{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T19:27:45Z","timestamp":1762543665652,"version":"build-2065373602"},"reference-count":31,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T00:00:00Z","timestamp":1657152000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Canadian Cancer Society","award":["705797"],"award-info":[{"award-number":["705797"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>There has been an increasing interest in patient-reported outcome (PRO) measures in both the clinical and research settings to improve the quality of life among patients and to identify when clinical intervention may be needed. The primary purpose of this prospective study was to validate an acute breast skin toxicity PRO measure across a broad sample of patient body types undergoing radiation therapy. Between August 2018 and September 2019, 134 women undergoing adjuvant breast radiotherapy (RT) consented to completing serial PRO measures both during and post-RT treatment and to having their skin assessed by trained trial radiation therapists. There was high patient compliance, with 124 patients (92.5%) returning to the clinic post-RT for at least one staff skin assessment. Rates of moist desquamation (MD) in the infra-mammary fold (IMF) by PRO were compared with skin assessments completed by trial radiation therapists. There was high sensitivity (86.5%) and good specificity (79.4%) between PRO and staff-reported presence of MD in the IMF, and there was a moderate correlation between the peak severity of the MD reported by PRO and assessed by staff (rho = 0.61, p &lt; 0.001). This prospective study validates a new PRO measure to monitor the presence of MD in the IMF among women receiving breast RT.<\/jats:p>","DOI":"10.3390\/curroncol29070376","type":"journal-article","created":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T07:51:56Z","timestamp":1657180316000},"page":"4734-4747","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Validation of a Patient-Reported Outcome Measure for Moist Desquamation among Breast Radiotherapy Patients"],"prefix":"10.3390","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1341-5147","authenticated-orcid":false,"given":"Cheryl","family":"Duzenli","sequence":"first","affiliation":[{"name":"Department of Medical Physics, BC Cancer, Vancouver, BC V5Z 4E6, Canada"},{"name":"Department of Surgery, Division of Radiation Oncology and Developmental Radiotherapeutics, University of British Columbia, Vancouver, BC V5Z 1M9, Canada"},{"name":"Department of Physics and Astronomy, University of British Columbia, Vancouver, BC V6T 1Z1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa K.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Radiation Oncology and Developmental Radiotherapeutics, University of British Columbia, Vancouver, BC V5Z 1M9, Canada"},{"name":"Department of Radiation Oncology, BC Cancer, Vancouver, BC V5Z 4E6, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodora","family":"Koulis","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Radiation Oncology and Developmental Radiotherapeutics, University of British Columbia, Vancouver, BC V5Z 1M9, Canada"},{"name":"Department of Radiation Oncology, BC Cancer, Victoria, BC V8R 6V5, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheri","family":"Grahame","sequence":"additional","affiliation":[{"name":"Department of Radiation Therapy, BC Cancer, Vancouver, BC V5Z 4E6, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel","family":"Singer","sequence":"additional","affiliation":[{"name":"School of Population and Public Health, University of British Columbia, Vancouver, BC V6T 1Z3, Canada"},{"name":"Centre for Health Evaluation and Outcome Sciences, St. Paul\u2019s Hospital, Vancouver, BC V6Z 1Y6, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Radiation Therapy, BC Cancer, Prince George, BC V2M 7E9, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josslynn","family":"Spence","sequence":"additional","affiliation":[{"name":"Department of Radiation Therapy, BC Cancer, Prince George, BC V2M 7E9, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terry","family":"Lee","sequence":"additional","affiliation":[{"name":"Centre for Health Evaluation and Outcome Sciences, St. Paul\u2019s Hospital, Vancouver, BC V6Z 1Y6, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9170-004X","authenticated-orcid":false,"given":"Levi","family":"Burns","sequence":"additional","affiliation":[{"name":"Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON L8S 4L8, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4532-6197","authenticated-orcid":false,"given":"Robert A.","family":"Olson","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Radiation Oncology and Developmental Radiotherapeutics, University of British Columbia, Vancouver, BC V5Z 1M9, Canada"},{"name":"Department of Radiation Oncology, BC Cancer, Prince George, BC V2M 7E9, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1177\/0840470417715478","article-title":"Provincial development of a patient-reported outcome initiative to guide patient care, quality improvement, and research","volume":"31","author":"Olson","year":"2018","journal-title":"Healthc. Manag. 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Brachytherapy"}],"container-title":["Current Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1718-7729\/29\/7\/376\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:43:44Z","timestamp":1760139824000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1718-7729\/29\/7\/376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,7]]},"references-count":31,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022,7]]}},"alternative-id":["curroncol29070376"],"URL":"https:\/\/doi.org\/10.3390\/curroncol29070376","relation":{},"ISSN":["1718-7729"],"issn-type":[{"type":"electronic","value":"1718-7729"}],"subject":[],"published":{"date-parts":[[2022,7,7]]}}}