{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T09:01:22Z","timestamp":1781082082527,"version":"3.54.1"},"reference-count":46,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T00:00:00Z","timestamp":1625443200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Objective: This review aims to provide a summary of the clinical indications and limitations of PET imaging with different radiotracers, including 18F-fluorodeoxyglucose (18F-FDG) and other radiopharmaceuticals, in pediatric neuro-oncology, discussing both supratentorial and infratentorial tumors, based on recent literature (from 2010 to present). Methods: A literature search of the PubMed\/MEDLINE database was carried out searching for articles on the use of PET in pediatric brain tumors. The search was updated until December 2020 and limited to original studies published in English after 1 January 2010. Results: 18F-FDG PET continues to be successfully employed in different settings in pediatric neuro-oncology, including diagnosis, grading and delineation of the target for stereotactic biopsy, estimation of prognosis, evaluation of recurrence, treatment planning and assessment of treatment response. Nevertheless, non-18F-FDG tracers, especially amino acid analogues seem to show a better performance in each clinical setting. Conclusions: PET imaging adds important information in the diagnostic work-up of pediatric brain tumors. International or national multicentric studies are encouraged in order to collect larger amount of data.<\/jats:p>","DOI":"10.3390\/curroncol28040226","type":"journal-article","created":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T22:02:04Z","timestamp":1625522524000},"page":"2481-2495","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["The Role of PET in Supratentorial and Infratentorial Pediatric Brain Tumors"],"prefix":"10.3390","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8024-8425","authenticated-orcid":false,"given":"Angelina","family":"Cistaro","sequence":"first","affiliation":[{"name":"Nuclear Medicine Department, Ospedali Galliera, 16128 Genova, Italy"},{"name":"AIMN Pediatric Study Group, 20159 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0810-6494","authenticated-orcid":false,"given":"Domenico","family":"Albano","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University of Brescia and Spedali Civili Brescia, 25123 Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8397-1640","authenticated-orcid":false,"given":"Pierpaolo","family":"Alongi","sequence":"additional","affiliation":[{"name":"Unit of Nuclear Medicine, Fondazione Istituto G. Giglio, 90015 Cefal\u00f9, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2842-0301","authenticated-orcid":false,"given":"Riccardo","family":"Laudicella","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Unit, Department of Biomedical and Dental Sciences and of Morpho-Functional Imaging, A.O.U. Policlinico G. Martino, University of Messina, 98125 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1176-9184","authenticated-orcid":false,"given":"Daniele Antonio","family":"Pizzuto","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital Z\u00fcrich, 8091 Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Formica","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Unit, Department of Biomedical and Dental Sciences and of Morpho-Functional Imaging, A.O.U. Policlinico G. Martino, University of Messina, 98125 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinzia","family":"Romagnolo","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Unit, Ospedali Riuniti, Torrette di Ancona, 60126 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Stracuzzi","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Unit, Department of Biomedical and Dental Sciences and of Morpho-Functional Imaging, A.O.U. Policlinico G. Martino, University of Messina, 98125 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3497-4236","authenticated-orcid":false,"given":"Viviana","family":"Frantellizzi","sequence":"additional","affiliation":[{"name":"Department of Radiological Sciences, Oncology and Anatomical Pathology, Sapienza University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6779-1471","authenticated-orcid":false,"given":"Arnoldo","family":"Piccardo","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Department, Ospedali Galliera, 16128 Genova, Italy"},{"name":"AIMN Pediatric Study Group, 20159 