{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T16:57:51Z","timestamp":1793206671117,"version":"4.5.0"},"reference-count":122,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T00:00:00Z","timestamp":1664236800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Background: The safe use of radiotherapy (RT) requires compliance with dose\/volume constraints (DVCs) for organs at risk (OaRs). However, the available recommendations are sometimes conflicting and scattered across a number of different documents. Therefore, the aim of this work is to provide, in a single document, practical indications on DVCs for OaRs in external beam RT available in the literature. Material and Methods: A multidisciplinary team collected bibliographic information on the anatomical definition of OaRs, on the imaging methods needed for their definition, and on DVCs in general and in specific settings (curative RT of Hodgkin\u2019s lymphomas, postoperative RT of breast tumors, curative RT of pediatric cancers, stereotactic ablative RT of ventricular arrythmia). The information provided in terms of DVCs was graded based on levels of evidence. Results: Over 650 papers\/documents\/websites were examined. The search results, together with the levels of evidence, are presented in tabular form. Conclusions: A working tool, based on collected guidelines on DVCs in different settings, is provided to help in daily clinical practice of RT departments. This could be a first step for further optimizations.<\/jats:p>","DOI":"10.3390\/curroncol29100552","type":"journal-article","created":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T21:23:27Z","timestamp":1664313807000},"page":"7021-7050","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":84,"title":["Dose\u2013Volume Constraints fOr oRganS At risk In Radiotherapy (CORSAIR): An \u201cAll-in-One\u201d Multicenter\u2013Multidisciplinary Practical Summary"],"prefix":"10.3390","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2358-2499","authenticated-orcid":false,"given":"Silvia","family":"Bisello","sequence":"first","affiliation":[{"name":"Department of Experimental, Diagnostic and Specialty Medicine-DIMES, Alma Mater Studiorum University of Bologna, 40128 Bologna, Italy"},{"name":"Radiation Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40128 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Savino","family":"Cilla","sequence":"additional","affiliation":[{"name":"Medical Physics Unit, Gemelli Molise Hospital-Universit\u00e0 Cattolica del Sacro Cuore, 86100 Campobasso, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Benini","sequence":"additional","affiliation":[{"name":"Department of Experimental, Diagnostic and Specialty Medicine-DIMES, Alma Mater Studiorum University of Bologna, 40128 Bologna, Italy"},{"name":"Radiation Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40128 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Cardano","sequence":"additional","affiliation":[{"name":"Department of Experimental, Diagnostic and Specialty Medicine-DIMES, Alma Mater Studiorum University of Bologna, 40128 Bologna, Italy"},{"name":"Radiation Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40128 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nam P.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Howard University College of Medicine, Washington, DC 20059, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1276-5070","authenticated-orcid":false,"given":"Francesco","family":"Deodato","sequence":"additional","affiliation":[{"name":"Radiation Oncology Unit, Gemelli Molise Hospital-Universit\u00e0 Cattolica del Sacro Cuore, 86100 Campobasso, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0529-201X","authenticated-orcid":false,"given":"Gabriella","family":"Macchia","sequence":"additional","affiliation":[{"name":"Radiation Oncology Unit, Gemelli Molise Hospital-Universit\u00e0 Cattolica del Sacro Cuore, 86100 Campobasso, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milly","family":"Buwenge","sequence":"additional","affiliation":[{"name":"Department of Experimental, Diagnostic and Specialty Medicine-DIMES, Alma Mater Studiorum University of Bologna, 40128 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2111-0164","authenticated-orcid":false,"given":"Silvia","family":"Cammelli","sequence":"additional","affiliation":[{"name":"Department