":"59","author":"Milic","year":"2021","journal-title":"Br. J. Oral Maxillofac. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.coms.2021.08.015","article-title":"Current Concepts in Prophylactic Antibiotics in Oral and Maxillofacial Surgery","volume":"34","author":"Dammling","year":"2022","journal-title":"Oral Maxillofac. Surg. Clin. North Am."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e380","DOI":"10.4317\/medoral.26368","article-title":"Impact of long-term vs. short-term and single day vs. single dose of antibiotic prophylaxis in reducing infection rates after orthognathic surgery: A systematic review and meta-analysis","volume":"29","author":"Tang","year":"2024","journal-title":"Med. Oral Patol. Oral Y Cir. Bucal"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.ijom.2018.09.011","article-title":"Prevention and detection of prosthetic temporomandibular joint infections-update","volume":"48","author":"Mercuri","year":"2019","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1089\/sur.2020.107","article-title":"Surgical Infection Society Guidelines for Antibiotic Use in Patients with Traumatic Facial Fractures","volume":"22","author":"Forrester","year":"2021","journal-title":"Surg. Infect."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"S64","DOI":"10.1111\/clr.12675","article-title":"The patient undergoing implant therapy. Summary and consensus statements. The 4th EAO Consensus Conference 2015","volume":"26","author":"Klinge","year":"2015","journal-title":"Clin. Oral Implants Res."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Torof, E., Morrissey, H., and Ball, P.A. (2023). Antibiotic Use in Dental Implant Procedures: A Systematic Review and Meta-Analysis. Medicina, 59.","DOI":"10.3390\/medicina59040713"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1002\/lary.24364","article-title":"Are prophylactic antibiotics useful in the management of facial fractures?","volume":"124","author":"Morris","year":"2014","journal-title":"Laryngoscope"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ijom.2023.08.001","article-title":"Antibiotic prophylaxis in the prevention of dry socket and surgical site infection after lower third molar extraction: A network meta-analysis","volume":"53","author":"Figueiredo","year":"2024","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/0030-4220(93)90005-O","article-title":"Side effects and complications associated with third molar surgery","volume":"76","author":"Chiapasco","year":"1993","journal-title":"Oral Surg. Oral Med. Oral Pathol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1016\/j.joms.2015.07.025","article-title":"Risk Factors for Postoperative Infections After Dental Implant Placement: A Case-Control Study","volume":"73","author":"Figueiredo","year":"2015","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s15010-019-01303-8","article-title":"A systematic review of latest evidence for antibiotic prophylaxis and therapy in oral and maxillofacial surgery","volume":"47","author":"Blatt","year":"2019","journal-title":"Infection"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.ijom.2020.09.024","article-title":"Antibiotics in orthognathic surgery: A retrospective analysis and identification of risk factors for postoperative infection","volume":"50","author":"Verstraete","year":"2021","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1089\/sur.2019.149","article-title":"No Reduction in Surgical Site Infection Obtained with Post-Operative Antibiotics in Facial Fractures, Regardless of Duration or Anatomic Location: A Systematic Review and Meta-Analysis","volume":"21","author":"Delaplain","year":"2020","journal-title":"Surg. Infect."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Goormans, F., Coropciuc, R., Vercruysse, M., Spriet, I., Willaert, R., and Politis, C. (2022). Systemic Antibiotic Prophylaxis in Maxillofacial Trauma: A Scoping Review and Critical Appraisal. Antibiotics, 11.","DOI":"10.3390\/antibiotics11040483"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/lary.27210","article-title":"Postoperative prophylactic antibiotics for facial fractures: A systematic review and meta-analysis","volume":"129","author":"Habib","year":"2019","journal-title":"Laryngoscope"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.oooo.2021.12.135","article-title":"An evidence-based approach to antibiotic use in maxillofacial trauma","volume":"134","author":"Michel","year":"2022","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.joms.2023.03.017","article-title":"Limited Efficacy of Empiric Antibiotics for Pediatric Facial Fractures","volume":"81","author":"Tucker","year":"2023","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.jcms.2023.09.005","article-title":"Surgical site infections in maxillofacial trauma surgery-Single-dose versus prolonged antibiotic prophylaxis","volume":"51","author":"Gaessler","year":"2023","journal-title":"J. Craniomaxillofac. Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0140-6736(21)02724-0","article-title":"Global burden of bacterial antimicrobial resistance in 2019: A systematic analysis","volume":"399","author":"Murray","year":"2022","journal-title":"Lancet"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1093\/jac\/dkad128","article-title":"\u201bIf you want to go far, go together\u2019-Community-based behaviour change interventions to improve antibiotic use: A systematic review of quantitative and qualitative evidence","volume":"78","author":"Ghiga","year":"2023","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Meier, H., Spinner, K., Crump, L., Kuenzli, E., Schuepbach, G., and Zinsstag, J. (2022). State of Knowledge on the Acquisition, Diversity, Interspecies Attribution and Spread of Antimicrobial Resistance between Humans, Animals and the Environment: A Systematic Review. Antibiotics, 12.","DOI":"10.3390\/antibiotics12010073"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1055\/s-0034-1378187","article-title":"Antibiotics and facial fractures: Evidence-based recommendations compared with experience-based practice","volume":"8","author":"Mundinger","year":"2015","journal-title":"Craniomaxillofac. Trauma Reconstr."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1097\/SAP.0000000000000135","article-title":"The Role of Postoperative Antibiotics in Mandible Fractures: A Systematic Review of the Literature","volume":"75","author":"Shridharani","year":"2015","journal-title":"Ann. Plast. Surg."},{"key":"ref_27","first-page":"775","article-title":"Using the Methodology of Systematic Review of Reviews for Evidence-Based Medicine","volume":"29","author":"Hasanpoor","year":"2019","journal-title":"Ethiop. J. Health Sci."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Liberati, A., Altman, D.G., Tetzlaff, J., Mulrow, C., Gotzsche, P.C., Ioannidis, J.P., Clarke, M., Devereaux, P.J., Kleijnen, J., and Moher, D. (2009). The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: Explanation and elaboration. PLoS Med., 6.","DOI":"10.2427\/5768"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"A12","DOI":"10.7326\/ACPJC-1995-123-3-A12","article-title":"The well-built clinical question: A key to evidence-based decisions","volume":"123","author":"Richardson","year":"1995","journal-title":"ACP J. Club"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jclinepi.2015.06.005","article-title":"ROBIS: A new tool to assess risk of bias in systematic reviews was developed","volume":"69","author":"Whiting","year":"2016","journal-title":"J Clin Epidemiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e519","DOI":"10.1016\/j.surge.2020.12.009","article-title":"Review of prophylactic prescribing of antibiotics during the management of fractured mandibles","volume":"19","author":"Chaudhry","year":"2021","journal-title":"Surgeon"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1016\/j.bjoms.2021.01.018","article-title":"Use of antibiotics in traumatic mandibular fractures: A systematic review and meta-analysis","volume":"59","author":"Dawoud","year":"2021","journal-title":"Br. J. Oral Maxillofac. Surg."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/j.joms.2010.02.059","article-title":"Use of antibiotics in the treatment of mandible fractures: A systematic review","volume":"69","author":"Kyzas","year":"2011","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1001\/jamaoto.2019.0879","article-title":"Evaluation of Prolonged vs Short Courses of Antibiotic Prophylaxis Following Ear, Nose, Throat, and Oral and Maxillofacial Surgery: A Systematic Review and Meta-analysis","volume":"145","author":"Oppelaar","year":"2019","journal-title":"JAMA Otolaryngol. Head Neck Surg."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.cden.2009.08.004","article-title":"Use of prophylactic antibiotics in preventing infection of traumatic injuries","volume":"53","author":"Abubaker","year":"2009","journal-title":"Dent. Clin. North Am."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1016\/j.joms.2006.02.032","article-title":"A systematic review of prophylactic antibiotics in the surgical treatment of maxillofacial fractures","volume":"64","author":"Andreasen","year":"2006","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1097\/SCS.0000000000008432","article-title":"Algorithmic Approach to Antibiotic Prophylaxis for Traumatic Craniomaxillofacial Injuries","volume":"33","author":"Caruso","year":"2022","journal-title":"J. Craniofac. Surg."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e124","DOI":"10.1097\/TA.0000000000002589","article-title":"Review of facial trauma management","volume":"88","author":"Choi","year":"2020","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Cicuttin, E., Sartelli, M., Scozzafava, E., Tartaglia, D., Cremonini, C., Brevi, B., Ramacciotti, N., Musetti, S., Strambi, S., and Podda, M. (2022). Antibiotic Prophylaxis in Torso, Maxillofacial, and Skin Traumatic Lesions: A Systematic Review of Recent Evidence. Antibiotics, 11.","DOI":"10.3390\/antibiotics11020139"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.fsc.2015.04.006","article-title":"Evidence-Based Facial Fracture Management","volume":"23","author":"Doerr","year":"2015","journal-title":"Facial Plast. Surg. Clin. North Am."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e7234","DOI":"10.5867\/medwave.2018.04.7233","article-title":"Are postoperative prophylactic antibiotics effective for orbital fracture?","volume":"18","author":"Gheza","year":"2018","journal-title":"Medwave"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Grillo, R., Brozoski, M.A., Moreira, S.B., da Silva, Y.S., Borba, A.M., and da Gra\u00e7a Nacl\u00e9rio-Homem, M. (2024). Antibiotic prophylaxis for animal inflicted maxillofacial injuries: A systematic review and meta-analysis. Front. Oral Maxillofac. Med., 6.","DOI":"10.21037\/fomm-23-18"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/j.1600-9657.2006.00499.x","article-title":"Effect of early or delayed treatment upon healing of mandibular fractures: A systematic literature review","volume":"24","author":"Hermund","year":"2008","journal-title":"Dent. Traumatol."