{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:18:56Z","timestamp":1790731136606,"version":"4.1.0"},"reference-count":30,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,1,21]],"date-time":"2022-01-21T00:00:00Z","timestamp":1642723200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Objective: Given the increasing risk of young-onset colorectal cancer (yCRC) among adults under 50 years, it is important to understand impacts on reproductive health. Our objective was to assess experiences with reproductive health after yCRC diagnosis among females. Methods: We conducted a cross-sectional study among females, 18 years or older, who have been diagnosed yCRC and are able to communicate in English. Data were gathered using an online survey involving both quantitative (e.g., multiple choice) and qualitative (e.g., open-ended text) questions on pregnancy history, influence of yCRC on reproductive decisions, and experiences with reproductive healthcare. Results: Altogether, 101 females with yCRC participated, including 23 who had never been pregnant and 78 who had been pregnant. yCRC influenced family planning goals for one-third of participants. Furthermore, compared to participants who completed treatment, those currently undergoing treatment had higher odds of indicating their yCRC diagnosis influenced family planning goals (adjusted odds ratio 4.93; 95% confidence interval 1.29 to 18.78). Although 53 (52.5%) participants indicated having discussions regarding reproductive health with healthcare provider(s), 44 (43.6%) did not. Content analysis of open-ended survey questions identified themes on the emotional impacts, experiences with reproductive healthcare, reproductive and family planning considerations, and the related issue of sexual health impacts of yCRC. Conclusions: Gaps in care, related to limited reproductive health discussions, influence of yCRC on family planning, and experiencing lasting reproductive health impacts highlight the need for improving reproductive healthcare, particularly for females diagnosed with yCRC.<\/jats:p>","DOI":"10.3390\/curroncol29020042","type":"journal-article","created":{"date-parts":[[2022,1,21]],"date-time":"2022-01-21T08:37:18Z","timestamp":1642754238000},"page":"465-478","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Reproductive Health Experiences of Females Diagnosed with Young-Onset Colorectal Cancer: A Multi-Method Cross-Sectional Survey"],"prefix":"10.3390","volume":"29","author":[{"given":"Louise","family":"Araujo","sequence":"first","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, University of British Columbia, 2405 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada"},{"name":"Collaboration for Outcomes Research and Evaluation, Vancouver, BC V6T 1Z3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nevena","family":"Rebic","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, University of British Columbia, 2405 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada"},{"name":"Collaboration for Outcomes Research and Evaluation, Vancouver, BC V6T 1Z3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hallie","family":"Dau","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, University of British Columbia, 2405 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada"},{"name":"Collaboration for Outcomes Research and Evaluation, Vancouver, BC V6T 1Z3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori","family":"Brotto","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Faculty of Medicine, University of British Columbia, Vancouver, BC V6T 1Z3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manju","family":"George","sequence":"additional","affiliation":[{"name":"COLONTOWN<sup>\u00ae<\/sup>, Paltown Development Foundation 969 Diggs Road, Crownsville, MD 21032, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary A.","family":"De Vera","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, University of British Columbia, 2405 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada"},{"name":"Collaboration for Outcomes Research and Evaluation, Vancouver, BC V6T 1Z3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,21]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2020). Infertility Definitions and Terminology, World Health Organization. Available online: https:\/\/www.who.int\/health-topics\/infertility#tab=tab_3."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Milan, A. (2014). Fertility: Fewer Children, Older Moms, Statistics Canada. Available online: https:\/\/www150.statcan.gc.ca\/n1\/pub\/11-630-x\/11-630-x2014002-eng.htm.","DOI":"10.1038\/nrneph.2015.157"},{"key":"ref_3","unstructured":"Provencher, C., Milan, A., Hallman, S., and D\u2019Aoust, C. (2018). Fertility: Overview, 2012 to 2016, Statistics Canada. Available online: https:\/\/www150.statcan.gc.ca\/n1\/pub\/91-209-x\/2018001\/article\/54956-eng.pdf."},{"key":"ref_4","first-page":"626393","article-title":"A case of colorectal cancer during pregnancy: A brief review of the literature","volume":"2013","author":"Khodaverdi","year":"2013","journal-title":"Case Rep. Obstet. Gynecol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3322\/canjclin.47.1.5","article-title":"Cancer Statistics, 1997","volume":"47","author":"Parker","year":"1997","journal-title":"CA Cancer J. Clin."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1002\/cncr.29716","article-title":"Colorectal cancer outcomes and treatment patterns in patients too young for average-risk screening","volume":"122","author":"Abdelsattar","year":"2016","journal-title":"Cancer"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1001\/jamasurg.2014.1756","article-title":"Increasing disparities in the age-related incidences of colon and rectal cancers in the United States, 1975\u20132010","volume":"150","author":"Bailey","year":"2015","journal-title":"JAMA Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1001\/archinternmed.2011.602","article-title":"Young-onset colorectal cancer: Is it time to pay attention?","volume":"172","author":"You","year":"2012","journal-title":"Arch. Intern. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"djw322","DOI":"10.1093\/jnci\/djw322","article-title":"Colorectal Cancer Incidence Patterns in the United States, 1974\u20132013","volume":"109","author":"Siegel","year":"2017","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1158\/1055-9965.EPI-09-0186","article-title":"Increase in incidence of colorectal cancer among young men and women in the United States","volume":"18","author":"Siegel","year":"2009","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Din, K.S.E., Loree, J.M., Sayre, E.C., Gill, S., Brown, C.J., Dau, H., and De Vera, M.A. (2020). Trends in the epidemiology of young-onset colorectal cancer: A worldwide systematic review. BMC Cancer, 20.","DOI":"10.1186\/s12885-020-06766-9"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1097\/MEG.0000000000000863","article-title":"Colorectal cancer diagnosed during pregnancy: Systematic review and treatment pathways","volume":"29","author":"Pellino","year":"2017","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1159\/000500078","article-title":"Challenges associated with colorectal cancer in pregnancy","volume":"13","author":"Amarjothi","year":"2019","journal-title":"Case Rep. Gastroenterol."},{"key":"ref_14","first-page":"e1190","article-title":"Colorectal cancer presenting with constipation during pregnancy","volume":"9","author":"Jones","year":"2017","journal-title":"Cureus"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1002\/cncr.29917","article-title":"Young adult female cancer survivors\u2019 unmet information needs and reproductive concerns contribute to decisional conflict regarding posttreatment fertility preservation","volume":"122","author":"Benedict","year":"2016","journal-title":"Cancer"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1016\/j.pec.2016.06.019","article-title":"Communication about sexual health with breast cancer survivors: Variation among patient and provider perspectives","volume":"99","author":"Canzona","year":"2016","journal-title":"Patient Educ. Couns."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.pec.2018.10.003","article-title":"Patient-clinician communication about sexual health in breast cancer: A mixed-methods analysis of clinic dialogue","volume":"102","author":"Reese","year":"2019","journal-title":"Patient Educ. Couns."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"6011","DOI":"10.1007\/s00520-020-05446-5","article-title":"Health information seeking behaviours amon individuals with young-onset and average-onset colorectal cancer: An international cross-sectional survey","volume":"28","author":"Dau","year":"2020","journal-title":"Support. Care Cancer"},{"key":"ref_19","first-page":"e17","article-title":"Shared experiences of diagnosis and treatment of young-onset colorectal cancer: A patient-oriented qualitative study","volume":"2","author":"Araujo","year":"2020","journal-title":"J. Psychosoc. Oncol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Dau, H., Safari, A., Saad El Din, K., McTaggart-Cowan, H., Loree, J.M., Gill, S., and De Vera, M.A. (2020). Assessing how health information needs of individuals with colorectal cancer are met across the care continuum: An international cross-sectional survey. BMC Cancer, 20.","DOI":"10.1186\/s12885-020-07539-0"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Wee, M., Dau, H., Gastonguay, L., and De Vera, M.A. (2021). How do individuals with colorectal cancer perceive the term \u201ccancer survivor\u201d: A cross-sectional survey. J. Cancer Surviv., 1\u201312.","DOI":"10.1007\/s11764-021-01015-9"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1365-2648.2007.04569.x","article-title":"The qualitative content analysis process","volume":"62","author":"Elo","year":"2008","journal-title":"J. Adv. Nurs."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"CRC34","DOI":"10.2217\/crc-2020-0028","article-title":"Early-onset colorectal cancer research: Gaps and opportunities","volume":"9","author":"Nelson","year":"2020","journal-title":"Colorectal Cancer"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"CRC24","DOI":"10.2217\/crc-2020-0004","article-title":"An action plan to address the rising burden of colorectal cancer in younger adults","volume":"9","author":"Lowery","year":"2020","journal-title":"Colorectal Cancer"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"CRC18","DOI":"10.2217\/crc-2020-0011","article-title":"Pioneering a new care model for young-onset colorectal cancer: Innovations in clinical care and scientific discovery","volume":"9","author":"Biller","year":"2020","journal-title":"Colorectal Cancer"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"CRC19","DOI":"10.2217\/crc-2020-0013","article-title":"Early-onset colorectal cancer: When hoof beats are zebras","volume":"9","author":"Siegel","year":"2020","journal-title":"Colorectal Cancer"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/DCR.0b013e31820240b3","article-title":"Topic update: Effects of colorectal cancer treatments on female fertility and potential methods for fertility preservation","volume":"54","author":"Brannigan","year":"2011","journal-title":"Dis. Colon Rectum"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1093\/humupd\/7.6.535","article-title":"The effects of radiotherapy and chemotherapy on female reproduction","volume":"7","author":"Meirow","year":"2001","journal-title":"Hum. Reprod. Update"},{"key":"ref_29","first-page":"387","article-title":"Specific and non-specific symptoms of colorectal cancer and contact to general practice","volume":"32","author":"Rasmussen","year":"2015","journal-title":"Fam. Pract."},{"key":"ref_30","unstructured":"Ganze, P.A. (2007). Reproductive complications and sexual dysfunction in cancer survivors. Cancer Survivorship: Today and Tomorrow, Springer."}],"container-title":["Current Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1718-7729\/29\/2\/42\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:05:16Z","timestamp":1760133916000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1718-7729\/29\/2\/42"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,21]]},"references-count":30,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,2]]}},"alternative-id":["curroncol29020042"],"URL":"https:\/\/doi.org\/10.3390\/curroncol29020042","relation":{},"ISSN":["1718-7729"],"issn-type":[{"value":"1718-7729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,21]]}}}