{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T15:06:55Z","timestamp":1779376015147,"version":"3.53.1"},"reference-count":34,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CMTR"],"abstract":"<jats:p>Orbital fractures account for up to 16% of all facial fractures. Surgical intervention for these fractures depends on several factors, including globe displacement. This case-control study aimed to quantify the effects of orbital reconstruction on the three-dimensional globe position after orbital trauma. Pre- and post-operative radiological data of 29 cases (27 patients, with two patients requiring reintervention) with an orbital fracture were analyzed. The contralateral, unaffected orbits of the same patients served as the control group. This study used a recently validated method employing semi-automatic registration algorithms to measure globe displacement after trauma and its post-operative change. The statistical analysis, performed using the Mann\u2013Whitney U test, showed significant globe position restoration in the anterior\u2013posterior (2.15 mm, p \u2264 0.001) and medial\u2013lateral (1.34 mm, p \u2264 0.001) directions, as well as in overall three-dimensional Euclidean distance (3.04 mm, p = 0.014) after surgery. The repositioning was clinically relevant in 62% of the cases, indicating that the three-dimensional globe repositioning was 2 mm or more with a positive clinical impact. Additionally, it was important to note that both the number of fractured walls and fractures of the inferomedial strut significantly affected globe repositioning after trauma. This finding highlights the importance of accurately considering the fracture pattern in surgical planning, as a better understanding of globe displacement following orbital trauma could enhance patient selection, surgical planning, and clinical outcomes.<\/jats:p>","DOI":"10.3390\/cmtr19020025","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T13:53:24Z","timestamp":1779371604000},"page":"25","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Three-Dimensional Globe Repositioning Following Orbital Reconstruction Independent of Bony Landmarks and Fracture Pattern Associations"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3561-9076","authenticated-orcid":false,"given":"Aaron","family":"De Poortere","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, University Hospitals Leuven, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1275-2771","authenticated-orcid":false,"given":"Kathia","family":"Dubron","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, University Hospitals Leuven, 3000 Leuven, Belgium"},{"name":"OMFS IMPATH Research Group, Department of Imaging & Pathology, University Hospitals Leuven, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine","family":"Neyt","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, University Hospitals Leuven, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3461-0363","authenticated-orcid":false,"given":"Reinhilde","family":"Jacobs","sequence":"additional","affiliation":[{"name":"OMFS IMPATH Research Group, Department of Imaging & Pathology, University Hospitals Leuven, 3000 Leuven, Belgium"},{"name":"Department of Dental Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6309-3791","authenticated-orcid":false,"given":"Eman","family":"Shaheen","sequence":"additional","affiliation":[{"name":"OMFS IMPATH Research Group, Department of Imaging & Pathology, University Hospitals Leuven, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1610-6988","authenticated-orcid":false,"given":"Robin","family":"Willaert","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, University Hospitals Leuven, 3000 Leuven, Belgium"},{"name":"OMFS IMPATH Research Group, Department of Imaging & Pathology, University Hospitals Leuven, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.cxom.2019.05.007","article-title":"Management of Orbital Fractures","volume":"27","author":"Kholaki","year":"2019","journal-title":"Atlas Oral Maxillofac. Surg. Clin. N. Am."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e93","DOI":"10.1016\/j.bjoms.2020.07.001","article-title":"Prevalence and severity of orbital blowout fractures","volume":"58","author":"Khojastepour","year":"2020","journal-title":"Br. J. Oral Maxillofac. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.coms.2012.07.006","article-title":"Orbital trauma","volume":"24","author":"Ellis","year":"2012","journal-title":"Oral Maxillofac. Surg. Clin. N. Am."