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9845-1384","authenticated-orcid":false,"given":"Natale","family":"Quartuccio","sequence":"additional","affiliation":[{"name":"AIMN Pediatric Study Group, 20159 Milan, Italy"},{"name":"Nuclear Medicine Unit, A.R.N.A.S. Ospedali Civico, Di Cristina e Benfratelli, 90127 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.1158\/1055-9965.EPI-14-0207","article-title":"Childhood brain tumor epidemiology: A brain tumor epidemiology consortium review","volume":"23","author":"Johnson","year":"2014","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s11060-008-9740-0","article-title":"Clinical epidemiology for childhood primary central nervous system tumors","volume":"92","author":"Bauchet","year":"2009","journal-title":"J. Neuro Oncol."},{"key":"ref_3","first-page":"e3079","article-title":"The Tentorium Cerebelli: A Comprehensive Review Including Its Anatomy, Embryology, and Surgical Techniques","volume":"10","author":"Rai","year":"2018","journal-title":"Cureus"},{"key":"ref_4","first-page":"158","article-title":"Presentaci\u00f3n cl\u00ednica de tumores intracraneales supratentoriales (ST) e infratentoriales (IT) en pacientes pedi\u00e1tricos","volume":"152","year":"2016","journal-title":"Gac. Med. Mex."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.3892\/ol.2015.2943","article-title":"Epidemiology of brain tumors in children aged two and under: A 10-year single-institute study","volume":"9","author":"Yu","year":"2015","journal-title":"Oncol Lett"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1177\/0883073808321768","article-title":"Initial management of childhood brain tumors: Neurosurgical considerations","volume":"23","author":"Nejat","year":"2008","journal-title":"J. Child Neurol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"40","DOI":"10.21037\/cco.2017.06.28","article-title":"Advanced magnetic resonance imaging in glioblastoma: A review","volume":"6","author":"Shukla","year":"2017","journal-title":"Chin. Clin. Oncol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1177\/0883073808320753","article-title":"Imaging of central nervous system tumors in children: Advances and limitations","volume":"23","year":"2008","journal-title":"J. Child Neurol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1007\/s00259-018-4207-9","article-title":"Joint EANM\/EANO\/RANO practice guidelines\/SNMMI procedure standards for imaging of gliomas using PET with radiolabelled amino acids and [(18)F]FDG: Version 1.0","volume":"46","author":"Law","year":"2019","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"S107","DOI":"10.1259\/bjr\/65711810","article-title":"Conventional MRI evaluation of gliomas","volume":"84 Spec No 2","author":"Upadhyay","year":"2011","journal-title":"Br. J. Radiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"194","DOI":"10.3348\/kjr.2017.18.1.194","article-title":"Advanced MRI for Pediatric Brain Tumors with Emphasis on Clinical Benefits","volume":"18","author":"Goo","year":"2017","journal-title":"Korean J. Radiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e305","DOI":"10.1016\/S1470-2045(20)30064-4","article-title":"Response assessment in paediatric low-grade glioma: Recommendations from the Response Assessment in Pediatric Neuro-Oncology (RAPNO) working group","volume":"21","author":"Fangusaro","year":"2020","journal-title":"Lancet Oncol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1002\/ijc.31937","article-title":"Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods","volume":"144","author":"Ferlay","year":"2019","journal-title":"Int. J. Cancer"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1093\/neuonc\/now058","article-title":"Response Assessment in Neuro-Oncology working group and European Association for Neuro-Oncology recommendations for the clinical use of PET imaging in gliomas","volume":"18","author":"Albert","year":"2016","journal-title":"Neuro Oncol."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Chiaravalloti, A., Filippi, L., Ricci, M., Cimini, A., and Schillaci, O. (2019). Molecular Imaging in Pediatric Brain Tumors. Cancers, 11.","DOI":"10.3390\/cancers11121853"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Quartuccio, N., Laudicella, R., Vento, A., Pignata, S., Mattoli, M.V., Filice, R., Comis, A.D., Arnone, A., Baldari, S., and Cabria, M. (2020). The Additional Value of (18)F-FDG PET and MRI in Patients with Glioma: A Review of the Literature from 2015 to 2020. Diagn. Basel Switz., 10.","DOI":"10.3390\/diagnostics10060357"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"728","DOI":"10.2967\/jnumed.109.070920","article-title":"Evaluation of focal cortical dysplasia and mixed neuronal and glial tumors in pediatric epilepsy patients using 18F-FDG and 11C-methionine pet","volume":"51","author":"Phi","year":"2010","journal-title":"J. Nucl. