{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:33:41Z","timestamp":1792787621367,"version":"4.5.0"},"reference-count":65,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T00:00:00Z","timestamp":1644796800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Cervical cancer is the most common gynecologic malignancy and the fourth most common cancer in women worldwide. Over the last two decades, minimally invasive surgery (MIS) emerged as the mainstay in the surgical management of cervical cancer, bringing advantages such as lower operative morbidity and shorter hospital stay compared to open surgery while maintaining comparable oncologic outcomes in numerous retrospective studies. However, in 2018, a prospective phase III randomized controlled trial, \u201cLaparoscopic Approach to Carcinoma of the Cervix (LACC)\u201d, unexpectedly reported that MIS was associated with a statistically significant poorer overall survival and disease-free survival compared to open surgery in patients with early-stage cervical cancer. Various hypotheses have been raised by the authors to try to explain these results, but the LACC trial was not powered to answer those questions. In this study, through an exhaustive literature review, we wish to explore some of the potential causes that may explain the poorer oncologic outcomes associated with MIS, including the type of MIS surgery, the size of the lesion, the impact of CO2 pneumoperitoneum, prior conization, the use of uterine manipulator, the use of protective measures, and the effect of surgical expertise\/learning curve.<\/jats:p>","DOI":"10.3390\/curroncol29020093","type":"journal-article","created":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T20:26:42Z","timestamp":1644870402000},"page":"1093-1106","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Minimally Invasive Surgery for Cervical Cancer in Light of the LACC Trial: What Have We Learned?"],"prefix":"10.3390","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0878-2177","authenticated-orcid":false,"given":"Omar","family":"Touhami","sequence":"first","affiliation":[{"name":"Gynecologic Oncology Division, Department of Obstetrics and Gynecology, Centre Int\u00e9gr\u00e9 Universitaire de Sant\u00e9 et Services Sociaux CIUSSS du Saguenay\u2014Lac-Saint-Jean, Sherbrooke University, Sherbrooke, QC J1K 2R1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Plante","sequence":"additional","affiliation":[{"name":"Gynecologic Oncology Division, L\u2019Hotel-Dieu de Qu\u00e9bec, CHU de Qu\u00e9bec, Laval University, Quebec, QC G1V 0A6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S215","DOI":"10.5005\/jp-journals-10071-23638","article-title":"Critical Analysis of a Randomized Controlled Trial","volume":"24","author":"Nimavat","year":"2020","journal-title":"Indian J. 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