{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:13:57Z","timestamp":1790828037604,"version":"4.1.0"},"reference-count":63,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T00:00:00Z","timestamp":1649980800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>EBV-positive mucocutaneous ulcer (EBV-MCU) was classified as a rare new entity of the lymphoproliferative B-cell diseases by the WHO in 2017 and must be distinguished from head and neck squamous cell carcinoma by early biopsy. The aim of the study is to raise awareness of the disease and to give a review of the current literature and a recommendation for EBV-MCU management. All EBV-MCU cases of the head and neck region published so far were included. We also report a case of a pharyngeal EBV-MCU in an 89-year-old patient who was immunosuppressed by chronic lymphatic leukaemia\/small lymphocytic lymphoma (CLL\/SLL). In contrast to all previously described cases, histopathology showed a co-infiltration of EBV-MCU and CLL\/SLL. A total of 181 cases were identified on PubMed and summarised. EBV-MCU was predominantly caused by immunosuppressive drug therapy. Complete remission could be achieved in 68% of cases and was mainly attributed to a reduction of the immunosuppressive therapy alone (72%). However, some severe cases require more aggressive treatment. Regarding the various histopathologic similarities to other lymphoproliferative disorders, the diagnosis of EBV-MCU can be misleading, with a great impact on patient care and treatment. This diagnosis must be made with caution and requires a combination of clinical, morphological and immunophenotypic features.<\/jats:p>","DOI":"10.3390\/curroncol29040224","type":"journal-article","created":{"date-parts":[[2022,4,16]],"date-time":"2022-04-16T07:42:41Z","timestamp":1650094961000},"page":"2749-2767","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Co-Occurrence of EBV-Positive Mucocutaneous Ulcer (EBV-MCU) and CLL\/SLL in the Head and Neck Region"],"prefix":"10.3390","volume":"29","author":[{"given":"Patricia","family":"Bott","sequence":"first","affiliation":[{"name":"Division of Otorhinolaryngology, Head and Neck Surgery, University of Oldenburg, Steinweg 13-17, 26122 Oldenburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilske","family":"Oschlies","sequence":"additional","affiliation":[{"name":"Hematopathology Section and Lymphnode Registry, Department of Pathology, University Hospitals Schleswig-Holstein, Christian-Albrecht-University, Arnold-Heller-Str. 3\/14, 24105 Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1881-4179","authenticated-orcid":false,"given":"Andreas","family":"Radeloff","sequence":"additional","affiliation":[{"name":"Division of Otorhinolaryngology, Head and Neck Surgery, University of Oldenburg, Steinweg 13-17, 26122 Oldenburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen","family":"Loewenthal","sequence":"additional","affiliation":[{"name":"Division of Otorhinolaryngology, Head and Neck Surgery, University of Oldenburg, Steinweg 13-17, 26122 Oldenburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1097\/PAS.0b013e3181cf8622","article-title":"EBV positive mucocutaneous ulcer\u2013a study of 26 cases associated with various sources of immunosuppression","volume":"34","author":"Dojcinov","year":"2010","journal-title":"Am. 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