{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T03:14:35Z","timestamp":1783566875198,"version":"3.55.0"},"reference-count":16,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,5,7]],"date-time":"2021-05-07T00:00:00Z","timestamp":1620345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Approximately 20% of renal cell carcinoma (RCC) is diagnosed because of paraneoplastic manifestations. RCC has been associated with a large variety of paraneoplastic syndromes (PNS), but it is rarely associated with PNS vasculitis. We present a case of a previously healthy male who presented with systemic vasculitis; bitemporal headaches, diplopia, polyarthritis, palpable purpura, tongue lesion, peri-orbital edema, scleritis, chondritis and constitutional symptoms. He was subsequently found to have oligometastatic RCC. Both his primary lesion and site of oligometastasis were treated with stereotactic radiotherapy (SBRT) and resulted in the resolution of his vasculitis, as well as sustained oncologic response. This is the first case to demonstrate that effective sustained treatment for PNS vasculitis due to oligometastatic RCC is possible with SBRT.<\/jats:p>","DOI":"10.3390\/curroncol28030162","type":"journal-article","created":{"date-parts":[[2021,5,7]],"date-time":"2021-05-07T10:06:12Z","timestamp":1620381972000},"page":"1744-1750","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Stereotactic Radiotherapy in the Treatment of Paraneoplastic Vasculitis in Oligometastatic Renal Cell Carcinoma"],"prefix":"10.3390","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2664-0105","authenticated-orcid":false,"given":"Laura","family":"Burgess","sequence":"first","affiliation":[{"name":"Department of Radiology, Division of Radiation Oncology, University of Ottawa, 501 Smyth Road, Ottawa, ON K1H8L6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marissa","family":"Keenan","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Rheumatology, University of Ottawa, 501 Smyth Road, Ottawa, ON K1H8L6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7525-5660","authenticated-orcid":false,"given":"Alan Liang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Ottawa, 501 Smyth Road, Ottawa, ON K1H8L6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiefer","family":"Lypka","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Ottawa, 501 Smyth Road, Ottawa, ON K1H8L6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9084-6872","authenticated-orcid":false,"given":"Delvina","family":"Hasimja Saraqini","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Ottawa, 501 Smyth Road, Ottawa, ON K1H8L6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Urology, University of Ottawa, 501 Smyth Road, Ottawa, ON K1H8L6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Martin","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Ottawa, 501 Smyth Road, Ottawa, ON K1H8L6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Morash","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Urology, University of Ottawa, 501 Smyth Road, Ottawa, ON K1H8L6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Watterson","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Urology, University of Ottawa, 501 Smyth Road, Ottawa, ON K1H8L6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Canil","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Medical Oncology, University of Ottawa, 501 Smyth Road, Ottawa, ON K1H8L6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"MacRae","sequence":"additional","affiliation":[{"name":"Department of Radiology, Division of Radiation Oncology, University of Ottawa, 501 Smyth Road, Ottawa, ON K1H8L6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S1078-1439(01)00185-5","article-title":"Mode of presentation of renal cell carcinoma provides prognostic information","volume":"7","author":"Lee","year":"2002","journal-title":"Urol. 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Rheumatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1111\/j.1529-8019.2010.01367.x","article-title":"Paraneoplastic vasculitis and paraneoplastic vascular syndromes","volume":"23","author":"Buggiani","year":"2010","journal-title":"Dermatol. Ther."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1097\/MD.0000000000000009","article-title":"The Spectrum of Paraneoplastic Cutaneous Vasculitis in a Defined Population Incidence and Clinical Features","volume":"92","author":"Loricera","year":"2013","journal-title":"Medicine"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Tsimafeyeu, I., Leonenko, V., Kuznetsov, V., Semenkova, E., Bondarenko, A., and Demidov, L. (2019). Paraneoplastic vasculitis in patients with metastatic renal cell carcinoma. Cancer Rep., 2.","DOI":"10.1002\/cnr2.1142"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1080\/20009666.2019.1703374","article-title":"Polyarteritis Nodosa: An unusual case of paraneoplastic process in renal cell carcinoma","volume":"10","author":"Ahmed","year":"2020","journal-title":"J. Community Hosp. Intern. Med. Perspect."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Massucci, M., Mollica, V., Rizzo, A., Ventrella, L., Maggio, I., Manuzzi, L., Gatto, L., Brandi, G., and Massari, F. (2021). Encephalic Leukocytoclastic Vasculitis during Treatment with Sunitinib for Renal Cell Carcinoma: A Case Report. 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