{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T11:35:30Z","timestamp":1785152130970,"version":"3.55.0"},"reference-count":30,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,1,2]],"date-time":"2022-01-02T00:00:00Z","timestamp":1641081600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007052","name":"University of Verona","doi-asserted-by":"publisher","award":["FUR 2020 to VB"],"award-info":[{"award-number":["FUR 2020 to VB"]}],"id":[{"id":"10.13039\/501100007052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008908","name":"University of Messina","doi-asserted-by":"publisher","award":["Research and Mobility 2018, to MC and VB"],"award-info":[{"award-number":["Research and Mobility 2018, to MC and VB"]}],"id":[{"id":"10.13039\/501100008908","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Intraventricular meningiomas (IVMs) are rare (0.5\u20135%) and usually low-grade (90% grade I) brain neoplasms. Their recurrence rate is lower than that of extra-axial meningiomas, but their surgical resection can be burdened with life-threatening complications, which represent the major cause of the reported 4% mortality. The aim of this study is to characterize the molecular portrait of IVMs to identify potential therapeutic targets. For this, we explored mutations and copy number variations (CNV) of 409 cancer-related genes and tumor mutational burden (TMB) of six cases, using next-generation sequencing. Five IVMs were grade I and one was grade II; none recurred, in spite of partial surgical resection in one case. NF2 mutation was the only recurring alteration and was present in three of the six IVMs, in association with SMARCB1 mutation in one case. None of the cases was hypermutated (TMB &gt; 10 mutations\/Mb). NF2-mutant progressing or recurring IVMs could potentially be treated with targeted therapies applied to other NF2-mutant tumors, as an alternative to surgery or radiosurgery, while in view of their low TMB they are unlikely candidates to immune check-point inhibition.<\/jats:p>","DOI":"10.3390\/curroncol29010017","type":"journal-article","created":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T22:51:50Z","timestamp":1641250310000},"page":"178-185","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Intraventricular Meningiomas: Clinical-Pathological and Genetic Features of a Monocentric Series"],"prefix":"10.3390","volume":"29","author":[{"given":"Serena","family":"Ammendola","sequence":"first","affiliation":[{"name":"Dipartimento di Diagnostica e Sanit\u00e0 Pubblica, Universit\u00e0 degli studi di Verona, 371234 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0866-4499","authenticated-orcid":false,"given":"Michele","family":"Simbolo","sequence":"additional","affiliation":[{"name":"Dipartimento di Diagnostica e Sanit\u00e0 Pubblica, Universit\u00e0 degli studi di Verona, 371234 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Ciaparrone","sequence":"additional","affiliation":[{"name":"Dipartimento di Diagnostica e Sanit\u00e0 Pubblica, Universit\u00e0 degli studi di Verona, 371234 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola Chiara","family":"Rizzo","sequence":"additional","affiliation":[{"name":"Dipartimento di Diagnostica e Sanit\u00e0 Pubblica, Universit\u00e0 degli studi di Verona, 371234 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3240-0506","authenticated-orcid":false,"given":"Maria","family":"Caffo","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Section of Neurosurgery, University of Messina, 98122 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giampietro","family":"Pinna","sequence":"additional","affiliation":[{"name":"Unit of Neurosurgery, Department of Neurosciences, Hospital Trust of Verona, 37126 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Sala","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Biomedicines and Movement Sciences, Institute of Neurosurgery, University of Verona, 37126 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1678-739X","authenticated-orcid":false,"given":"Aldo","family":"Scarpa","sequence":"additional","affiliation":[{"name":"Dipartimento di Diagnostica e Sanit\u00e0 Pubblica, Universit\u00e0 degli studi di Verona, 371234 Verona, Italy"},{"name":"ARC-Net Research Centre, University and Hospital Trust of Verona, 37134 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7086-1920","authenticated-orcid":false,"given":"Valeria","family":"Barresi","sequence":"additional","affiliation":[{"name":"Dipartimento di Diagnostica e Sanit\u00e0 Pubblica, Universit\u00e0 degli studi di Verona, 371234 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,2]]},"reference":[{"key":"ref_1","unstructured":"Louis, D.N., Ohgaki, H., Wisteler, O.D., Cavenee, W.K., Ellison, D.W., Figarella-Branger, D., Perry, A., Refeinberger, G., and von Deimling, A. 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