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1007\/s00259-010-1386-4","article-title":"Utility of positron emission tomography for tumour surveillance in children with neurofibromatosis type 1","volume":"37","author":"Moharir","year":"2010","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"486","DOI":"10.3171\/2010.1.PEDS09481","article-title":"Clinical impact of integrating positron emission tomography during surgery in 85 children with brain tumors","volume":"5","author":"Pirotte","year":"2010","journal-title":"J. Neurosurg. Pediatr."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"188","DOI":"10.2967\/jnumed.110.081463","article-title":"Evaluation of 18F-FDG PET and MRI associations in pediatric diffuse intrinsic brain stem glioma: A report from the Pediatric Brain Tumor Consortium","volume":"52","author":"Zukotynski","year":"2011","journal-title":"J. Nucl. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1159\/000366167","article-title":"Can multiparametric MRI and FDG-PET predict outcome in diffuse brainstem glioma? A report from a prospective phase-II study","volume":"49","author":"Goda","year":"2013","journal-title":"Pediatr. Neurosurg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.2967\/jnumed.112.115782","article-title":"Exploratory evaluation of MR permeability with 18F-FDG PET mapping in pediatric brain tumors: A report from the Pediatric Brain Tumor Consortium","volume":"54","author":"Zukotynski","year":"2013","journal-title":"J. Nucl. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1093\/neuonc\/nos321","article-title":"Evaluation of children with craniopharyngioma using carbon-11 methionine PET prior to proton therapy","volume":"15","author":"Laser","year":"2013","journal-title":"Neuro Oncol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.2967\/jnumed.114.139626","article-title":"18F-FDG PET and MR imaging associations across a spectrum of pediatric brain tumors: A report from the pediatric brain tumor consortium","volume":"55","author":"Zukotynski","year":"2014","journal-title":"J. Nucl. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"567","DOI":"10.3171\/2015.4.PEDS159","article-title":"Postoperative cerebral glucose metabolism in pediatric patients receiving proton therapy for craniopharyngioma","volume":"16","author":"Hua","year":"2015","journal-title":"J. Neurosurg. Pediatr."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.2967\/jnumed.116.185389","article-title":"Correlation of (18)F-FDG PET and MRI Apparent Diffusion Coefficient Histogram Metrics with Survival in Diffuse Intrinsic Pontine Glioma: A Report from the Pediatric Brain Tumor Consortium","volume":"58","author":"Zukotynski","year":"2017","journal-title":"J. Nucl. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1536012116687651","DOI":"10.1177\/1536012116687651","article-title":"Multimodal Imaging of Patients With Gliomas Confirms (11)C-MET PET as a Complementary Marker to MRI for Noninvasive Tumor Grading and Intraindividual Follow-Up After Therapy","volume":"16","author":"Laukamp","year":"2017","journal-title":"Mol. Imaging"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1093\/neuonc\/nou022","article-title":"Accuracy of distinguishing between dysembryoplastic neuroepithelial tumors and other epileptogenic brain neoplasms with [11C]methionine PET","volume":"16","author":"Rheims","year":"2014","journal-title":"Neuro Oncol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"88","DOI":"10.2967\/jnumed.114.148734","article-title":"The usefulness of dynamic O-(2-18F-fluoroethyl)-L-tyrosine PET in the clinical evaluation of brain tumors in children and adolescents","volume":"56","author":"Dunkl","year":"2015","journal-title":"J. Nucl. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s00381-014-2552-y","article-title":"(18)F-FET-PET guided surgical biopsy and resection in children and adolescence with brain tumors","volume":"31","author":"Misch","year":"2015","journal-title":"Child\u2019s Nerv. Syst."