of Experimental, Diagnostic and Specialty Medicine-DIMES, Alma Mater Studiorum University of Bologna, 40128 Bologna, Italy"},{"name":"Radiation Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40128 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tigeneh","family":"Wondemagegnehu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Addis Ababa University, Addis Ababa 1000, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. F. M. Kamal","family":"Uddin","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, United Hospital Limited, Dhaka 1205, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5151-0866","authenticated-orcid":false,"given":"Stefania","family":"Rizzo","sequence":"additional","affiliation":[{"name":"Service of Radiology, Imaging Institute of Southern Switzerland, Ente Ospedaliero Cantonale (EOC), 6500 Lugano, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Bazzocchi","sequence":"additional","affiliation":[{"name":"Diagnostic and Interventional Radiology, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4293-2298","authenticated-orcid":false,"given":"Lidia","family":"Strigari","sequence":"additional","affiliation":[{"name":"Department of Medical Physics, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40128 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9793-3410","authenticated-orcid":false,"given":"Alessio G.","family":"Morganti","sequence":"additional","affiliation":[{"name":"Department of Experimental, Diagnostic and Specialty Medicine-DIMES, Alma Mater Studiorum University of Bologna, 40128 Bologna, Italy"},{"name":"Radiation Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40128 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,27]]},"reference":[{"key":"ref_1","first-page":"767","article-title":"Clinical radiation pathology as applied to curative radiotherapy","volume":"22","author":"Rubin","year":"1968","journal-title":"Front Radiat. Ther. Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0360-3016(91)90171-Y","article-title":"Tolerance of Normal Tissue to Therapeutic Irradiation","volume":"21","author":"Emami","year":"1991","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.ijrobp.2009.08.075","article-title":"Guest Editor\u2019s Introduction to QUANTEC: A Users Guide","volume":"76","author":"Marks","year":"2010","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.ijrobp.2009.09.040","article-title":"Quantitative Analyses of Normal Tissue Effects in the Clinic (QUANTEC): An Introduction to the Scientific Issues","volume":"76","author":"Bentzen","year":"2010","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1016\/j.ijrobp.2009.07.1754","article-title":"Use of Normal Tissue Complication Probability Models in the Clinic","volume":"76","author":"Marks","year":"2010","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.clon.2022.02.010","article-title":"UK 2022 Consensus on Normal Tissue Dose-Volume Constraints for Oligometastatic, Primary Lung and Hepatocellular Carcinoma Stereotactic Ablative Radiotherapy","volume":"34","author":"Diez","year":"2022","journal-title":"Clin. Oncol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.clon.2017.09.007","article-title":"UK Consensus on Normal Tissue Dose Constraints for Stereotactic Radiotherapy","volume":"30","author":"Hanna","year":"2018","journal-title":"Clin. Oncol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"4078","DOI":"10.1118\/1.3438081","article-title":"Stereotactic Body Radiation Therapy: The Report of AAPM Task Group 101","volume":"37","author":"Benedict","year":"2010","journal-title":"Med. Phys."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ijrobp.2020.08.013","article-title":"Single- and Multifraction Stereotactic Radiosurgery Dose\/Volume Tolerances of the Brain","volume":"110","author":"Milano","year":"2021","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1120\/jacmp.v12i2.3368","article-title":"Dose Tolerance Limits and Dose Volume Histogram Evaluation for Stereotactic Body Radiotherapy","volume":"12","author":"Grimm","year":"2011","journal-title":"J. Appl. Clin. Med. Phys."