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Desai, A., Dendukuri, G., and Naik, M. (2025). Globe Intussusception Following Orbital Trauma: Case Series and Review of Literature. Craniomaxillofac. Trauma Reconstr., 18.","DOI":"10.3390\/cmtr18040044"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1177\/19433875211026430","article-title":"Controversies and Contemporary Management of Orbital Floor Fractures","volume":"15","author":"Patel","year":"2022","journal-title":"Craniomaxillofac. Trauma Reconstr."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"238","DOI":"10.4103\/IJO.IJO_2803_23","article-title":"Association of fracture type with enophthalmos and intraorbital volume correction in orbital fractures: A computed tomographic study","volume":"73","author":"Parameswaran","year":"2025","journal-title":"Indian J. Ophthalmol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/00002341-200209000-00007","article-title":"The inferomedial orbital strut: An anatomic and radiographic study","volume":"18","author":"Kim","year":"2002","journal-title":"Ophthalmic Plast. Reconstr. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1177\/0194599816630722","article-title":"Orbital Decompression in the Endoscopic Age: The Modified Inferomedial Orbital Strut","volume":"154","author":"Yao","year":"2016","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.survophthal.2007.06.009","article-title":"Diagnosis and Management of Enophthalmos","volume":"52","author":"Hamedani","year":"2007","journal-title":"Surv. Ophthalmol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1097\/IOP.0000000000000437","article-title":"Axial Globe Position Measurement: A Prospective Multicenter Study by the International Thyroid Eye Disease Society","volume":"32","author":"Bingham","year":"2016","journal-title":"Ophthalmic Plast. Reconstr. Surg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.bjoms.2019.11.020","article-title":"Use of CAD-based pre-bent implants reduces theatre time in orbital floor reconstruction: Results of a prospective study","volume":"58","author":"Schwertner","year":"2020","journal-title":"Br. J. Oral Maxillofac. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1136\/bjo.78.8.618","article-title":"Prediction of enophthalmos by computed tomography after \u2018blow out\u2019 orbital fracture","volume":"78","author":"Whitehouse","year":"1994","journal-title":"Br. J. Ophthalmol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1007\/s00417-020-04631-w","article-title":"Three-dimensional characterisation of the globe position in the orbit","volume":"258","author":"Willaert","year":"2020","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"ref_14","first-page":"e19","article-title":"Evaluation of Globe Position Asymmetry in Endocrine Orbitopathy Patients and a Control Group\u2014A Computed Tomography-Based 3D Cephalometric Analysis","volume":"23","author":"Hierl","year":"2023","journal-title":"Eplasty"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1097\/IOP.0b013e31815eb7ce","article-title":"Prediction of enophthalmos by computer-based volume measurement of orbital fractures in a Korean population","volume":"24","author":"Ahn","year":"2008","journal-title":"Ophthalmic Plast. Reconstr. Surg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/ajpa.1330860307","article-title":"Euclidean distance matrix analysis: A coordinate-free approach for comparing biological shapes using landmark data","volume":"86","author":"Lele","year":"1991","journal-title":"Am. J. Phys. Anthropol."},{"key":"ref_17","unstructured":"Shah, S.S., and Patel, B.C. (2026). Enophthalmos. StatPearls, StatPearls Publishing."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1097\/01.iop.0000226865.22184.6a","article-title":"When is enophthalmos \u201csignificant\u201d?","volume":"22","author":"Koo","year":"2006","journal-title":"Ophthalmic Plast. Reconstr. Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.jcms.2018.01.007","article-title":"Is there more to the clinical outcome in posttraumatic reconstruction of the inferior and medial orbital walls than accuracy of implant placement and implant surface contouring? A prospective multicenter study to identify predictors of clinical outcome","volume":"46","author":"Zimmerer","year":"2018","journal-title":"J. Cranio-Maxillofac. Surg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1097\/PRS.0000000000010284","article-title":"Are We Overoperating on Isolated Orbital Floor Fractures?","volume":"152","author":"Billig","year":"2023","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"De Ruiter, B.J., Kotha, V.S., Lalezar, F.D., Swanson, M.A., Kumar, A.R., Barmettler, A., Prendes, M.A., and