{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T21:14:48Z","timestamp":1768079688782,"version":"3.49.0"},"reference-count":23,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T00:00:00Z","timestamp":1630368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Background: This study aimed to validate the Brazilian version of EORTC CAT Core and compare the Brazilian results with those from the original European EORTC CAT Core validation study. Methods: After validated translation, 168 cancer patients from Brazil receiving radiation therapy with or without chemotherapy was assessed. Translated EORTC CAT Core and all QLQ-C30 items were administered to patients using CHES (Computer-Based Health Evaluation System) before (T0) and after (T1) treatment initiation. The association between QLQ-C30 and CAT scores and ceiling\/floor effects were estimated. Based on estimates of relative validity (cross-sectional, known-group differences and changes over time), relative sample-size requirements for CAT compared to QLQ-C30 were estimated. Results: Correlation coefficients between CAT and QLQ-C30 domains ranged from 0.63 to 0.93; except for dyspnoea, all coefficients were &gt;0.82 (corresponding figures were 0.81\u20130.93 in the European study). On average across domains, floor\/ceiling was reduced by 10% using CAT (9% in the European study) corresponding to a relative reduction of 32% (37% in the European study). Analyses of known-group validity and responsiveness indicated that, on average across domains, the sample-size requirements may be reduced by 17% using CAT rather than QLQ-C30, without loss of power (28% in the European study). The Brazilian sample had less symptom\/quality of life impairment than the European sample, which likely explains the lower sample-size reduction using CAT when comparing with the European sample. Conclusions: The results in the Brazilian cohort were generally similar to those from the European sample and confirm the validity and usefulness of the EORTC CAT Core.<\/jats:p>","DOI":"10.3390\/curroncol28050291","type":"journal-article","created":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T08:42:32Z","timestamp":1630399352000},"page":"3373-3383","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Brazilian Validation of the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group (QLG) Computerised Adaptive Tests (CAT) Core"],"prefix":"10.3390","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3298-3684","authenticated-orcid":false,"given":"Gustavo Nader","family":"Marta","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Hospital S\u00edrio-Liban\u00eas, Rua Dona Adma Jajet 115, Sao Paulo 01308-050, Brazil"},{"name":"Latin America Cooperative Oncology Group (LACOG), Porto Alegre 90619-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom\u00e1s Y. T.","family":"de Souza","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Hospital S\u00edrio-Liban\u00eas, Rua Dona Adma Jajet 115, Sao Paulo 01308-050, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3252-3511","authenticated-orcid":false,"given":"Alice R. N. de Souza e","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Hospital S\u00edrio-Liban\u00eas, Rua Dona Adma Jajet 115, Sao Paulo 01308-050, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Paula A.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Hospital S\u00edrio-Liban\u00eas, Rua Dona Adma Jajet 115, Sao Paulo 01308-050, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David R.","family":"Ferreira Neto","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Hospital S\u00edrio-Liban\u00eas, Rua Dona Adma Jajet 115, Sao Paulo 01308-050, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2361-8439","authenticated-orcid":false,"given":"Rie N.","family":"Asso","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Hospital S\u00edrio-Liban\u00eas, Rua Dona Adma Jajet 115, Sao Paulo 01308-050, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6311-5791","authenticated-orcid":false,"given":"Fabiana A. M.","family":"Degrande","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Hospital S\u00edrio-Liban\u00eas, Rua Dona Adma Jajet 115, Sao Paulo 01308-050, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guilherme","family":"Nader-Marta","sequence":"additional","affiliation":[{"name":"Academic Trials Promoting Team, Institut Jules Bordet, l\u2019Universit\u00e9 Libre de Bruxelles (U.L.B), 1210 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maur\u00edcio F.","family":"da Silva","sequence":"additional","affiliation":[{"name":"Latin America Cooperative Oncology Group (LACOG), Porto Alegre 90619-900, Brazil"},{"name":"Radiation Oncology Unit, Santa Maria University Hospital (UFSM), Santa Maria 97105-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Gadia","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Hospital S\u00edrio-Liban\u00eas, Rua Dona Adma Jajet 115, Sao Paulo 01308-050, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samir A.","family":"Hanna","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Hospital S\u00edrio-Liban\u00eas, Rua Dona Adma Jajet 115, Sao Paulo 01308-050, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Holzner","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Psychiatry II, A-6020 Innsbruck, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Everardo D.","family":"Saad","sequence":"additional","affiliation":[{"name":"Dendrix Research, Sao Paulo 04534-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morten Aagaard","family":"Petersen","sequence":"additional","affiliation":[{"name":"Palliative Care Research Unit, Department of Geriatrics and Palliative Medicine GP, Bispebjerg & Frederiksberg Hospital, University of Copenhagen, 2400 Copenhagen NV, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/jnci\/85.5.365","article-title":"The European Organization for Research and Treatment of Cancer QLQ-C30: A Quality-of-Life Instrument for Use in International Clinical Trials in Oncology","volume":"85","author":"Aaronson","year":"1993","journal-title":"J. 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