},{"key":"ref_11","unstructured":"(2022, September 16). NCCN Clinical Practice Guidelines in Oncology-Hodgkin Lymphoma. Version 1.2023. Available online: https:\/\/www.nccn.org\/guidelines\/guidelines-detail?category=1&id=1439."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/S0140-6736(17)31145-5","article-title":"Partial-Breast Radiotherapy after Breast Conservation Surgery for Patients with Early Breast Cancer (UK IMPORT LOW Trial): 5-Year Results from a Multicentre, Randomised, Controlled, Phase 3, Non-Inferiority Trial","volume":"390","author":"Coles","year":"2017","journal-title":"Lancet"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"4175","DOI":"10.1200\/JCO.20.00650","article-title":"Accelerated Partial-Breast Irradiation Compared with Whole-Breast Irradiation for Early Breast Cancer: Long-Term Results of the Randomized Phase III APBI-IMRT-Florence Trial","volume":"38","author":"Meattini","year":"2020","journal-title":"J. Clin. Oncol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1016\/S0140-6736(20)30932-6","article-title":"Hypofractionated Breast Radiotherapy for 1 Week versus 3 Weeks (FAST-Forward): 5-Year Efficacy and Late Normal Tissue Effects Results from a Multicentre, Non-Inferiority, Randomised, Phase 3 Trial","volume":"395","author":"Haviland","year":"2020","journal-title":"Lancet"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e28349","DOI":"10.1002\/pbc.28349","article-title":"Late Effects of Radiation Therapy in Pediatric Patients and Survivorship","volume":"68","author":"Palmer","year":"2021","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_16","unstructured":"Milano, M.T., Vargo, J.A., Yorke, E.D., Ronckers, C.M., Kremer, L.C., Chafe, S.M.J., van Santen, H.M., Marks, L.B., Bentzen, S.M., and Constine, L.S. (2021). Primary Hypothyroidism in Childhood Cancer Survivors Treated With Radiation Therapy: A PENTEC Comprehensive Review. Int. J. Radiat. Oncol., S0360-3016(21)00128-0."},{"key":"ref_17","unstructured":"Mahajan, A., Stavinoha, P.L., Rongthong, W., Brodin, N.P., McGovern, S.L., El Naqa, I., Palmer, J.D., Vennarini, S., Indelicato, D.J., and Aridgides, P. (2021). Neurocognitive Effects and Necrosis in Childhood Cancer Survivors Treated With Radiation Therapy: A PENTEC Comprehensive Review. Int. J. Radiat. Oncol. Biol. Phys., S0360-3016(21)00127-9."},{"key":"ref_18","unstructured":"Milgrom, S.A., van Luijk, P., Pino, R., Ronckers, C.M., Kremer, L.C., Gidley, P.W., Grosshans, D.R., Laskar, S., Okcu, M.F., and Constine, L.S. (2021). Salivary and Dental Complications in Childhood Cancer Survivors Treated With Radiation Therapy to the Head and Neck: A Pediatric Normal Tissue Effects in the Clinic (PENTEC) Comprehensive Review. Int. J. Radiat. Oncol. Biol. Phys., S0360-3016(21)00443-0."},{"key":"ref_19","unstructured":"Lo, A.C., Ronckers, C., Aznar, M.C., Avanzo, M., van Dijk, I., Kremer, L.C.M., Gagliardi, G., Howell, R.M., Rancati, T., and Constine, L.S. (2021). Breast Hypoplasia and Decreased Lactation From Radiation Therapy in Survivors of Pediatric Malignancy: A PENTEC Comprehensive Review. Int. J. Radiat. Oncol. Biol. Phys., S0360-3016(21)02725-5."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.prro.2014.05.003","article-title":"Implementation of Contemporary Radiation Therapy Planning Concepts for Pediatric Hodgkin Lymphoma: Guidelines from the International Lymphoma Radiation Oncology Group","volume":"5","author":"Hodgson","year":"2015","journal-title":"Pract. Radiat. Oncol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/acm2.13454","article-title":"SBRT of Ventricular Tachycardia Using 4pi Optimized Trajectories","volume":"22","author":"Reis","year":"2021","journal-title":"J. Appl. Clin. Med. Phys."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1007\/s00392-020-01650-9","article-title":"Radiosurgery for Ventricular Tachycardia: Preclinical and Clinical Evidence and Study Design for a German Multi-Center Multi-Platform Feasibility Trial (RAVENTA)","volume":"109","author":"Blanck","year":"2020","journal-title":"Clin. Res. Cardiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.cjco.2020.11.006","article-title":"Review of Stereotactic Arrhythmia Radioablation Therapy for Cardiac Tachydysrhythmias","volume":"3","author":"Chiu","year":"2021","journal-title":"CJC Open"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"858","DOI":"10.5152\/AnatolJCardiol.2021.187","article-title":"Stereotactic Ablative Body Radiotherapy for Ventricular Tachycardia: An Alternative Therapy for Refractory Patients","volume":"25","author":"Besse","year":"2021","journal-title":"Anatol. J. Cardiol."