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"718","DOI":"10.2967\/jnumed.113.125500","article-title":"Value of 18F-3,4-dihydroxyphenylalanine PET\/MR image fusion in pediatric supratentorial infiltrative astrocytomas: A prospective pilot study","volume":"55","author":"Morana","year":"2014","journal-title":"J. Nucl. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1007\/s00259-016-3333-5","article-title":"Ability of (18)F-DOPA PET\/CT and fused (18)F-DOPA PET\/MRI to assess striatal involvement in paediatric glioma","volume":"43","author":"Morana","year":"2016","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1007\/s00259-017-3777-2","article-title":"Grading and outcome prediction of pediatric diffuse astrocytic tumors with diffusion and arterial spin labeling perfusion MRI in comparison with 18F-DOPA PET","volume":"44","author":"Morana","year":"2017","journal-title":"Eur. J. Nucl. Med. Mol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1093\/neuonc\/nov099","article-title":"Diagnostic and prognostic value of 18F-DOPA PET and 1H-MR spectroscopy in pediatric supratentorial infiltrative gliomas: A comparative study","volume":"17","author":"Morana","year":"2015","journal-title":"Neuro Oncol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s40336-016-0213-8","article-title":"Clinical PET\/MRI in neurooncology: Opportunities and challenges from a single-institution perspective","volume":"5","author":"Marner","year":"2017","journal-title":"Clin. Transl. Imaging"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1097\/MPH.0b013e31820ad915","article-title":"Use of positron emission tomography in the evaluation of diffuse intrinsic brainstem gliomas in children","volume":"33","author":"Rosenfeld","year":"2011","journal-title":"J. Pediatr. Hematol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1007\/s00066-013-0408-0","article-title":"Incidence and clinical course of radionecrosis in children with brain tumors. A 20-year longitudinal observational study","volume":"189","author":"Strenger","year":"2013","journal-title":"Strahlenther. Onkol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.prro.2017.07.011","article-title":"Prostate cancer-specific PET radiotracers: A review on the clinical utility in recurrent disease","volume":"8","author":"Evans","year":"2018","journal-title":"Pr. Radiat. Oncol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e40","DOI":"10.1097\/RLU.0000000000000556","article-title":"18F-fluoroethylcholine (18F-Cho) PET\/MRI functional parameters in pediatric astrocytic brain tumors","volume":"40","author":"Fraioli","year":"2015","journal-title":"Clin. Nucl. Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1002\/pbc.25538","article-title":"Evaluation of treatment response using integrated 18F-labeled choline positron emission tomography\/magnetic resonance imaging in adolescents with intracranial non-germinomatous germ cell tumours","volume":"62","author":"Tsouana","year":"2015","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_41","first-page":"28","article-title":"(18)F-FDOPA PET\/MRI for monitoring early response to bevacizumab in children with recurrent brain tumors","volume":"5","author":"Gauvain","year":"2018","journal-title":"Neurooncol. Pract."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1007\/s00259-019-04392-7","article-title":"(68)Ga-NOTA-Aca-BBN(7-14) PET imaging of GRPR in children with optic pathway glioma","volume":"46","author":"Zhang","year":"2019","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"711","DOI":"10.2967\/jnumed.116.180216","article-title":"Molecular Drug Imaging: (89)Zr-Bevacizumab PET in Children with Diffuse Intrinsic Pontine Glioma","volume":"58","author":"Jansen","year":"2017","journal-title":"J. Nucl. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1016\/S0959-8049(02)00413-6","article-title":"PET for in vivo pharmacokinetic and pharmacodynamic measurements","volume":"38","author":"Gupta","year":"2002","journal-title":"Eur. J. Cancer"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"47","DOI":"10.14791\/btrt.2018.6.e13","article-title":"Current Radiopharmaceuticals for Positron Emission Tomography of Brain Tumors","volume":"6","author":"Jung","year":"2018","journal-title":"Brain Tumor Res. Treat."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1007\/s00381-016-3125-z","article-title":"PET and SPECT studies in children with hemispheric low-grade gliomas","volume":"32","year":"2016","journal-title":"Child\u2019s Nerv. 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