{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:08:45Z","timestamp":1790208525473,"version":"4.1.0"},"reference-count":24,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T00:00:00Z","timestamp":1662595200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Education","award":["NRF-2021R1I1A1A01055575"],"award-info":[{"award-number":["NRF-2021R1I1A1A01055575"]}]},{"name":"Ministry of Education","award":["ZC21CISI0060"],"award-info":[{"award-number":["ZC21CISI0060"]}]},{"name":"Seoul St. Mary\u2019s Hospital, Catholic University of Korea","award":["NRF-2021R1I1A1A01055575"],"award-info":[{"award-number":["NRF-2021R1I1A1A01055575"]}]},{"name":"Seoul St. Mary\u2019s Hospital, Catholic University of Korea","award":["ZC21CISI0060"],"award-info":[{"award-number":["ZC21CISI0060"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Temporal muscle thickness (TMT) has recently been suggested as a novel biomarker of sarcopenia in head and neck malignancies. However, few studies have evaluated TMT as a prognostic marker in patients with brain metastasis. This study investigated the association of TMT with overall survival (OS) in non-small cell lung cancer (NSCLC) patients with brain metastasis. The records of all NSCLC patients with brain metastasis between 2009 and 2018 at St. Vincent\u2019s Hospital were reviewed retrospectively. A total of 221 patients met our eligibility criteria. In the group with TMT thicker than the median, OS was longer than the group with TMT thinner than the median (240 days versus 139 days, p = 0.014). In multivariate analysis, the thicker TMT group had longer survival (HR 0.73 CI 0.56\u20130.96, p = 0.024). Male (HR 1.58 CI 1.19\u20132.09, p = 0.002) and older age (\u226565 years) (HR 2.05 CI 1.53\u20132.74, p &lt; 0.001) also showed statistical significance. We also performed subgroup analysis in older patients (\u226565 years). In this subgroup of 107 patients, the thicker TMT group also showed longer OS than the thinner TMT group (209 days versus 82 days, p = 0.009). Our findings suggest that TMT can be a useful biomarker for OS in NSCLC patients with brain metastasis.<\/jats:p>","DOI":"10.3390\/curroncol29090508","type":"journal-article","created":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T09:51:09Z","timestamp":1662630669000},"page":"6463-6471","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Association between Temporal Muscle Thickness and Overall Survival in Non-Small Cell Lung Cancer Patients with Brain Metastasis"],"prefix":"10.3390","volume":"29","author":[{"given":"Young Il","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, St. Vincent\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul 16247, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ja Young","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, St. Vincent\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul 16247, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3490-1064","authenticated-orcid":false,"given":"Seung Ho","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, St. Vincent\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul 16247, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1276-713X","authenticated-orcid":false,"given":"Hyun Ho","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Internal Medicine, St. Vincent\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul 16247, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byoung Yong","family":"Shim","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Internal Medicine, St. Vincent\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul 16247, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6854-1597","authenticated-orcid":false,"given":"Stephen","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"381","DOI":"10.3322\/caac.21693","article-title":"Brain and other central nervous system tumor statistics, 2021","volume":"71","author":"Miller","year":"2021","journal-title":"CA Cancer J. 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