},{"key":"ref_25","unstructured":"(2022, July 31). NCCN Clinical Practice Guidelines in Oncology\u2014Non-Small Cell Lung Cancer. Version 5.2022. Available online: https:\/\/www.nccn.org\/guidelines\/guidelines-detail?category=1&id=1450."},{"key":"ref_26","unstructured":"(2022, September 07). NCCN Clinical Practice Guidelines in Oncology\u2014Esophageal and Esophagogastric Junction Cancers. Version 4.2022. Available online: https:\/\/www.nccn.org\/guidelines\/guidelines-detail?category=1&id=1433."},{"key":"ref_27","unstructured":"(2022, January 11). NCCN Clinical Practice Guidelines in Oncology\u2014Gastric Gancer. Version 2.2022. Available online: https:\/\/www.nccn.org\/guidelines\/guidelines-detail?category=1&id=1434."},{"key":"ref_28","unstructured":"(2022, September 02). NCCN Clinical Practice Guidelines in Oncology\u2014Anal Cancer. Version 2.2022. Available online: https:\/\/www.nccn.org\/guidelines\/guidelines-detail?category=1&id=1414."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.radonc.2020.05.038","article-title":"Organ at Risk Delineation for Radiation Therapy Clinical Trials: Global Harmonization Group Consensus Guidelines: GHG OAR Consensus Contouring Guidance","volume":"150","author":"Mir","year":"2020","journal-title":"Radiother. Oncol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1186\/s13014-018-1187-7","article-title":"Impact of VMAT-IMRT Compared to 3D Conformal Radiotherapy on Anal Sphincter Dose Distribution in Neoadjuvant Chemoradiation of Rectal Cancer","volume":"13","author":"Dapper","year":"2018","journal-title":"Radiat. Oncol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13014-019-1262-8","article-title":"A Systematic Review of Dose-Volume Predictors and Constraints for Late Bowel Toxicity Following Pelvic Radiotherapy","volume":"14","author":"Jadon","year":"2019","journal-title":"Radiat. Oncol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13014-019-1374-1","article-title":"Dose-Volume Analysis of Predictors for Acute Anal Toxicity after Radiotherapy in Prostate Cancer Patients","volume":"14","author":"Peng","year":"2019","journal-title":"Radiat. Oncol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1001\/jamaoncol.2020.6332","article-title":"Association of Left Anterior Descending Coronary Artery Radiation Dose with Major Adverse Cardiac Events and Mortality in Patients with Non-Small Cell Lung Cancer","volume":"7","author":"Atkins","year":"2021","journal-title":"JAMA Oncol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.oraloncology.2018.08.018","article-title":"Revisiting the Dose Constraints for Head and Neck OARs in the Current Era of IMRT","volume":"86","author":"Brodin","year":"2018","journal-title":"Oral Oncol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1186\/s13014-014-0264-9","article-title":"Technical Guidelines for Head and Neck Cancer IMRT on Behalf of the Italian Association of Radiation Oncology\u2014Head and Neck Working Group","volume":"9","author":"Merlotti","year":"2014","journal-title":"Radiat. Oncol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.radonc.2020.07.052","article-title":"ESTRO ACROP Guidelines for Target Volume Definition in Pancreatic Cancer","volume":"154","author":"Brunner","year":"2021","journal-title":"Radiother. Oncol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.radonc.2017.12.013","article-title":"The EPTN Consensus-Based Atlas for CT- and MR-Based Contouring in Neuro-Oncology","volume":"128","author":"Eekers","year":"2018","journal-title":"Radiother. Oncol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1093\/jrr\/rrt006","article-title":"Three-Fraction CyberKnife Radiotherapy for Brain Metastases in Critical Areas: Referring to the Risk Evaluating Radiation Necrosis and the Surrounding Brain Volumes Circumscribed with a Single Dose Equivalence of 14 Gy (V14)","volume":"54","author":"Inoue","year":"2013","journal-title":"J. Radiat. Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.radonc.2015.12.003","article-title":"ESTRO-ACROP Guideline \u201cTarget Delineation of Glioblastomas\u201d","volume":"118","author":"Niyazi","year":"2016","journal-title":"Radiother. Oncol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.radonc.2015.01.016","article-title":"Organs at Risk in the Brain and Their Dose-Constraints in Adults and in Children: A Radiation Oncologist\u2019s Guide for Delineation in Everyday Practice","volume":"114","author":"Scoccianti","year":"2015","journal-title":"Radiother. Oncol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1748-717X-4-52","article-title":"Clinical-Dosimetric Analysis of Measures of Dysphagia Including Gastrostomy-Tube Dependence among Head and Neck Cancer Patients Treated Definitively by Intensity-Modulated Radiotherapy with Concurrent Chemotherapy","volume":"4","author":"Li","year":"2009","journal-title":"Radiat. Oncol."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Basu, T., and Bhaskar, N. (2019). Overview of Important \u201cOrgans at Risk\u201d (OAR) in Modern Radiotherapy for Head and Neck Cancer (HNC). Cancer Survivorship, IntechOpen.","DOI":"10.5772\/intechopen.80606"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.radonc.2018.05.001","article-title":"Radiation Dose Constraints for Organs at Risk in Neuro-Oncology; the European Particle Therapy Network Consensus","volume":"128","author":"Lambrecht","year":"2018","journal-title":"Radiother. Oncol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.ijrobp.2012.11.031","article-title":"Hippocampal Dosimetry Predicts Neurocognitive Function Impairment after Fractionated Stereotactic Radiotherapy for Benign or Low-Grade Adult Brain Tumors","volume":"85","author":"Gondi","year":"2013","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1200\/JCO.19.02767","article-title":"Hippocampal Avoidance during Whole-Brain Radiotherapy plus Memantine for Patients with Brain Metastases: Phase III Trial NRG Oncology CC001","volume":"38","author":"Brown","year":"2020","journal-title":"J. Clin. Oncol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jocn.2013.04.005","article-title":"Hippocampal-Sparing Radiotherapy: The New Standard of Care for World Health Organization Grade II and III Gliomas?","volume":"21","author":"Pinkham","year":"2014","journal-title":"J. Clin. Neurosci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.ijrobp.2012.01.022","article-title":"Radiation Therapy Oncology Group Consensus Panel Guidelines for the Delineation of the Clinical Target Volume in the Postoperative Treatment of Pancreatic Head Cancer","volume":"83","author":"Goodman","year":"2012","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1080\/0284186X.2017.1400690","article-title":"Pudendal Nerve Injury Impairs Anorectal Function and Health Related Quality of Life Measures \u22652 Years after 3D Conformal Radiotherapy for Prostate Cancer","volume":"57","author":"Yeoh","year":"2018","journal-title":"Acta Oncol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2796925","DOI":"10.1155\/2017\/2796925","article-title":"Ovary-Sparing Radiation Planning Techniques Can Achieve Ovarian Dose Reduction for Soft Tissue Sarcoma of the Buttock and Thigh","volume":"2017","author":"Kovtun","year":"2017","journal-title":"Sarcoma"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"10","DOI":"10.14338\/IJPT-D-19-00061.1","article-title":"Preserving Endocrine Function in Premenopausal Women Undergoing Whole Pelvis Radiation for Cervical Cancer","volume":"6","author":"Vyfhuis","year":"2019","journal-title":"Int. J. Part. Ther."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1002\/cam4.924","article-title":"The Relationship between Ovarian Function and Ovarian Limited Dose in Radiotherapy Postoperation of Ovarian Transposition in Young Patients with Cervical Cancer","volume":"6","author":"Du","year":"2017","journal-title":"Cancer Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.radonc.2020.07.009","article-title":"The Analysis of Absorbed Dose by Pancreas during Gastric Cancer Radiotherapy","volume":"151","author":"Polanowski","year":"2020","journal-title":"Radiother. Oncol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1186\/s13014-018-1189-5","article-title":"Volumetric Decrease of Pancreas after Abdominal Irradiation, It Is Time to Consider Pancreas as an Organ at Risk for Radiotherapy Planning 11 Medical