{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T18:16:13Z","timestamp":1793470573327,"version":"4.5.0"},"reference-count":20,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T00:00:00Z","timestamp":1657670400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>At present, women with ductal carcinoma in situ are counseled that they have a pre-malignant condition which carries the possibility of progression to a fully malignant breast cancer. However, in most cases, the treatment of DCIS resembles that of a small invasive breast cancer and this is a source of confusion to many. In order to properly evaluate the benefit of radiotherapy, mastectomy and contralateral mastectomy, it is necessary to consider the risks of ipsilateral invasive cancer and of contralateral breast cancer in women with DCIS and with small invasive breast cancer. Several registry-based studies indicate that the risks of ipsilateral and contralateral cancer are similar in the two conditions and therefore a similar approach to treatment is rational.<\/jats:p>","DOI":"10.3390\/curroncol29070392","type":"journal-article","created":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T22:06:00Z","timestamp":1657749960000},"page":"4936-4940","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Countercurrents: DCIS or Cancer? Why All the Confusion?"],"prefix":"10.3390","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5798-0626","authenticated-orcid":false,"given":"Steven A.","family":"Narod","sequence":"first","affiliation":[{"name":"Women\u2019s College Research Institute, Women\u2019s College Hospital, Toronto, ON M5S 1B2, Canada"},{"name":"Institute of Medical Science, University of Toronto, Toronto, ON M5S 1A8, Canada"},{"name":"Dalla Lana School of Public Health, University of Toronto, Toronto, ON M5T 3M7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Sopik","sequence":"additional","affiliation":[{"name":"Women\u2019s College Research Institute, Women\u2019s College Hospital, Toronto, ON M5S 1B2, Canada"},{"name":"Institute of Medical Science, University of Toronto, Toronto, ON M5S 1A8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1002\/cncr.34126","article-title":"\u201cIs it cancer or not?\u201d A qualitative exploration of survivor concerns surrounding the diagnosis and treatment of ductal carcinoma in situ","volume":"128","author":"Rosenberg","year":"2022","journal-title":"Cancer"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"452","DOI":"10.6004\/jnccn.2020.0016","article-title":"Breast Cancer, Version 3.2020, NCCN Clinical Practice Guidelines in Oncology","volume":"18","author":"Gradishar","year":"2020","journal-title":"J. Natl. Compr. Cancer Netw."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.breast.2017.07.012","article-title":"Current trials to reduce surgical intervention in ductal carcinoma in situ of the breast: Critical review","volume":"35","author":"Toss","year":"2017","journal-title":"Breast"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s10549-017-4644-3","article-title":"Is invasion a necessary step for metastases in breast cancer?","volume":"169","author":"Narod","year":"2018","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1001\/jamaoncol.2015.2510","article-title":"Breast Cancer Mortality After a Diagnosis of Ductal Carcinoma In Situ","volume":"1","author":"Narod","year":"2015","journal-title":"JAMA Oncol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Giannakeas, V., Sopik, V., and Narod, S.A. (2018). Association of Radiotherapy With Survival in Women Treated for Ductal Carcinoma In Situ With Lumpectomy or Mastectomy. JAMA Netw. Open, 1.","DOI":"10.1001\/jamanetworkopen.2018.1100"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"m1570","DOI":"10.1136\/bmj.m1570","article-title":"Invasive breast cancer and breast cancer mortality after ductal carcinoma in situ in women attending for breast screening in England, 1988\u20132014: Population based observational cohort study","volume":"369","author":"Mannu","year":"2020","journal-title":"BMJ"},{"key":"ref_8","first-page":"495","article-title":"Risk factors for subsequent invasive breast cancer and breast cancer death after ductal carcinoma in situ: A population-based case-control study in Sweden","volume":"10","author":"Bergh","year":"2001","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1097\/SLA.0000000000002239","article-title":"Cause-specific Mortality in a Population-based Cohort of 9799 Women Treated for Ductal Carcinoma In Situ","volume":"267","author":"Elshof","year":"2018","journal-title":"Ann. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1007\/s10549-011-1531-1","article-title":"Second events following ductal carcinoma in situ of the breast: A register-based cohort study","volume":"129","author":"Falk","year":"2011","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1002\/bjs.10589","article-title":"Risk of death from breast cancer after treatment for ductal carcinoma in situ","volume":"104","author":"Wadsten","year":"2017","journal-title":"Br. J. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s10549-015-3666-y","article-title":"The relationship between local recurrence and death in early-stage breast cancer","volume":"155","author":"Sopik","year":"2016","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1016\/S0140-6736(05)67887-7","article-title":"Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: An overview of the randomised trials","volume":"366","author":"Clarke","year":"2005","journal-title":"Lancet"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/s41416-021-01417-7","article-title":"The risk of contralateral breast cancer: A SEER-based analysis","volume":"125","author":"Giannakeas","year":"2021","journal-title":"Br. J. Cancer"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1056\/NEJMoa022152","article-title":"Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer","volume":"347","author":"Fisher","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1001\/jamaoncol.2017.1261","article-title":"Use of Molecular Tools to Identify Patients With Indolent Breast Cancers With Ultralow Risk Over 2 Decades","volume":"3","author":"Esserman","year":"2017","journal-title":"JAMA Oncol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.breast.2022.03.006","article-title":"Local treatment options for young women with ductal carcinoma in situ: A systematic review and meta-analysis comparing breast conserving surgery with or without adjuvant radiotherapy, and mastectomy","volume":"63","author":"Chien","year":"2022","journal-title":"Breast"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Early Breast Cancer Trialists\u2019 Collaborative Group (EBCTCG), Correa, C., McGale, P., Taylor, C., Wang, Y., Clarke, M., Davies, C., Peto, R., Bijker, N., and Solin, L. (2010). Overview of the randomized trials of radiotherapy in ductal carcinoma in situ of the breast. J. Natl. Cancer Inst. Monogr., 2010, 162\u2013177.","DOI":"10.1093\/jncimonographs\/lgq039"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1007\/s10549-017-4572-2","article-title":"Impact of Microinvasion on Breast Cancer Mortality in Women with Ductal Carcinoma In Situ","volume":"167","author":"Sopik","year":"2018","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s10549-020-05992-w","article-title":"The relationship between the predicted risk of death and psychosocial functioning among women with early-stage breast cancer","volume":"186","author":"Metcalfe","year":"2021","journal-title":"Breast Cancer Res. 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