Davidson, E.H. (Plast. Reconstr. Surg., 2022). The Orbital Index: A novel comprehensive quantitative tool for prediction of delayed enophthalmos in orbital floor fracture management, Plast. Reconstr. Surg., in press.","DOI":"10.1097\/PRS.0000000000009428"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"100346","DOI":"10.1016\/j.adoms.2022.100346","article-title":"Fracture size greater than fifty percent of the orbital floor, as an indication for orbital repair, leads to overtreatment in isolated orbital floor fractures","volume":"8","author":"Watkins","year":"2022","journal-title":"Adv. Oral Maxillofac. Surg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1097\/00006534-199906000-00005","article-title":"Pure orbital blowout fracture: New concepts and importance of medial orbital blowout fracture","volume":"103","author":"Burm","year":"1999","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Choi, A., Sisson, A., Olson, K., and Sivam, S. (Facial Plast. Surg. Aesthetic Med., 2022). Predictors of Delayed Enophthalmos After Orbital Fractures: A Systematic Review, Facial Plast. Surg. Aesthetic Med., in press.","DOI":"10.1089\/fpsam.2021.0177"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1952.e1","DOI":"10.1016\/j.joms.2018.04.013","article-title":"Reconstructing a Traumatic Empty Orbit: Principles, Difficulties of Treatment, and Literature Review","volume":"76","author":"Stathopoulos","year":"2018","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1111\/joa.13136","article-title":"Restoration of the inferomedial orbital strut using a standardized three-dimensional printing implant","volume":"236","author":"Kim","year":"2020","journal-title":"J. Anat."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.cxom.2020.11.003","article-title":"Advanced Diagnostics and Three-dimensional Virtual Surgical Planning in Orbital Reconstruction","volume":"29","author":"Schreurs","year":"2021","journal-title":"Atlas Oral Maxillofac. Surg. Clin. N. Am."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.cxom.2020.11.006","article-title":"Intraoperative Feedback and Quality Control in Orbital Reconstruction: The Past, the Present, and the Future","volume":"29","author":"Schreurs","year":"2021","journal-title":"Atlas Oral Maxillofac. Surg. Clin. N. Am."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"101683","DOI":"10.1016\/j.jormas.2023.101683","article-title":"Accuracy of surgical navigation for patient-specific reconstructions of orbital fractures: A systematic review and meta-analysis","volume":"125","author":"Verbist","year":"2023","journal-title":"J. Stomatol. Oral Maxillofac. Surg."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Dubron, K., Verbist, M., Jacobs, R., Olszewski, R., Shaheen, E., and Willaert, R. (2023). Augmented and Virtual Reality for Preoperative Trauma Planning, Focusing on Orbital Reconstructions: A Systematic Review. J. Clin. Med., 12.","DOI":"10.3390\/jcm12165203"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1038\/s41598-025-85154-4","article-title":"Validation of mixed reality in planning orbital reconstruction with patient-specific implants","volume":"15","author":"Dubron","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.ijom.2020.07.027","article-title":"Semi-automatic magnetic resonance imaging based orbital fat volumetry: Reliability and correlation with computed tomography","volume":"50","author":"Willaert","year":"2021","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s11548-015-1254-6","article-title":"Orbital volume analysis: Validation of a semi-automatic software segmentation method","volume":"11","author":"Jansen","year":"2016","journal-title":"Int. J. Comput. Assist. Radiol. Surg."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1167\/iovs.07-1030","article-title":"A new and validated CT-based method for the calculation of orbital soft tissue volumes","volume":"49","author":"Regensburg","year":"2008","journal-title":"Investig. Ophthalmol. Vis. Sci."}],"container-title":["Craniomaxillofacial Trauma &amp; Reconstruction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1943-3883\/19\/2\/25\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T14:27:16Z","timestamp":1779373636000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1943-3883\/19\/2\/25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,21]]},"references-count":34,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["cmtr19020025"],"URL":"https:\/\/doi.org\/10.3390\/cmtr19020025","relation":{},"ISSN":["1943-3883"],"issn-type":[{"value":"1943-3883","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,21]]}}}