{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T11:50:22Z","timestamp":1771501822734,"version":"3.50.1"},"reference-count":29,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,9,26]],"date-time":"2021-09-26T00:00:00Z","timestamp":1632614400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Radical treatment of localized prostate cancer in elderly patients may lead to unacceptable treatment-associated toxicities that adversely impact quality of life without improving survival outcomes. This study reports on a cohort of 54 elderly (&gt;70 years) patients that received 4000\u20135000 cGy of palliative external beam radiotherapy (EBRT) as an alternative to androgen deprivation therapy (ADT). The primary outcome of interest was the period of ADT-free survival, and secondary outcomes included overall survival (OS) and metastases-free survival (MFS). Kaplan\u2013Meier regression was used to estimate survival outcomes. Thirty-six (67%) patients achieved a break in ADT post-radiotherapy, with a median time to ADT reinitiation of 20 months. Common Terminology Criteria for Adverse Events (CTCAE) were limited to low-grade gastrointestinal (GI) or genitourinary (GU) toxicities, with no skin toxicities observed. Grade 1 GI toxicity was observed in 9 (17%) patients, and grades 1 and 2 GU toxicities were observed in 13 (24%) and 3 (6%) patients, respectively, with no higher-grade toxicities reported. Five-year MFS and OS were 56% and 78%, respectively. In summary, the treatment regimen was well-tolerated and achieved durable ADT-free survival in most patients. Dose-reduced EBRT appears to be a viable alternative to ADT in elderly patients with localized prostate cancer.<\/jats:p>","DOI":"10.3390\/curroncol28050318","type":"journal-article","created":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T01:59:47Z","timestamp":1632707987000},"page":"3729-3737","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical Outcomes from Dose-Reduced Radiotherapy to the Prostate in Elderly Patients with Localized Prostate Cancer"],"prefix":"10.3390","volume":"28","author":[{"given":"Nina","family":"Samson","sequence":"first","affiliation":[{"name":"Department of Oncology, University of Calgary, Calgary, AB T2N 4N2, Canada"},{"name":"Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4269-7622","authenticated-orcid":false,"given":"Rutvij A.","family":"Khanolkar","sequence":"additional","affiliation":[{"name":"Department of Oncology, University of Calgary, Calgary, AB T2N 4N2, Canada"},{"name":"Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Quirk","sequence":"additional","affiliation":[{"name":"Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada"},{"name":"Department of Physics and Astronomy, University of Calgary, Calgary, AB T2N 1N4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harvey","family":"Quon","sequence":"additional","affiliation":[{"name":"Department of Oncology, University of Calgary, Calgary, AB T2N 4N2, Canada"},{"name":"Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Roumeliotis","sequence":"additional","affiliation":[{"name":"Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada"},{"name":"Department of Physics and Astronomy, University of Calgary, Calgary, AB T2N 1N4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Balogh","sequence":"additional","affiliation":[{"name":"Department of Oncology, University of Calgary, Calgary, AB T2N 4N2, Canada"},{"name":"Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Sia","sequence":"additional","affiliation":[{"name":"Department of Oncology, University of Calgary, Calgary, AB T2N 4N2, Canada"},{"name":"Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kundan","family":"Thind","sequence":"additional","affiliation":[{"name":"Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada"},{"name":"Department of Physics and Astronomy, University of Calgary, Calgary, AB T2N 1N4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siraj","family":"Husain","sequence":"additional","affiliation":[{"name":"Department of Oncology, University of Calgary, Calgary, AB T2N 4N2, Canada"},{"name":"Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Martell","sequence":"additional","affiliation":[{"name":"Department of Oncology, University of Calgary, Calgary, AB T2N 4N2, Canada"},{"name":"Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21654","article-title":"Cancer Statistics, 2021","volume":"71","author":"Siegel","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1111\/j.1464-410X.2011.10197.x","article-title":"Dramatic Increase in Prostate Cancer Cases by 2021","volume":"108","author":"Quon","year":"2011","journal-title":"BJU Int."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"E199","DOI":"10.1503\/cmaj.191292","article-title":"Projected Estimates of Cancer in Canada in 2020","volume":"192","author":"Brenner","year":"2020","journal-title":"Can. Med. Assoc. J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.1001\/jama.2017.7248","article-title":"The Diagnosis and Treatment of Prostate Cancer","volume":"317","author":"Litwin","year":"2017","journal-title":"JAMA"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1001\/jama.280.11.969","article-title":"Biochemical Outcome After Radical Prostatectomy, External Beam Radiation Therapy, or Interstitial Radiation Therapy for Clinically Localized Prostate Cancer","volume":"280","author":"Whittington","year":"1998","journal-title":"JAMA"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3322\/caac.21388","article-title":"The Eighth Edition AJCC Cancer Staging Manual: Continuing to Build a Bridge from a Population-Based to a More \u201cPersonalized\u201d Approach to Cancer Staging","volume":"67","author":"Amin","year":"2017","journal-title":"CA Cancer J. Clin."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1007\/s003459900102","article-title":"Management of Locally Advanced Prostate Cancer","volume":"18","year":"2000","journal-title":"World J. Urol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.urology.2007.08.055","article-title":"Contemporary Evaluation of the D\u2019Amico Risk Classification of Prostate Cancer","volume":"70","author":"Hernandez","year":"2007","journal-title":"Urology"},{"key":"ref_9","first-page":"1151","article-title":"Management of Locally Advanced Prostate Cancer","volume":"68","author":"Ichikawa","year":"2010","journal-title":"Nihon rinsho. Jpn. J. Clin. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"13880","DOI":"10.1038\/s41598-017-13119-3","article-title":"Definitive Radiotherapy for Older Patients with Prostate Cancer: Experience of a Medical Center in Taiwan","volume":"7","author":"Wu","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1056\/NEJMoa1606220","article-title":"10-Year Outcomes after Monitoring, Surgery, or Radiotherapy for Localized Prostate Cancer","volume":"375","author":"Hamdy","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3747\/co.v17i0.709","article-title":"Androgen Deprivation Therapy for Prostate Cancer-Review of Indications in 2010","volume":"17","author":"Quon","year":"2010","journal-title":"Curr. Oncol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.eururo.2014.07.010","article-title":"Adverse Effects of Androgen Deprivation Therapy and Strategies to Mitigate Them","volume":"67","author":"Nguyen","year":"2015","journal-title":"Eur. Urol."},{"key":"ref_14","first-page":"1291","article-title":"Long-Term Follow-up of a Randomized Trial of Radiation With or Without Androgen Deprivation Therapy for Localized Prostate Cancer","volume":"314","author":"Chen","year":"2016","journal-title":"JAMA"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.ijrobp.2007.06.050","article-title":"Long-Term Treatment Sequelae After External Beam Irradiation With or Without Hormonal Manipulation for Adenocarcinoma of the Prostate: Analysis of Radiation Therapy Oncology Group Studies 85-31, 86-10, and 92-02","volume":"70","author":"Lawton","year":"2008","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1200\/JCO.2016.71.7397","article-title":"Randomized Trial of a Hypofractionated Radiation Regimen for the Treatment of Localized Prostate Cancer","volume":"35","author":"Catton","year":"2017","journal-title":"J. Clin. Oncol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/S1470-2045(16)30102-4","article-title":"Conventional versus Hypofractionated High-Dose Intensity-Modulated Radiotherapy for Prostate Cancer: 5-Year Outcomes of the Randomised, Non-Inferiority, Phase 3 CHHiP Trial","volume":"17","author":"Dearnaley","year":"2016","journal-title":"Lancet Oncol."},{"key":"ref_18","unstructured":"National Cancer Institute (2017). Common Terminology Criteria for Adverse Events (CTCAE).v.5.0, Cancer Therapy Evaluation Program."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1093\/jnci\/djn255","article-title":"Radical Prostatectomy versus Watchful Waiting in Localized Prostate Cancer: The Scandinavian Prostate Cancer Group-4 Randomized Trial","volume":"100","author":"Holmberg","year":"2008","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1111\/j.1464-410X.2010.09652.x","article-title":"Watchful Waiting for Localized Prostate Cancer in the PSA Era: What Have Been the Triggers for Intervention?","volume":"107","author":"Coen","year":"2011","journal-title":"BJU Int."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1056\/NEJMoa1615869","article-title":"Follow-up of Prostatectomy versus Observation for Early Prostate Cancer","volume":"377","author":"Wilt","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.eururo.2013.02.025","article-title":"Long-Term Distress after Radical Prostatectomy versus Watchful Waiting in Prostate Cancer: A Longitudinal Study from the Scandinavian Prostate Cancer Group-4 Randomized Clinical Trial","volume":"64","author":"Garmo","year":"2013","journal-title":"Eur. Urol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3452","DOI":"10.1200\/JCO.2008.20.0923","article-title":"Impact of Androgen Deprivation Therapy on Cardiovascular Disease and Diabetes","volume":"27","author":"Alibhai","year":"2009","journal-title":"J. Clin. Oncol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.eururo.2013.10.032","article-title":"Cardiovascular Morbidity Associated with Gonadotropin Releasing Hormone Agonists and an Antagonist","volume":"65","author":"Albertsen","year":"2014","journal-title":"Eur. Urol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1002\/cncr.24283","article-title":"Review of Major Adverse Effects of Androgen-Deprivation Therapy in Men with Prostate Cancer","volume":"115","author":"Taylor","year":"2009","journal-title":"Cancer"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1056\/NEJMoa2004325","article-title":"Oral Relugolix for Androgen-Deprivation Therapy in Advanced Prostate Cancer","volume":"382","author":"Shore","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1016\/j.juro.2010.08.012","article-title":"Cardiovascular Safety of Degarelix: Results from a 12-Month, Comparative, Randomized, Open Label, Parallel Group Phase III Trial in Patients with Prostate Cancer","volume":"184","author":"Smith","year":"2010","journal-title":"J. Urol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/aja.2011.104","article-title":"Muscle Function, Physical Performance and Body Composition Changes in Men with Prostate Cancer Undergoing Androgen Deprivation Therapy","volume":"14","author":"Storer","year":"2012","journal-title":"Asian J. Androl."},{"key":"ref_29","first-page":"217","article-title":"Sarcopenia and Androgens: A Link between Pathology and Treatment","volume":"5","author":"Varela","year":"2014","journal-title":"Front. Endocrinol."}],"container-title":["Current Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1718-7729\/28\/5\/318\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:05:23Z","timestamp":1760166323000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1718-7729\/28\/5\/318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,26]]},"references-count":29,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,10]]}},"alternative-id":["curroncol28050318"],"URL":"https:\/\/doi.org\/10.3390\/curroncol28050318","relation":{},"ISSN":["1718-7729"],"issn-type":[{"value":"1718-7729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,26]]}}}