{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:19:35Z","timestamp":1790036375488,"version":"4.0.1"},"reference-count":27,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T00:00:00Z","timestamp":1646179200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Lesions commonly associated with HIV infection include oral candidiasis, herpes simplex infection, oral Kaposi\u2019s sarcoma, hairy leukoplakia, periodontal diseases (linear gingival erythema and necrotizing ulcerative periodontitis), xerostomia, human papillomavirus-associated warts, aphthous ulcers, non-Hodgkin\u2019s lymphoma, histoplasmosis, carcinoma, exfoliative cheilitis, and HIV salivary gland disease. Non-Hodgkin\u2019s lymphoma (NHL) is the most common cancer in people living with HIV (PLWH), and the incidence is increased for aggressive B-cell NHL. Plasmablastic lymphoma (PbL) is a rare and aggressive B-cell malignancy that is often unresponsive to chemotherapy and usually has a poor prognosis. We hereby present the case of a patient with a recent history of COVID-19 infection who was diagnosed with HIV and NHL, with manifestations in the oral cavity and a favorable evolution after the introduction of antiviral therapy, specific chemotherapy, and radiotherapy. Dental expertise is necessary for the appropriate management of oral manifestations of HIV infection or AIDS, and lymphoma should be included in the differential diagnosis of any oral lesions.<\/jats:p>","DOI":"10.3390\/curroncol29030129","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T08:37:16Z","timestamp":1646210236000},"page":"1537-1543","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A Rare Case of Plasmablastic Lymphoma in a Patient with HIV and SARS-CoV-2 Infections"],"prefix":"10.3390","volume":"29","author":[{"given":"Adriana Teodora","family":"Campeanu","sequence":"first","affiliation":[{"name":"Doctoral School, \u201cOvidius\u201d University of Constanta, 900470 Constanta, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4679-899X","authenticated-orcid":false,"given":"Elena","family":"Dumea","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u201cOvidius\u201d University of Constanta, 900470 Constanta, Romania"},{"name":"Clinical Infectious Diseases Hospital Constanta, 900709 Constanta, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihaela","family":"Rus","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u201cOvidius\u201d University of Constanta, 900470 Constanta, Romania"},{"name":"Faculty of Psychology, \u201cOvidius\u201d University of Constanta, 900527 Constanta, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Fodor","sequence":"additional","affiliation":[{"name":"Clinical Infectious Diseases Hospital Constanta, 900709 Constanta, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita Cristina","family":"Ionescu","sequence":"additional","affiliation":[{"name":"Doctoral School, \u201cOvidius\u201d University of Constanta, 900470 Constanta, Romania"},{"name":"Oncological Institute, Prof. Dr. Alexandru Trestioreanu, 022328 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2386-543X","authenticated-orcid":false,"given":"Elena","family":"Mocanu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u201cOvidius\u201d University of Constanta, 900470 Constanta, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihaela","family":"Botnarciuc","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u201cOvidius\u201d University of Constanta, 900470 Constanta, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0395-6713","authenticated-orcid":false,"given":"Irina Magdalena","family":"Dumitru","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u201cOvidius\u201d University of Constanta, 900470 Constanta, Romania"},{"name":"Clinical Infectious Diseases Hospital Constanta, 900709 Constanta, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s11904-008-0002-8","article-title":"Oral manifestations associated with HIV infection","volume":"5","author":"Nokta","year":"2008","journal-title":"Curr. HIV\/AIDS Rep."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"653","DOI":"10.21149\/9834","article-title":"Prevalence and risk factors for oral human papillomavirus infection in Mexican HIV-infected men","volume":"60","year":"2018","journal-title":"Salud Publica Mex."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1111\/ijd.14440","article-title":"Mucocutaneous manifestations of human immunodeficiency virus (HIV) infection in children in relation to the degree of immunosuppression","volume":"58","author":"Britto","year":"2019","journal-title":"Int. J. Dermatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4103\/0976-237X.62510","article-title":"Oral manifestations of HIV","volume":"1","author":"Bajpai","year":"2010","journal-title":"Contemp. Clin. Dent."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/jop.12304","article-title":"Oral innate immunity in HIV infection in HAART era","volume":"45","author":"Nittayananta","year":"2016","journal-title":"J. Oral Pathol. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1034\/j.1601-0825.2002.00017.x","article-title":"Oral fungal and bacterial infections in HIV-infected individuals: An overview in Africa","volume":"8","author":"Hodgson","year":"2002","journal-title":"Oral Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"171","DOI":"10.6004\/jnccn.2019.0008","article-title":"AIDS-Related Kaposi Sarcoma, Version 2.2019, NCCN Clinical Practice Guidelines in Oncology","volume":"17","author":"Reid","year":"2019","journal-title":"J. Natl. Compr. Cancer Netw."