{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T19:56:17Z","timestamp":1780084577817,"version":"3.54.0"},"reference-count":24,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T00:00:00Z","timestamp":1656460800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Myelodysplastic syndromes (MDS) and Waldenstrom\u2019s macroglobulinemia (WM) are rarely synchronous. Ineffective myelopoiesis\/hematopoiesis with clonal unilineage or multilineage dysplasia and cytopenias characterize MDS. Despite a myeloid origin, MDS can sometimes lead to decreased production, abnormal apoptosis or dysmaturation of B cells, and the development of lymphoma. WM includes bone marrow involvement by lymphoplasmacytic lymphoma (LPL) secreting monoclonal immunoglobulin M (IgM) with somatic mutation (L265P) of myeloid differentiation primary response 88 gene (MYD88) in 80\u201390%, or various mutations of C-terminal domain of the C-X-C chemokine receptor type 4 (CXCR4) gene in 20\u201340% of cases. A unique, progressive case of concurrent MDS and WM with several somatic mutations (some unreported before) and a novel balanced reciprocal translocation between chromosomes 10 and 13 is presented below.<\/jats:p>","DOI":"10.3390\/curroncol29070363","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T20:47:56Z","timestamp":1656535676000},"page":"4587-4592","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Concurrent Waldenstrom\u2019s Macroglobulinemia and Myelodysplastic Syndrome with a Sequent t(10;13)(p13;q22) Translocation"],"prefix":"10.3390","volume":"29","author":[{"given":"Peter A.","family":"DeRosa","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Maryland Medical System, Baltimore, MD 21201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle C.","family":"Roche","sequence":"additional","affiliation":[{"name":"Department of Medicine, The George Washington University, Washington, DC 20037, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1438-9665","authenticated-orcid":false,"given":"Victor E.","family":"Nava","sequence":"additional","affiliation":[{"name":"Department of Pathology, The George Washington University, Washington, DC 20037, USA"},{"name":"Department of Pathology, Veterans Health Administration Medical Center, Washington, DC 20422, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunita","family":"Singh","sequence":"additional","affiliation":[{"name":"Quest Diagnostics, Chantilly, VA 20151, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Ling","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology, The George Washington University, Washington, DC 20037, USA"},{"name":"Department of Pathology, Veterans Health Administration Medical Center, Washington, DC 20422, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, The George Washington University, Washington, DC 20037, USA"},{"name":"Department of Hematology and Oncology, Veterans Health Administration Medical Center, Washington, DC 20422, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1056\/NEJMra0902908","article-title":"Myelodysplastic syndromes","volume":"361","author":"Tefferi","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"443","DOI":"10.3322\/caac.21357","article-title":"2016 US lymphoid malignancy statistics by World Health Organization subtypes","volume":"66","author":"Teras","year":"2016","journal-title":"CA Cancer J. Clin."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1053\/sonc.2003.50082","article-title":"Clinicopathological definition of Waldenstrom\u2019s macroglobulinemia: Consensus panel recommendations from the Second International Workshop on Waldenstrom\u2019s Macroglobulinemia","volume":"30","author":"Owen","year":"2003","journal-title":"Semin. Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0165-4608(01)00538-6","article-title":"Interstitial deletion of 20q in a patient with Waldenstrom macroglobulinemia following chemotherapy","volume":"132","author":"Blann","year":"2002","journal-title":"Cancer Genet Cytogenet."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.cancergencyto.2006.03.013","article-title":"Deletion (20q) as the sole abnormality in Waldenstrom macroglobulinemia suggests distinct pathogenesis of 20q11 anomaly","volume":"169","author":"Liu","year":"2006","journal-title":"Cancer Genet Cytogenet."