{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T03:22:41Z","timestamp":1792466561314,"version":"4.5.0"},"reference-count":43,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T00:00:00Z","timestamp":1657065600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Individualized survival prognostic models for symptomatic patients with appendicular metastatic bone disease are key to guiding clinical decision-making for the orthopedic surgeon. Several prognostic models have been developed in recent years; however, most orthopedic surgeons have not incorporated these models into routine practice. This is possibly due to uncertainty concerning their accuracy and the lack of comparison publications and recommendations. Our aim was to conduct a review and quality assessment of these models. A computerized literature search in MEDLINE, EMBASE and PubMed up to February 2022 was done, using keywords: \u201cBone metastasis\u201d, \u201csurvival\u201d, \u201cextremity\u201d and \u201cprognosis\u201d. We evaluated each model\u2019s performance, assessing the estimated discriminative power and calibration accuracy for the analyzed patients. We included 11 studies out of the 1779 citations initially retrieved. The 11 studies included seven different models for estimating survival. Among externally validated survival prediction scores, PATHFx 3.0, 2013-SPRING and potentially Optimodel were found to be the best models in terms of performance. Currently, it is still a challenge to recommend any of the models as the standard for predicting survival for these patients. However, some models show better performance status and other quality characteristics. We recommend future, large, multicenter, prospective studies to compare between PATHfx 3.0, SPRING 2013 and OptiModel using the same external validation dataset.<\/jats:p>","DOI":"10.3390\/curroncol29070373","type":"journal-article","created":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T09:41:10Z","timestamp":1657100470000},"page":"4703-4716","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The Prediction of Survival after Surgical Management of Bone Metastases of the Extremities\u2014A Comparison of Prognostic Models"],"prefix":"10.3390","volume":"29","author":[{"given":"Ofir","family":"Ben Gal","sequence":"first","affiliation":[{"name":"Department of Musculoskeletal Oncology, Glasgow Royal Infirmary, 84 Castle Street, Glasgow G4 0SF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terrence Chi Fang","family":"Soh","sequence":"additional","affiliation":[{"name":"University Hospital Hairmyres, 218 Eaglesham Rd, East Kilbride, Glasgow G75 8RG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Vaughan","sequence":"additional","affiliation":[{"name":"Department of Musculoskeletal Oncology, Glasgow Royal Infirmary, 84 Castle Street, Glasgow G4 0SF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viswanath","family":"Jayasanker","sequence":"additional","affiliation":[{"name":"Department of Musculoskeletal Oncology, Glasgow Royal Infirmary, 84 Castle Street, Glasgow G4 0SF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Mahendra","sequence":"additional","affiliation":[{"name":"Department of Musculoskeletal Oncology, Glasgow Royal Infirmary, 84 Castle Street, Glasgow G4 0SF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Musculoskeletal Oncology, Glasgow Royal Infirmary, 84 Castle Street, Glasgow G4 0SF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s00590-016-1857-9","article-title":"Treatment for long bone metastases based on a systematic literature review","volume":"27","author":"Errani","year":"2017","journal-title":"Eur. 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