{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:47:33Z","timestamp":1760233653960,"version":"build-2065373602"},"reference-count":26,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T00:00:00Z","timestamp":1612742400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>The pandemic of SARS-CoV-2 is a serious global challenge affecting millions of people worldwide. Cancer patients are at risk for infection exposure and serious complications. A prompt diagnosis of SARS-CoV-2 infection is crucial for the timely adoption of isolation measures and the appropriate management of cancer treatments. In lung cancer patients the symptoms of infection 19 may resemble those exhibited by the underlying oncologic condition, possibly leading to diagnostic overlap and delays. Moreover, cancer patients might display a prolonged positivity of nasopharyngeal RT-PCR assays for SARS-CoV-2, causing long interruptions or delay of cancer treatments. However, the association between the positivity of RT-PCR assays and the patient\u2019s infectivity remains uncertain. We describe the case of a patient with non-small cell lung cancer, and a severe ab extrinseco compression of the trachea, whose palliative radiotherapy was delayed because of the prolonged positivity of nasopharyngeal swabs for SARS-CoV-2. The patient did not show clinical symptoms suggestive of active infection, but the persistent positivity of RT-PCR assays imposed the continuation of isolation measures and the delay of radiotherapy for over two months. Finally, the negative result of SARS-CoV-2 viral culture allowed us to verify the absence of viral activity and to rule out the infectivity of the patient, who could finally continue her cancer treatment.<\/jats:p>","DOI":"10.3390\/curroncol28010083","type":"journal-article","created":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T04:18:50Z","timestamp":1612844330000},"page":"847-852","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prolonged SARS-CoV-2-RNA Detection from Nasopharyngeal Swabs in an Oncologic Patient: What Impact on Cancer Treatment?"],"prefix":"10.3390","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6924-6306","authenticated-orcid":false,"given":"Anna","family":"Ferrari","sequence":"first","affiliation":[{"name":"Infectious Diseases Unit, Azienda Ospedale Universit\u00e0 di Padova, 35128 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Trevenzoli","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Azienda Ospedale Universit\u00e0 di Padova, 35128 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lolita","family":"Sasset","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Azienda Ospedale Universit\u00e0 di Padova, 35128 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Di Liso","sequence":"additional","affiliation":[{"name":"Medical Oncology 2, Istituto Oncologico Veneto IRCCS, 35128 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toni","family":"Tavian","sequence":"additional","affiliation":[{"name":"Department of Medicine, Geriatric Clinic, Universit\u00e0 di Padova, 35128 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Rossi","sequence":"additional","affiliation":[{"name":"Microbiology Department, Azienda Ospedale Universit\u00e0 di Padova, 35128 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugenia","family":"Di Meco","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Azienda Ospedale Universit\u00e0 di Padova, 35128 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2869-2945","authenticated-orcid":false,"given":"Anna Maria","family":"Cattelan","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Azienda Ospedale Universit\u00e0 di Padova, 35128 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,2,8]]},"reference":[{"key":"ref_1","unstructured":"European Centre for Disease Prevention and Control (2020). COVID-19 Situation Update Worldwide, as of 12 October 2020, ECDC. Available online: https:\/\/www.ecdc.europa.eu\/en\/geographical-distribution-2019-ncov-cases."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/S1470-2045(20)30309-0","article-title":"Clinical characteristics and risk factors associated with COVID-19 disease severity in patients with cancer in Wuhan, China: A multicentre, retrospective, cohort study","volume":"21","author":"Tian","year":"2020","journal-title":"Lancet Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1002\/jmv.25972","article-title":"Clinical characteristics and outcomes of cancer patients with COVID-19","volume":"92","author":"Yang","year":"2020","journal-title":"J. Med. Virol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/S2213-2600(20)30170-3","article-title":"Challenges in lung cancer therapy during the COVID-19 pandemic","volume":"8","author":"Peters","year":"2020","journal-title":"Lancet Respir. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1001\/jamaoncol.2020.0980","article-title":"SARS-CoV-2 Transmission in Patients with Cancer at a Tertiary Care Hospital in Wuhan, China","volume":"6","author":"Yu","year":"2020","journal-title":"JAMA Oncol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1016\/j.annonc.2020.07.010","article-title":"Managing cancer patients during the COVID-19 pandemic: An ESMO multidisciplinary expert consensus","volume":"31","author":"Lamarre","year":"2020","journal-title":"Ann. Oncol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.3201\/eid2611.203219","article-title":"SARS-CoV-2 Virus Culture and Subgenomic RNA for Respiratory Specimens from Patients with Mild Coronavirus Disease","volume":"26","author":"Perera","year":"2020","journal-title":"Emerg. Infect. Dis."