{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:31:42Z","timestamp":1760236302177,"version":"build-2065373602"},"reference-count":63,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T00:00:00Z","timestamp":1637193600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Primary splenic lymphoma (PSL) is a rare malignancy representing about 1% of all lymphoproliferative disorders, when using a strict definition that allows only involvement of spleen and hilar lymph nodes. In contrast, secondary low-grade B-cell lymphomas in the spleen, such as follicular lymphomas (FL), lymphoplasmacytic lymphoma and chronic lymphocytic leukemia\/ small lymphocytic lymphoma, particularly as part of advanced stage disease, are more common. Indolent B cell lymphomas expressing CD10 almost always represent FL, which in its primary splenic form is the focus of this review. Primary splenic follicular lymphoma (PSFL) is exceedingly infrequent. This type of lymphoproliferative disorder is understudied and, in most cases, clinically characterized by splenomegaly or cytopenias related to hypersplenism. The diagnosis requires correlation of histopathology of spleen, blood and\/or bone marrow with the correct immunophenotype (determined by flow cytometry and\/or immunohistochemistry) and if necessary, additional molecular profiling. Management of this incurable disease is evolving, and splenectomy remains the mainstream treatment for stage I PSFL.<\/jats:p>","DOI":"10.3390\/curroncol28060407","type":"journal-article","created":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T08:53:56Z","timestamp":1637225636000},"page":"4821-4831","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Low-Grade Primary Splenic CD10-Positive Small B-Cell Lymphoma\/Follicular Lymphoma"],"prefix":"10.3390","volume":"28","author":[{"given":"Rami","family":"Abdulbaki","sequence":"first","affiliation":[{"name":"Department of Pathology, George Washington University, Washington, DC 20037, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parastou","family":"Tizro","sequence":"additional","affiliation":[{"name":"City of Hope Medical Canter, Department of Pathology, Duarte, CA 91010, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor E.","family":"Nava","sequence":"additional","affiliation":[{"name":"Department of Pathology, George Washington University, Washington, DC 20037, USA"},{"name":"Veterans Affairs Medical Center, Washington, DC 20052, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6993-2450","authenticated-orcid":false,"given":"Maria","family":"Gomes da Silva","sequence":"additional","affiliation":[{"name":"Department of Hematology, Initituto Portugu\u00eas de Oncologia, 1649-028 Lisboa, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o L.","family":"Ascens\u00e3o","sequence":"additional","affiliation":[{"name":"Veterans Affairs Medical Center, Department of Hematology, Washington, DC 20052, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/stem.592","article-title":"Concise review: Neutral endopeptidase (CD10): A multifaceted environment actor in stem cells, physiological mechanisms, and cancer","volume":"29","year":"2011","journal-title":"Stem Cells"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1096\/fasebj.3.2.2521610","article-title":"Neutral endopeptidase 24.11 (enkephalinase) and related regulators of peptide hormones","volume":"3","author":"Skidgel","year":"1989","journal-title":"FASEB J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0002-9440(10)65253-4","article-title":"NCL-CD10-270: A new monoclonal antibody recognizing CD10 in paraffin-embedded tissue","volume":"154","author":"McIntosh","year":"1999","journal-title":"Am. 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