},{"key":"ref_8","first-page":"209","article-title":"Risk factors for Kaposi Sarcoma in HIV infected patients","volume":"30","author":"Dumitru","year":"2014","journal-title":"Acta Med. Mediterr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3653","DOI":"10.37358\/RC.18.12.6812","article-title":"Synchronous association of two types of indolent lymphomas","volume":"69","author":"Aschie","year":"2018","journal-title":"Rev. Chim."},{"key":"ref_10","first-page":"291","article-title":"A case-control study of non-AIDS-defining cancers in a prospective cohort of HIV-infected patients","volume":"150","author":"Camino","year":"2018","journal-title":"Med. Clin."},{"key":"ref_11","first-page":"354","article-title":"Primary Extranodal Non-hodgking Lymphoma of the Head and Neck in Patients with Acquired Immunodeficiency Syndrome: A clinicopathologic Study of 24 patients in a Single Hospital of Infectious Diseases in Argentina","volume":"19","author":"Corti","year":"2015","journal-title":"Int. Arch. Otorhinolaryngol."},{"key":"ref_12","first-page":"665","article-title":"Oral manifestations of lymphoma: A systematic review","volume":"10","author":"Antunes","year":"2016","journal-title":"Ecancermedicalscience"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.bulcan.2021.03.014","article-title":"Human immunodeficiency virus and lymphoma","volume":"108","author":"Tazi","year":"2021","journal-title":"Bull. Cancer"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1080\/10428194.2017.1387912","article-title":"Survival of patients with CD20-negative variants of large B-cell lymphoma: An analysis of the National Cancer Data Base","volume":"59","author":"Qunaj","year":"2018","journal-title":"Leuk. Lymphoma"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/S0753-3322(01)00092-0","article-title":"Epstein-Barr virus and HIV-AIDS-associated diseases","volume":"55","author":"McClain","year":"2001","journal-title":"Biomed. Pharmacother."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"10902","DOI":"10.1038\/s41598-021-90351-y","article-title":"Positive Epstein-Barr virus detection in coronavirus disease 2019 (COVID-19) patients","volume":"11","author":"Chen","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2147\/BLCTT.S142814","article-title":"Plasmablastic lymphoma: Current perspectives","volume":"8","author":"Lopez","year":"2018","journal-title":"Blood Lymphat. Cancer"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"63","DOI":"10.47162\/RJME.62.1.06","article-title":"Assessment of programmed death-ligand 1 receptor immunohistochemical expression and its association with tumor-infiltrating lymphocytes and p53 status in triple-negative breast cancer","volume":"62","author":"Deacu","year":"2021","journal-title":"Rom. J. Morphol. Embryol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1093\/annonc\/mdw684","article-title":"Clinical characteristics and prognostic factors of plasmablastic lymphoma patients: Analysis of 135 patients from the LYSA group","volume":"28","author":"Tchernonog","year":"2017","journal-title":"Ann. Oncol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1093\/cid\/ciu076","article-title":"HIV Viremia and Incidence of Non-Hodgkin Lymphoma in Patients Successfully Treated with Antiretroviral Therapy","volume":"58","author":"Achenbach","year":"2014","journal-title":"Clin. Infect. Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1158\/1055-9965.EPI-11-0777","article-title":"HIV infection, immunodeficiency, viral replication, and the risk of cancer","volume":"20","author":"Silverberg","year":"2011","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1097\/CCO.0000000000000713","article-title":"Viral strategies for circumventing p53: The case of severe acute respiratory syndrome coronavirus","volume":"33","author":"Cardozo","year":"2021","journal-title":"Curr. Opin. Oncol."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Habibzadeh, P., Dastsooz, H., Eshraghi, M., \u0141os, M.J., Klionsky, D.J., and Ghavami, S. (2021). Autophagy: The Potential Link between SARS-CoV-2 and Cancer. Cancers, 13.","DOI":"10.3390\/cancers13225721"},{"key":"ref_24","first-page":"e2020047","article-title":"Oncolytic effect of SARS-CoV2 in a patient with NK lymphoma","volume":"91","author":"Pasin","year":"2020","journal-title":"Acta Biomed."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/bjh.17116","article-title":"SARS-CoV-2-induced remission of Hodgkin lymphoma","volume":"192","author":"Challenor","year":"2021","journal-title":"Br. J. Haematol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"17588359211011455","DOI":"10.1177\/17588359211011455","article-title":"Unexpected tumor reduction in metastatic colorectal cancer patients during SARS-Cov-2 infection","volume":"13","author":"Ottaiano","year":"2021","journal-title":"Ther. Adv. Med. Oncol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"198","DOI":"10.18683\/germs.2019.1178","article-title":"Extended Consensus Group. Consensus statement on the assessment of comorbidities in people living with HIVin Romania","volume":"9","author":"Mircescu","year":"2019","journal-title":"Germs"}],"container-title":["Current Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1718-7729\/29\/3\/129\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:30:34Z","timestamp":1760135434000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1718-7729\/29\/3\/129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,2]]},"references-count":27,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,3]]}},"alternative-id":["curroncol29030129"],"URL":"https:\/\/doi.org\/10.3390\/curroncol29030129","relation":{},"ISSN":["1718-7729"],"issn-type":[{"value":"1718-7729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,2]]}}}