{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:33:19Z","timestamp":1783470799831,"version":"3.55.0"},"reference-count":24,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T00:00:00Z","timestamp":1664150400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Key Project of Special Fund for Health Science and Technology Development in Nanjing","award":["ZKX18025"],"award-info":[{"award-number":["ZKX18025"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Head and neck cancer (HNC) sufferers usually encounter arduous nutritional problems when they are receiving antineoplastic therapy. Consequently, the presence of anxiety and depression is commonly observed in this population. This study aimed to explore the physical and psychological influence of nutritional counseling in patients with HNC. Patients receiving concurrent chemo-radiotherapy were randomly assigned to the nutritional counseling group (n = 32, 52.45%) and the control group (n = 29, 47.54%) according to their treatment patterns. In the nutritional counseling group, registered dietitians provided face-to-face counseling during the antineoplastic treatment course at least every two weeks. Nutrient intake amount, relevant nutritional indexes, quality of life, and the degree of anxiety and depression were compared between the two groups. We observed a decrease in the calorie and protein intake amount in both groups, while the decrease in the control group is even worse. The weight loss is more obvious in the control group. The HADS scores in the intervention group were significantly lower than that in the control group (p &lt; 0.05). The Karnofsky Performance Status (KPS) scores in the intervention group were significantly higher than that in the control group (p &lt; 0.05). The level of serum total protein, serum albumin, transferrin, and the thickness of the triceps skin fold decreased less in the intervention group (p &lt; 0.05). Our findings suggest that nutrition counseling is essential for the maintenance of calorie and protein intake in HNC suffers, which contributes to an improvement in the physical and psychological states. The impacts observed in this pilot study warrant further exploration in a larger prospective trial.<\/jats:p>","DOI":"10.3390\/curroncol29100546","type":"journal-article","created":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T05:20:58Z","timestamp":1664169658000},"page":"6947-6955","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Impact of Nutrition Counseling in Head and Neck Cancer Sufferers Undergoing Antineoplastic Therapy: A Randomized Controlled Pilot Study"],"prefix":"10.3390","volume":"29","author":[{"given":"Wangshu","family":"Dai","sequence":"first","affiliation":[{"name":"Department of Geriatric Medcine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-An","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinic Nutrition, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kongcheng","family":"Wang","sequence":"additional","affiliation":[{"name":"The Comprehensive Cancer Center of Drum Tower Hospital, Medical School of Nanjing University, Clinical Cancer Institute of Nanjing University, Nanjing 210008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Clinic Nutrition, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Wang","sequence":"additional","affiliation":[{"name":"The Comprehensive Cancer Center of Drum Tower Hospital, Medical School of Nanjing University, Clinical Cancer Institute of Nanjing University, Nanjing 210008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotian","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Clinic Nutrition, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yan","sequence":"additional","affiliation":[{"name":"The Comprehensive Cancer Center of Drum Tower Hospital, Medical School of Nanjing University, Clinical Cancer Institute of Nanjing University, Nanjing 210008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1056\/NEJMra1715715","article-title":"Head and Neck Cancer","volume":"382","author":"Chow","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.clnu.2016.07.015","article-title":"ESPEN guidelines on nutrition in cancer patients","volume":"36","author":"Arends","year":"2017","journal-title":"Clin. Nutr."},{"key":"ref_4","first-page":"e9","article-title":"Nutrition, anabolism, and the wound healing process: An overview","volume":"9","author":"Demling","year":"2009","journal-title":"Eplasty"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1007\/s00520-020-05804-3","article-title":"Impact of early nutrition counseling in head and neck cancer patients with normal nutritional status","volume":"29","author":"Ho","year":"2021","journal-title":"Supportive Care Cancer"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.clnu.2019.03.030","article-title":"Prevalence and prognostic significance of malnutrition in patients with cancers of the head and neck","volume":"39","author":"Kubrak","year":"2020","journal-title":"Clin. Nutr."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"110548","DOI":"10.1016\/j.nut.2019.06.028","article-title":"Nutrition and swallowing therapy strategies for patients with head and neck cancer","volume":"69","author":"Kristensen","year":"2020","journal-title":"Nutrition"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nutres.2017.08.007","article-title":"Nutrition management for head and neck cancer patients improves clinical outcome and survival","volume":"48","author":"Betz","year":"2017","journal-title":"Nutr. Res."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Neoh, M.K., Abu Zaid, Z., Mat Daud, Z.A., Md Yusop, N.B., Ibrahim, Z., Abdul Rahman, Z., and Jamhuri, N. (2020). Changes in Nutrition Impact Symptoms, Nutritional and Functional Status during Head and Neck Cancer Treatment. Nutrients, 12.","DOI":"10.3390\/nu12051225"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"8075","DOI":"10.7314\/APJCP.2015.16.18.8075","article-title":"Sarcopenia in Cancer Patients","volume":"16","author":"Chindapasirt","year":"2015","journal-title":"Asian Pac. J. Cancer Prev. APJCP"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1002\/hed.25420","article-title":"Association between pretreatment obesity, sarcopenia, and survival in patients with head and neck cancer","volume":"41","author":"Fattouh","year":"2019","journal-title":"Head Neck"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1002\/hed.24760","article-title":"Body mass index and prognosis in patients with head and neck cancer","volume":"39","author":"Gama","year":"2017","journal-title":"Head Neck"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/978-3-319-65421-8_11","article-title":"Nutrition Management for the Head and Neck Cancer Patient","volume":"174","author":"Ackerman","year":"2018","journal-title":"Cancer Treat. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1186\/s12955-020-01543-5","article-title":"Health-related quality of life became worse in short-term during treatment in head and neck cancer patients: A prospective study","volume":"18","author":"Ferreira","year":"2020","journal-title":"Health Qual. 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Diet. J. Dietit. Assoc. Aust."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1080\/01635581.2017.1367943","article-title":"Critical weight loss in patients with oropharynx cancer during radiotherapy (\u00b1 chemotherapy)","volume":"69","author":"Vangelov","year":"2017","journal-title":"Nutr. Cancer"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.ejon.2019.02.004","article-title":"Predictors of weight loss during and after radiotherapy in patients with head and neck cancer: A longitudinal study","volume":"39","author":"Lee","year":"2019","journal-title":"Eur. J. Oncol. Nurs."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1002\/ncp.10476","article-title":"Nutrition Status and Health-Related Quality of Life Among Outpatients with Advanced Head and Neck Cancer","volume":"35","author":"Mulasi","year":"2020","journal-title":"Nutr. Clin. Pract."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.clnesp.2021.05.019","article-title":"Malnutrition screening in head and neck cancer patients with oropharyngeal dysphagia","volume":"44","author":"Simon","year":"2021","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"188","DOI":"10.14740\/jocmr3704","article-title":"Preoperative Depressive Mood of Patients with Esophageal Cancer Might Delay Recovery From Operation-Related Malnutrition","volume":"11","author":"Nakamura","year":"2019","journal-title":"J. Clin. Med. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1001\/archotol.1988.01860240099032","article-title":"Mental depression is associated with malnutrition in patients with head and neck cancer","volume":"114","author":"Westin","year":"1988","journal-title":"Arch. Otolaryngol.\u2014Head Neck Surg."}],"container-title":["Current Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1718-7729\/29\/10\/546\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:39:26Z","timestamp":1760143166000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1718-7729\/29\/10\/546"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,26]]},"references-count":24,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["curroncol29100546"],"URL":"https:\/\/doi.org\/10.3390\/curroncol29100546","relation":{},"ISSN":["1718-7729"],"issn-type":[{"value":"1718-7729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,26]]}}}