{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:26:01Z","timestamp":1772252761370,"version":"3.50.1"},"reference-count":15,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T00:00:00Z","timestamp":1627948800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>(1) Background. Stevens\u2013Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe mucocutaneous reactions, characterized by extensive necrosis and detachment of the epidermis. (2) Case presentation. We present a case of a 46-year-old patient with late-stage high-grade serous ovarian cancer who was primarily treated with neoadjuvant chemotherapy and interval debulking, which was followed by adjuvant chemotherapy. At first recurrence, she was again treated with chemotherapy, and due to severe abdominal pain, an elastomeric pump containing analgesics, anti-inflammatories, and ondansetron was administered. In the same month, she was admitted to the hospital due to severe dysphagia, and in the following days she developed haemorrhagic vesiculobullous lesions on the facial skin and trunk. Stevens\u2013Johnson syndrome was confirmed and ondansetron as a plausible leading cause was discontinued. Despite multimodal treatment, her condition deteriorated, and she died. (3) Discussion and conclusion. Although gynaecologists rarely encounter Stevens\u2013Johnson syndrome, high mortality of the disease should ensure a low threshold for diagnosing and treating this disease.<\/jats:p>","DOI":"10.3390\/curroncol28040256","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T08:16:39Z","timestamp":1627978599000},"page":"2928-2932","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Case of Stevens\u2013Johnson Syndrome in Recurrent Late-Stage Ovarian Cancer Patient after Management of Chronic Pain with Elastomeric Pump"],"prefix":"10.3390","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5134-4466","authenticated-orcid":false,"given":"Andrej","family":"Cokan","sequence":"first","affiliation":[{"name":"Department for Gynaecological and Breast Oncology, University Medical Centre Maribor, Ljubljanska ulica 5, 2000 Maribor, Slovenia"},{"name":"Medical Faculty, University of Maribor, Taborska ulica 8, 2000 Maribor, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vida Gavri\u0107","family":"Gavri\u0107 Lovrec","sequence":"additional","affiliation":[{"name":"Medical Faculty, University of Maribor, Taborska ulica 8, 2000 Maribor, Slovenia"},{"name":"Department for Reproductive Medicine and Gynaecological Endocrinology, University Medical Centre Maribor, Ljubljanska ulica 5, 2000 Maribor, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iztok","family":"Taka\u010d","sequence":"additional","affiliation":[{"name":"Medical Faculty, University of Maribor, Taborska ulica 8, 2000 Maribor, Slovenia"},{"name":"Clinic for Gynaecology and Perinatology, University Medical Centre Maribor, Ljubljanska ulica 5, 2000 Maribor, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/j.jid.2017.01.003","article-title":"Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: Associations, Outcomes, and Pathobiology\u2014Thirty Years of Progress but Still Much to Be Done","volume":"137","author":"Stern","year":"2017","journal-title":"J. Investig. Dermatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"503","DOI":"10.4103\/0019-5154.103082","article-title":"Inadvertent provocative oral ondansetron use leading to toxic epidermal necrolysis in an HIV-infected patient","volume":"57","author":"Nayak","year":"2012","journal-title":"Indian J. Dermatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1038\/jid.2012.510","article-title":"Comprehensive Survival Analysis of a Cohort of Patients with Stevens\u2013Johnson Syndrome and Toxic Epidermal Necrolysis","volume":"133","author":"Sekula","year":"2013","journal-title":"J. Investig. Dermatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.currproblcancer.2016.12.001","article-title":"Cutaneous adverse effects of the immune checkpoint inhibitors","volume":"41","author":"Collins","year":"2017","journal-title":"Curr. Probl. Cancer"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1097\/INF.0000000000001571","article-title":"Fever in Stevens\u2013Johnson Syndrome and Toxic Epidermal Necrolysis in Pediatric Cases: Laboratory Work-up and Antibiotic Therapy","volume":"36","author":"Paulmann","year":"2017","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1111\/bjd.14530","article-title":"U.K. guidelines for the management of Stevens\u2013Johnson syndrome\/toxic epidermal necrolysis in adults 2016","volume":"174","author":"Creamer","year":"2016","journal-title":"Br. J. Dermatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1097\/ICO.0b013e31802eb264","article-title":"Erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis: Acute ocular manifestations, causes, and management","volume":"26","author":"Chang","year":"2007","journal-title":"Cornea"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1111\/j.1365-2133.2012.10965.x","article-title":"The efficacy of intravenous immunoglobulin for the treatment of toxic epidermal necrolysis: A systematic review and meta-analysis","volume":"167","author":"Huang","year":"2012","journal-title":"Br. J. Dermatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"135","DOI":"10.2147\/JIR.S160964","article-title":"A meta-analysis of cyclosporine treatment for Stevens\u2013Johnson syndrome\/toxic epidermal necrolysis","volume":"11","author":"Ng","year":"2018","journal-title":"J. Inflamm. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1172\/JCI93349","article-title":"Randomized, controlled trial of TNF-\u03b1 antagonist in CTL-mediated severe cutaneous adverse reactions","volume":"128","author":"Wang","year":"2018","journal-title":"J. Clin. Investig."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1586\/eci.11.66","article-title":"The current understanding of Stevens\u2013Johnson syndrome and toxic epidermal necrolysis","volume":"7","author":"Mockenhaupt","year":"2011","journal-title":"Expert Rev. Clin. Immunol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"4","DOI":"10.5070\/D3234034628","article-title":"The effect of comorbidities on overall mortality in Stevens- Johnson Syndrome: An analysis of the Nationwide Inpatient Sample","volume":"23","author":"Ezaldein","year":"2017","journal-title":"Dermatol. Online J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1111\/jdv.16137","article-title":"Accuracy of SCORTEN to predict the prognosis of Stevens-Johnson syndrome\/toxic epidermal necrolysis: A systematic review and meta-analysis","volume":"34","year":"2020","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1177\/030089168607200316","article-title":"Stevens-Johnson Syndrome and Fatal Pulmonary Toxicity to Combination Chemotherapy Containing Bleomycin: A Case Report","volume":"72","author":"Giaccone","year":"1986","journal-title":"Tumori J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1016\/j.jid.2017.05.010","article-title":"Incidence and Triggers of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in a Large Cancer Patient Cohort","volume":"137","author":"Gillis","year":"2017","journal-title":"J. Investig. Dermatol."}],"container-title":["Current Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1718-7729\/28\/4\/256\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:39:42Z","timestamp":1760164782000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1718-7729\/28\/4\/256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,3]]},"references-count":15,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,8]]}},"alternative-id":["curroncol28040256"],"URL":"https:\/\/doi.org\/10.3390\/curroncol28040256","relation":{"has-preprint":[{"id-type":"doi","id":"10.20944\/preprints202107.0052.v1","asserted-by":"object"}]},"ISSN":["1718-7729"],"issn-type":[{"value":"1718-7729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,3]]}}}