},{"key":"ref_8","unstructured":"World Health Association (2021, January 10). Antigen-Detection in the Diagnosis of SARS-CoV-2 Infection Using Rapid Immunoassays. Interim Guidance. Available online: https:\/\/www.who.int\/publications\/i\/item\/antigen-detection-in-the-diagnosis-of-sars-cov-2infection-using-rapid-immunoassays."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1093\/cid\/ciaa638","article-title":"Predicting Infectious Severe Acute Respiratory Syndrome Coronavirus 2 from Diagnostic Samples","volume":"71","author":"Bullard","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1016\/j.cell.2020.10.049","article-title":"Case Study: Prolonged Infectious SARS-CoV-2 Shedding from an Asymptomatic Immunocompromised Individual with Cancer","volume":"183","author":"Avanzato","year":"2020","journal-title":"Cell"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Corman, V.M., Landt, O., Kaiser, M., Molenkamp, R., Meijer, A., Chu, D.K., Bleicker, T., Br\u00fcnink, S., Schneider, J., and Schmidt, M.L. (2020). Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR. Eurosurveillance, 25.","DOI":"10.2807\/1560-7917.ES.2020.25.3.2000045"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Gautret, P., Lagier, J.C., Parola, P., Hoang, V.T., Meddeb, L., Mailhe, M., Doudier, B., Courjon, J., Giordanengo, V., and Vieira, V.E. (2020). Hydroxychloroquine and azithromycin as a treatment of COVID-19: Results of an open-label non-randomized clinical trial. Int. J. Antimicrob. Agents, 56.","DOI":"10.1101\/2020.03.16.20037135"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"85","DOI":"10.5501\/wjv.v5.i2.85","article-title":"Determination of 50% endpoint titer using a simple formula","volume":"5","author":"Ramakrishnan","year":"2016","journal-title":"World J. Virol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Moujaess, E., Kourie, H.R., and Ghosn, M. (2020). Cancer patients and research during COVID-19 pandemic: A systematic review of current evidence. Crit. Rev. Oncol., 150.","DOI":"10.1016\/j.critrevonc.2020.102972"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Addeo, A., and Friedlaender, A. (2020). Cancer and COVID-19: Unmasking their ties. Cancer Treat. Rev., 88.","DOI":"10.1016\/j.ctrv.2020.102041"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"481","DOI":"10.5694\/mja2.50607","article-title":"Managing haematology and oncology patients during the COVID -19 pandemic: Interim consensus guidance","volume":"212","author":"Weinkove","year":"2020","journal-title":"Med. J. Aust."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e1834","DOI":"10.3201\/eid2608.201097","article-title":"Prolonged Persistence of SARS-CoV-2 RNA in Body Fluids","volume":"26","author":"Sun","year":"2020","journal-title":"Emerg. Infect. Dis."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1002\/jmv.25855","article-title":"False negative of RT-PCR and prolonged nucleic acid conversion in COVID-19: Rather than recurrence","volume":"92","author":"Xiao","year":"2020","journal-title":"J. Med. Virol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.jinf.2020.10.009","article-title":"The duration of infectiousness of individuals infected with SARS-CoV-2","volume":"81","author":"Walsh","year":"2020","journal-title":"J. Infect."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1093\/infdis\/jix490","article-title":"The Crux of Ebola Diagnostics","volume":"216","author":"Strong","year":"2017","journal-title":"J. Infect. Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s11912-020-00934-7","article-title":"COVID-19 and Cancer: A Comprehensive Review","volume":"22","author":"Gosain","year":"2020","journal-title":"Curr. Oncol. Rep."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1007\/s10096-020-03913-9","article-title":"Viral RNA load as determined by cell culture as a management tool for discharge of SARS-CoV-2 patients from infectious disease wards","volume":"39","author":"Andreani","year":"2020","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_23","unstructured":"European Centre for Disease Prevention and Control (2020). Options for the Use of Rapid Antigen Tests for COVID-19 in the EU\/EEA and the UK, ECDC. Available online: https:\/\/www.ecdc.europa.eu\/sites\/default\/files\/documents\/Options-use-of-rapid-antigen-tests-for-COVID-19_0.pdf."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1080\/22221751.2020.1756699","article-title":"Different longitudinal patterns of nucleic acid and serology testing results based on disease severity of COVID-19 patients","volume":"9","author":"Yongchen","year":"2020","journal-title":"Emerg. Microbes Infect."},{"key":"ref_25","unstructured":"World Health Organization (2021, January 10). Criteria for releasing COVID-19 patients from isolation. Scientific brief. Available online: https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/332451\/WHO-2019-nCoV-Sci_Brief-Discharge_From_Isolation-2020.1-eng.pdf."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.ijrobp.2020.03.007","article-title":"Letter from Italy: First practical indications for radiation therapy departments during COVID-19 outbreak","volume":"107","author":"Filippi","year":"2020","journal-title":"Int. J. Radiat. Oncol. Biol. 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