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1179\/102453311X12953015767338","article-title":"Non-random chromosomal deletion clustering at 20q in Waldenstrom macroglobulinemia","volume":"16","author":"Kitahara","year":"2011","journal-title":"Hematology"},{"key":"ref_7","first-page":"2744","article-title":"Beta(2)-microglobulin identified as an apoptosis-inducing factor and its characterization","volume":"94","author":"Mori","year":"1999","journal-title":"Blood"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nature10688","article-title":"FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas","volume":"481","author":"Duan","year":"2012","journal-title":"Nature"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1111\/cas.14386","article-title":"Biallelic loss of FAM46C triggers tumor growth with concomitant activation of Akt signaling in multiple myeloma cells","volume":"111","author":"Kanasugi","year":"2020","journal-title":"Cancer Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"4462","DOI":"10.1182\/blood-2011-10-384768","article-title":"Progression in smoldering Waldenstrom macroglobulinemia: Long-term results","volume":"119","author":"Kyle","year":"2012","journal-title":"Blood"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1053\/sonc.2003.50063","article-title":"Familial Waldenstrom\u2019s macroglobulinemia","volume":"30","author":"McMaster","year":"2003","journal-title":"Semin. Oncol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1182\/blood-2005-12-4916","article-title":"Diagnostic application of flow cytometric characteristics of CD34+ cells in low-grade myelodysplastic syndromes","volume":"108","author":"Ogata","year":"2006","journal-title":"Blood"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/leu.2013.124","article-title":"Multiparameter flow cytometry for the identification of the Waldenstrom\u2019s clone in IgM-MGUS and Waldenstrom\u2019s Macroglobulinemia: New criteria for differential diagnosis and risk stratification","volume":"28","author":"Paiva","year":"2014","journal-title":"Leukemia"},{"key":"ref_14","unstructured":"Swerdlow, S.H., World Health Organization, and International Agency for Research on Cancer (2017). WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1093\/annonc\/mdj111","article-title":"Characterization of familial Waldenstrom\u2019s macroglobulinemia","volume":"17","author":"Treon","year":"2006","journal-title":"Ann. Oncol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1053\/sonc.2003.50039","article-title":"Treatment recommendations in Waldenstrom\u2019s macroglobulinemia: Consensus panel recommendations from the Second International Workshop on Waldenstrom\u2019s Macroglobulinemia","volume":"30","author":"Gertz","year":"2003","journal-title":"Semin. Oncol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.18632\/aging.100855","article-title":"The PTEN tumor suppressor gene and its role in lymphoma pathogenesis","volume":"7","author":"Wang","year":"2015","journal-title":"Aging"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.neo.2018.03.002","article-title":"Clinical Significance of PTEN Deletion, Mutation, and Loss of PTEN Expression in De Novo Diffuse Large B-Cell Lymphoma","volume":"20","author":"Wang","year":"2018","journal-title":"Neoplasia"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1038\/s41467-020-15943-0","article-title":"Multi-model functionalization of disease-associated PTEN missense mutations identifies multiple molecular mechanisms underlying protein dysfunction","volume":"11","author":"Post","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.ebiom.2016.04.038","article-title":"Genomic Profiling of Adult and Pediatric B-cell Acute Lymphoblastic Leukemia","volume":"8","author":"Liu","year":"2016","journal-title":"EBioMedicine"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1182\/blood.V86.5.1911.bloodjournal8651911","article-title":"13q Deletions in Lymphoid Malignancies","volume":"86","author":"Liu","year":"1995","journal-title":"Blood"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/(SICI)1098-2264(199907)25:3<222::AID-GCC4>3.0.CO;2-C","article-title":"Myeloid- and lymphoid-specific breakpoint cluster regions in chromosome band 13q14 in acute leukemia","volume":"25","author":"Coignet","year":"1999","journal-title":"Genes Chromosomes Cancer"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1046\/j.1365-2257.2002.00456.x","article-title":"Chromosomal and genetic abnormalities in myeloma","volume":"24","author":"Joy","year":"2002","journal-title":"Clin. Lab. Haematol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.cell.2018.02.060","article-title":"Comprehensive Characterization of Cancer Driver Genes and Mutations","volume":"173","author":"Bailey","year":"2018","journal-title":"Cell"}],"container-title":["Current Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1718-7729\/29\/7\/363\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:40:07Z","timestamp":1760139607000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1718-7729\/29\/7\/363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,29]]},"references-count":24,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022,7]]}},"alternative-id":["curroncol29070363"],"URL":"https:\/\/doi.org\/10.3390\/curroncol29070363","relation":{},"ISSN":["1718-7729"],"issn-type":[{"value":"1718-7729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,29]]}}}