{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T02:01:36Z","timestamp":1762048896626,"version":"build-2065373602"},"reference-count":57,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T00:00:00Z","timestamp":1651190400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Inuit are the Indigenous Arctic peoples and residents of the Canadian territory of Nunavut who have the highest global rate of lung cancer. Given lung cancer\u2019s mortality, histological and genomic characterization was undertaken to better understand the disease biology. We retrospectively studied all Inuit cases from Nunavut\u2019s Qikiqtani (Baffin) region, referred to the Ottawa Hospital Cancer Center between 2001 and 2011. Demographics were compiled from medical records and tumor samples underwent pathologic\/histologic confirmation. Tumors were analyzed by next generation sequencing (NGS) with a cancer hotspot mutation panel. Of 98 patients, the median age was 66 years and 61% were male. Tobacco use was reported in 87%, and 69% had a history of lung disease (tuberculosis or other). Histological types were: non-small cell lung carcinoma (NSCLC), 81%; small cell lung carcinoma, 16%. Squamous cell carcinoma (SCC) represented 65% of NSCLC. NGS on 55 samples demonstrated mutation rates similar to public lung cancer datasets. In SCC, the STK11 F354L mutation was observed at higher frequency than previously reported. This is the first study to characterize the histologic\/genomic profiles of lung cancer in this population. A high incidence of SCC, and an elevated rate of STK11 mutations distinguishes this group from the North American population.<\/jats:p>","DOI":"10.3390\/curroncol29050258","type":"journal-article","created":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T16:49:57Z","timestamp":1651250997000},"page":"3171-3186","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Histologic and Genotypic Characterization of Lung Cancer in the Inuit Population of the Eastern Canadian Arctic"],"prefix":"10.3390","volume":"29","author":[{"given":"Glenwood D.","family":"Goss","sequence":"first","affiliation":[{"name":"The Ottawa Hospital Research Institute, 501 Smyth Rd, Ottawa, ON K1H 8L6, Canada"},{"name":"Division of Medical Oncology, Department of Medicine, The Ottawa Hospital Cancer Center and the University of Ottawa, ON K1N 6N5, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna N.","family":"Spaans","sequence":"additional","affiliation":[{"name":"The Ottawa Hospital Research Institute, 501 Smyth Rd, Ottawa, ON K1H 8L6, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Huntsman","sequence":"additional","affiliation":[{"name":"Imagia Canexia Health, Suite #204 Donald Rix Building, 2389 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada"},{"name":"Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Asmis","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Medicine, The Ottawa Hospital Cancer Center and the University of Ottawa, ON K1N 6N5, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5151-8198","authenticated-orcid":false,"given":"Natalie M.","family":"Andrews Wright","sequence":"additional","affiliation":[{"name":"The Ottawa Hospital Research Institute, 501 Smyth Rd, Ottawa, ON K1H 8L6, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Duciaume","sequence":"additional","affiliation":[{"name":"The Ottawa Hospital Research Institute, 501 Smyth Rd, Ottawa, ON K1H 8L6, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pardeep","family":"Kaurah","sequence":"additional","affiliation":[{"name":"Imagia Canexia Health, Suite #204 Donald Rix Building, 2389 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada"},{"name":"Department of Medical Genetics, Faculty of Medicine, University of British Columbia, and Hereditary Cancer Program, BC Cancer, Vancouver, BC V5Z 4E6, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth R.","family":"Miller","sequence":"additional","affiliation":[{"name":"Imagia Canexia Health, Suite #204 Donald Rix Building, 2389 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7531-1378","authenticated-orcid":false,"given":"Shantanu","family":"Banerji","sequence":"additional","affiliation":[{"name":"CancerCare Manitoba Research Institute, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0V9, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harmanjatinder S.","family":"Sekhon","sequence":"additional","affiliation":[{"name":"The Ottawa Hospital Research Institute, 501 Smyth Rd, Ottawa, ON K1H 8L6, Canada"},{"name":"Department of Pathology, The Ottawa Hospital and the University of Ottawa, Ottawa, ON K1N 6N5, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcio M.","family":"Gomes","sequence":"additional","affiliation":[{"name":"The Ottawa Hospital Research Institute, 501 Smyth Rd, Ottawa, ON K1H 8L6, Canada"},{"name":"Department of Pathology, The Ottawa Hospital and the University of Ottawa, Ottawa, ON K1N 6N5, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,29]]},"reference":[{"key":"ref_1","unstructured":"(2022, March 15). 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