{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T14:08:26Z","timestamp":1782310106148,"version":"3.54.5"},"reference-count":111,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T00:00:00Z","timestamp":1644192000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical Research Futures Fund (MRFF) Rapid Applied Research Translation Grant","award":["0000"],"award-info":[{"award-number":["0000"]}]},{"name":"Brisbane Diamantina Health Partners Cancer Theme Grant","award":["0000"],"award-info":[{"award-number":["0000"]}]},{"name":"Faculty of Health and Behavioural Sciences -Faculty of Medicine Research Collaboration Seeding Grant, The University of Queensland.","award":["0000"],"award-info":[{"award-number":["0000"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>People with multiple myeloma (MM) are second only to people with lung cancer for the poorest reported health-related quality of life (HRQoL) of all cancer types. Whether exercise can improve HRQoL in MM, where bone pain and lesions are common, requires investigation. This trial aims to evaluate the efficacy of an exercise intervention compared with control on HRQoL in people with MM. Following baseline testing, people with MM (n = 60) will be randomized to an exercise (EX) or waitlist control (WT) group. EX will complete 12-weeks of supervised (24 sessions) and unsupervised (12 sessions) individualized, modular multimodal exercise training. From weeks 12\u201352, EX continue unsupervised training thrice weekly, with one optional supervised group-based session weekly from weeks 12\u201324. The WT will be asked to maintain their current activity levels for the first 12-weeks, before completing the same protocol as EX for the following 52 weeks. Primary (patient-reported HRQoL) and secondary (bone health and pain, fatigue, cardiorespiratory fitness, muscle strength, body composition, disease response, and blood biomarkers) outcomes will be assessed at baseline, 12-, 24- and 52-weeks. Adverse events, attendance, and adherence will be recorded and cost-effectiveness analysis performed. The findings will inform whether exercise should be included as part of standard myeloma care to improve the health of this unique population.<\/jats:p>","DOI":"10.3390\/curroncol29020077","type":"journal-article","created":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T20:36:42Z","timestamp":1644266202000},"page":"901-923","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["An Individualized Exercise Intervention for People with Multiple Myeloma\u2014Study Protocol of a Randomized Waitlist-Controlled Trial"],"prefix":"10.3390","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5049-8685","authenticated-orcid":false,"given":"Jennifer L.","family":"Nicol","sequence":"first","affiliation":[{"name":"School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane 4072, Australia"},{"name":"QIMR Berghofer Medical Research Institute, Brisbane 4006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmel","family":"Woodrow","sequence":"additional","affiliation":[{"name":"Haematology, Division of Cancer, Princess Alexandra Hospital, Brisbane 4102, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent J.","family":"Cunningham","sequence":"additional","affiliation":[{"name":"School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane 4072, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Mollee","sequence":"additional","affiliation":[{"name":"Haematology, Division of Cancer, Princess Alexandra Hospital, Brisbane 4102, Australia"},{"name":"Faculty of Medicine, The University of Queensland, Brisbane 4006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Weber","sequence":"additional","affiliation":[{"name":"Haematology, Cancer Care Services, Royal Brisbane and Women\u2019s Hospital, Brisbane 4006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7860-1581","authenticated-orcid":false,"given":"Michelle D.","family":"Smith","sequence":"additional","affiliation":[{"name":"School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane 4072, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Nicol","sequence":"additional","affiliation":[{"name":"School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane 4072, Australia"},{"name":"Brisbane Clinic for Lymphoma, Myeloma and Leukaemia, Greenslopes Private Hospital, Brisbane 4120, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3159-4249","authenticated-orcid":false,"given":"Louisa G.","family":"Gordon","sequence":"additional","affiliation":[{"name":"QIMR Berghofer Medical Research Institute, Brisbane 4006, Australia"},{"name":"Faculty of Medicine, The University of Queensland, Brisbane 4006, Australia"},{"name":"Palliative Care Outcomes Centre, School of Nursing and Cancer, Queensland University of Technology, Brisbane 4059, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1134-0951","authenticated-orcid":false,"given":"Michelle M.","family":"Hill","sequence":"additional","affiliation":[{"name":"QIMR Berghofer Medical Research Institute, Brisbane 4006, Australia"},{"name":"UQ Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane 4006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5704-2741","authenticated-orcid":false,"given":"Tina L.","family":"Skinner","sequence":"additional","affiliation":[{"name":"School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane 4072, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1053\/j.seminoncol.2016.11.004","article-title":"Multiple myeloma epidemiology and survival: A unique malignancy","volume":"43","author":"Kazandjian","year":"2016","journal-title":"Semin. 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