and Health Sciences 1103 Clinical Sciences","volume":"13","author":"Gemici","year":"2018","journal-title":"Radiat. Oncol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1007\/s11102-022-01219-x","article-title":"Endocrine Disorders after Primary Gamma Knife Radiosurgery for Pituitary Adenomas: A Systematic Review and Meta-Analysis","volume":"25","author":"Palmisciano","year":"2022","journal-title":"Pituitary"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s13014-017-0824-x","article-title":"Radiation-Related Lymphopenia Is Associated with Spleen Irradiation Dose during Radiotherapy in Patients with Hepatocellular Carcinoma","volume":"12","author":"Liu","year":"2017","journal-title":"Radiat. Oncol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.ijrobp.2016.10.046","article-title":"Does Unintentional Splenic Radiation Predict Outcomes After Pancreatic Cancer Radiation Therapy?","volume":"97","author":"Chadha","year":"2017","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Zschaeck, S., Bl\u00fcmke, B., Wust, P., Kaul, D., Bahra, M., Riess, H., Klein, F., Sinn, M., Pelzer, U., and Budach, V. (2017). Dose-Escalated Radiotherapy for Unresectable or Locally Recurrent Pancreatic Cancer: Dose Volume Analysis, Toxicity and Outcome of 28 Consecutive Patients. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0186341"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1186\/s13014-021-01959-3","article-title":"Feasibility Study of Volumetric Modulated Arc Therapy with HalcyonTM Linac for Total Body Irradiation","volume":"16","author":"Uehara","year":"2021","journal-title":"Radiat. Oncol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/andr.12562","article-title":"Radiation Effects on Male Fertility","volume":"7","author":"Marchetti","year":"2019","journal-title":"Andrology"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.radonc.2013.05.002","article-title":"GEC\/ESTRO Recommendations on High Dose Rate Afterloading Brachytherapy for Localised Prostate Cancer: An Update","volume":"107","author":"Hoskin","year":"2013","journal-title":"Radiother. Oncol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.radonc.2021.12.047","article-title":"GEC-ESTRO ACROP Prostate Brachytherapy Guidelines","volume":"167","author":"Henry","year":"2022","journal-title":"Radiother. Oncol."},{"key":"ref_62","unstructured":"Susan, S.G. (2020). Anatomy the Anatomical Basis of Clinical Practice, Elsevier."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ijrobp.2009.10.058","article-title":"Development and Validation of a Heart Atlas to Study Cardiac Exposure to Radiation Following Treatment for Breast Cancer","volume":"79","author":"Feng","year":"2011","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.radonc.2017.01.008","article-title":"A Cardiac Contouring Atlas for Radiotherapy","volume":"122","author":"Duane","year":"2017","journal-title":"Radiother. Oncol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1097\/00006534-200206000-00052","article-title":"Anatomical Structure of the Buccal Fat Pad and Its Clinical Adaptations","volume":"109","author":"Zhang","year":"2002","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"e353","DOI":"10.1016\/j.ijrobp.2012.01.023","article-title":"Pelvic Normal Tissue Contouring Guidelines for Radiation Therapy: A Radiation Therapy Oncology Group Consensus Panel Atlas","volume":"83","author":"Gay","year":"2012","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.radonc.2015.07.041","article-title":"CT-Based Delineation of Organs at Risk in the Head and Neck Region: DAHANCA, EORTC, GORTEC, HKNPCSG, NCIC CTG, NCRI, NRG Oncology and TROG Consensus Guidelines","volume":"117","author":"Brouwer","year":"2015","journal-title":"Radiother. Oncol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1016\/j.ijrobp.2006.03.018","article-title":"Dosimetric Predictors of Acute Hematologic Toxicity in Cervical Cancer Patients Treated with Concurrent Cisplatin and Intensity-Modulated Pelvic Radiotherapy","volume":"66","author":"Mell","year":"2006","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.prro.2013.06.004","article-title":"Upper Abdominal Normal Organ Contouring Guidelines and Atlas: A Radiation Therapy Oncology Group