{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T04:42:38Z","timestamp":1793853758057,"version":"4.6.1"},"reference-count":26,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T00:00:00Z","timestamp":1656460800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Over the last few years, diffusion-weighted imaging (DWI) has become increasingly relevant in the diagnostic assessment of peritoneal carcinomatosis. The aim of this study was to investigate the benefits of high-b DWI (c-DWI) compared to standard DWI in patients with peritoneal carcinomatosis. A cohort of 40 patients with peritoneal carcinomatosis were included in this retrospective study. DWI was performed with b-values of 50, 400, and 800 or 1000 s\/mm\u00b2 on a 1.5-T magnetic resonance imaging (MRI) scanner. C-DWI was calculated using a mono-exponential model with high b-values of 1000, 2000, 3000, 4000, and 5000 s\/mm\u00b2. All c-DWI images with high b-values were compared in terms of volume, detectability of peritoneal lesions, and image quality with the DWI sequence acquired with a b-value of 800 or 1000 s\/mm\u00b2 by two readers. In the group with a b-value of 800 s\/mm\u00b2, there was no statistically significant difference in terms of lesion volume. In the second group with a b-value of 1000 s\/mm\u00b2, peritoneal carcinomatosis lesions were statistically significantly larger than in the c-DWI with a- high b-value of 2000 s\/mm\u00b2 (median 7 cm\u00b3, range 1\u201326 cm\u00b3vs. median 6 cm\u00b3, range 1\u201383 cm\u00b3, p &lt; 0.05). In both groups, there was a marked decrease in the detectability of peritoneal lesions starting at b = 2000 s\/mm\u00b2. In addition, image quality decreased noticeably from c-DWI at b = 3000 s\/mm\u00b2. In both groups, all images with high b-values at b = 4000 s\/mm\u00b2 and 5000 s\/mm\u00b2 were not diagnostically valuable due to poor image quality. The c-DWI technique offers good diagnostic performance without additional scanning time. High c-DWI b-values up to b = 1000 s\/mm\u00b2 provide comparable detectability of peritoneal carcinomatosis compared to standard DWI. Higher b-values over 1500 s\/mm\u00b2 result in lower image quality, which might lead to misdiagnosis.<\/jats:p>","DOI":"10.3390\/curroncol29070364","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T20:47:56Z","timestamp":1656535676000},"page":"4593-4603","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Magnetic Resonance Imaging of Peritoneal Carcinomatosis: Evaluation of High b-Value Computed Diffusion-Weighted Imaging"],"prefix":"10.3390","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3696-1471","authenticated-orcid":false,"given":"Maxime","family":"Ablefoni","sequence":"first","affiliation":[{"name":"Department of Paediatric Radiology, University of Leipzig, Liebigstra\u00dfe 20a, 04103 Leipzig, Germany"},{"name":"Department of Diagnostic and Interventional Radiology, University of Leipzig, Liebigstra\u00dfe 20, 04103 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Leonhardi","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, University of Leipzig, Liebigstra\u00dfe 20, 04103 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantin","family":"Ehrengut","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, University of Leipzig, Liebigstra\u00dfe 20, 04103 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Mehdorn","sequence":"additional","affiliation":[{"name":"Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, 04103 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Sucher","sequence":"additional","affiliation":[{"name":"Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, 04103 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7423-713X","authenticated-orcid":false,"given":"Ines","family":"Gockel","sequence":"additional","affiliation":[{"name":"Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, 04103 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3313-3208","authenticated-orcid":false,"given":"Timm","family":"Denecke","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, University of Leipzig, Liebigstra\u00dfe 20, 04103 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8489-706X","authenticated-orcid":false,"given":"Hans-Jonas","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, University of Leipzig, Liebigstra\u00dfe 20, 04103 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1055\/s-0031-1281979","article-title":"State-of-the-Art-Bildgebung bei Peritonealkarzinose [State-of-the-art imaging of peritoneal carcinomatosis]","volume":"184","author":"Pfannenberg","year":"2012","journal-title":"Rofo"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"6979","DOI":"10.3748\/wjg.v19.i41.6979","article-title":"Peritoneal carcinomatosis","volume":"19","author":"Coccolini","year":"2013","journal-title":"World J. 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