{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:48:15Z","timestamp":1791679695107,"version":"4.3.4"},"reference-count":47,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T00:00:00Z","timestamp":1646265600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Background: OncoSim-Breast is a Canadian breast cancer simulation model to evaluate breast cancer interventions. This paper aims to describe the OncoSim-Breast model and how well it reproduces observed breast cancer trends. Methods: The OncoSim-Breast model simulates the onset, growth, and spread of invasive and ductal carcinoma in situ tumours. It combines Canadian cancer incidence, mortality, screening program, and cost data to project population-level outcomes. Users can change the model input to answer specific questions. Here, we compared its projections with observed data. First, we compared the model\u2019s projected breast cancer trends with the observed data in the Canadian Cancer Registry and from Vital Statistics. Next, we replicated a screening trial to compare the model\u2019s projections with the trial\u2019s observed screening effects. Results: OncoSim-Breast\u2019s projected incidence, mortality, and stage distribution of breast cancer were close to the observed data in the Canadian Cancer Registry and from Vital Statistics. OncoSim-Breast also reproduced the breast cancer screening effects observed in the UK Age trial. Conclusions: OncoSim-Breast\u2019s ability to reproduce the observed population-level breast cancer trends and the screening effects in a randomized trial increases the confidence of using its results to inform policy decisions related to early detection of breast cancer.<\/jats:p>","DOI":"10.3390\/curroncol29030136","type":"journal-article","created":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T09:24:53Z","timestamp":1646299493000},"page":"1619-1633","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The OncoSim-Breast Cancer Microsimulation Model"],"prefix":"10.3390","volume":"29","author":[{"given":"Jean H. E.","family":"Yong","sequence":"first","affiliation":[{"name":"Canadian Partnership Against Cancer, Toronto, ON M5H 1J8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Nadeau","sequence":"additional","affiliation":[{"name":"Statistics Canada, Ottawa, ON K1A 0T6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William M.","family":"Flanagan","sequence":"additional","affiliation":[{"name":"Statistics Canada, Ottawa, ON K1A 0T6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3263-2649","authenticated-orcid":false,"given":"Andrew J.","family":"Coldman","sequence":"additional","affiliation":[{"name":"British Columbia Cancer Research Institute, Vancouver, BC V5Z 1L3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Asakawa","sequence":"additional","affiliation":[{"name":"Statistics Canada, Ottawa, ON K1A 0T6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rochelle","family":"Garner","sequence":"additional","affiliation":[{"name":"Statistics Canada, Ottawa, ON K1A 0T6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"Canadian Partnership Against Cancer, Toronto, ON M5H 1J8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7227-9915","authenticated-orcid":false,"given":"Martin J.","family":"Yaffe","sequence":"additional","affiliation":[{"name":"Sunnybrook Research Institute, Toronto, ON M4N 3M5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony B.","family":"Miller","sequence":"additional","affiliation":[{"name":"Dalla Lana School of Public Health, University of Toronto, Toronto, ON M5T 3M7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"305","DOI":"10.7326\/0003-4819-137-5_Part_1-200209030-00005","article-title":"The Canadian National Breast Screening Study-1: Breast cancer mortality after 11 to 16 years of follow-up: A randomized screening trial of mammography in women age 40 to 49 years","volume":"137","author":"Miller","year":"2002","journal-title":"Ann. 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