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Kreutzer, K., Storck, K., and Weitz, J. (2014). Current evidence regarding prophylactic antibiotics in head and neck and maxillofacial surgery. Biomed. Res. Int., 2014.","DOI":"10.1155\/2014\/879437"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"S100","DOI":"10.1016\/S0750-7658(05)81784-8","article-title":"Antibiotic prophylaxis in ORL surgery and oral medicine","volume":"13","author":"Legent","year":"1994","journal-title":"Ann. Fr. Anesth. Reanim."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1136\/emj.20.1.66-a","article-title":"Antibiotics in orbital floor fractures","volume":"20","author":"Martin","year":"2003","journal-title":"Emerg. Med. J."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.coms.2017.06.002","article-title":"Controversies in Maxillofacial Trauma","volume":"29","author":"Meara","year":"2017","journal-title":"Oral Maxillofac. Surg. Clin. North Am."},{"key":"ref_48","first-page":"S264","article-title":"Prevention of infections associated with combat-related eye, maxillofacial, and neck injuries","volume":"71","author":"Petersen","year":"2011","journal-title":"J. Trauma"},{"key":"ref_49","first-page":"S265","article-title":"Prevention and management of infections associated with combat-related head and neck injuries","volume":"64","author":"Petersen","year":"2008","journal-title":"J. Trauma"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1089\/fpsam.2023.0123","article-title":"Utility of Antibiotic Use in Pediatric Facial Fractures: A Systematic Review","volume":"26","author":"Tucker","year":"2024","journal-title":"Facial Plast. Surg. Aesthet. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e116","DOI":"10.4317\/medoral.25530","article-title":"Systematic mapping review of interventions to prevent blood loss, infection and relapse in orthognathic surgery","volume":"28","author":"Bendersky","year":"2023","journal-title":"Med. Oral Patol. Oral Cir. Bucal."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.ijom.2022.10.009","article-title":"Complications of total temporomandibular joint replacement: A systematic review and meta-analysis","volume":"52","author":"Rios","year":"2023","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.jcms.2018.02.004","article-title":"Which antibiotic regimen prevents implant failure or infection after dental implant surgery? A systematic review and meta-analysis","volume":"46","author":"Arteagoitia","year":"2018","journal-title":"J. Craniomaxillofac. Surg."},{"key":"ref_54","first-page":"e123","article-title":"What are the risk factors for postoperative infections of third molar extraction surgery: A retrospective clinical study?","volume":"24","author":"Sukegawa","year":"2019","journal-title":"Med. Oral Patol. Oral Cir. Bucal."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1002\/JPER.18-0024","article-title":"Postoperative infections after dental implant placement: Variables associated with increased risk of failure","volume":"89","author":"Figueiredo","year":"2018","journal-title":"J. Periodontol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1080\/00016357.2020.1751273","article-title":"Effect of governmental strategies on antibiotic prescription in dentistry","volume":"78","author":"Lund","year":"2020","journal-title":"Acta Odontol. Scand."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Naimi-Akbar, A., Hultin, M., Klinge, A., Klinge, B., Tranaeus, S., and Lund, B. (2018). Antibiotic prophylaxis in orthognathic surgery: A complex systematic review. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0191161"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1136\/bmj.309.6954.597","article-title":"Rationale for systematic reviews","volume":"309","author":"Mulrow","year":"1994","journal-title":"BMJ"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1471-1842.2009.00848.x","article-title":"A typology of reviews: An analysis of 14 review types and associated methodologies","volume":"26","author":"Grant","year":"2009","journal-title":"Health Info. Libr. J."},{"key":"ref_60","first-page":"635","article-title":"Review Typology: The Basic Types of Reviews for Synthesizing Evidence for the Purpose of Knowledge Translation","volume":"27","author":"Samnani","year":"2017","journal-title":"J. Coll. Physicians Surg. Pak"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1097\/XEB.0000000000000055","article-title":"Summarizing systematic reviews: Methodological development, conduct and reporting of an umbrella review approach","volume":"13","author":"Aromataris","year":"2015","journal-title":"Int. J. Evid. Based Healthc."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Bastian, H., Glasziou, P., and Chalmers, I. (2010). Seventy-five trials and eleven systematic reviews a day: How will we ever keep up?. PLoS Med., 7.","DOI":"10.1371\/journal.pmed.1000326"}],"container-title":["Craniomaxillofacial Trauma &amp; Reconstruction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1943-3883\/18\/4\/48\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T18:06:47Z","timestamp":1762193207000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1943-3883\/18\/4\/48"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,3]]},"references-count":62,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["cmtr18040048"],"URL":"https:\/\/doi.org\/10.3390\/cmtr18040048","relation":{},"ISSN":["1943-3883"],"issn-type":[{"value":"1943-3883","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,3]]}}}