Consensus","volume":"4","author":"Jabbour","year":"2014","journal-title":"Pract. Radiat. Oncol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.radonc.2015.12.027","article-title":"ESTRO Consensus Guideline on Target Volume Delineation for Elective Radiation Therapy of Early Stage Breast Cancer, Version 1.1","volume":"118","author":"Offersen","year":"2016","journal-title":"Radiother. Oncol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.ijrobp.2021.08.023","article-title":"Thecal Sac Contouring as a Surrogate for the Cauda Equina and Intracanal Spinal Nerve Roots for Spine Stereotactic Body Radiation Therapy (SBRT): Contour Variability and Recommendations for Safe Practice","volume":"112","author":"Dunne","year":"2022","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.ijrobp.2011.11.074","article-title":"Development of a Standardized Method for Contouring the Lumbosacral Plexus: A Preliminary Dosimetric Analysis of This Organ at Risk among 15 Patients Treated with Intensity-Modulated Radiotherapy for Lower Gastrointestinal Cancers and the Incidence of Rad","volume":"84","author":"Yi","year":"2012","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1016\/j.ijrobp.2010.07.1977","article-title":"Consideration of Dose Limits for Organs at Risk of Thoracic Radiotherapy: Atlas for Lung, Proximal Bronchial Tree, Esophagus, Spinal Cord, Ribs, and Brachial Plexus","volume":"81","author":"Kong","year":"2011","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.radonc.2020.06.015","article-title":"Delineation of Whole Heart and Substructures in Thoracic Radiation Therapy: National Guidelines and Contouring Atlas by the Danish Multidisciplinary Cancer Groups","volume":"150","author":"Milo","year":"2020","journal-title":"Radiother. Oncol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.radonc.2011.05.015","article-title":"Delineation of Organs at Risk Involved in Swallowing for Radiotherapy Treatment Planning","volume":"101","author":"Christianen","year":"2011","journal-title":"Radiother. Oncol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1016\/j.ijrobp.2011.12.058","article-title":"Australasian Gastrointestinal Trials Group (AGITG) Contouring Atlas and Planning Guidelines for Intensity-Modulated Radiotherapy in Anal Cancer","volume":"83","author":"Ng","year":"2012","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Ferini, G., Valenti, V., Puliafito, I., Illari, S.I., Marchese, V.A., and Borz\u00ec, G.R. (2021). Volumetric Modulated Arc Therapy Capabilities for Treating Lower-Extremity Skin Affected by Several Merkel Cell Carcinoma Nodules: When Technological Advances Effectively Achieve the Palliative Therapeutic Goal While Minimising the Risk of Potential Toxicities. Medicina, 57.","DOI":"10.3390\/medicina57121379"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"a031922","DOI":"10.1101\/cshperspect.a031922","article-title":"The Heart and Great Vessels","volume":"8","author":"Ekene","year":"2018","journal-title":"Cold Spring Harb Perspect Med."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1097\/COC.0b013e318178e4e8","article-title":"A Radiation Oncologist\u2019s Guide to Contouring the Hippocampus","volume":"32","author":"Chera","year":"2009","journal-title":"Am. J. Clin. Oncol. Cancer Clin. Trials"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1118\/1.597259","article-title":"Management of Radiation Oncology Patients with Implanted Cardiac Pacemakers: Report of AAPM Task Group No. 34","volume":"21","author":"Wolbarst","year":"1994","journal-title":"Med. Phys."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.radonc.2021.05.013","article-title":"Update of the EPTN Atlas for CT- and MR-Based Contouring in Neuro-Oncology","volume":"160","author":"Eekers","year":"2021","journal-title":"Radiother. Oncol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1080\/02841850600885419","article-title":"Magnetic Resonance Imaging of the Ovaries of Healthy Women: Determination of Normal Values","volume":"47","author":"Hauth","year":"2006","journal-title":"Acta radiol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1148\/radiographics.12.3.1609137","article-title":"MR Imaging of the Female Pelvic Region","volume":"12","author":"Olson","year":"1992","journal-title":"Radiographics"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"e14","DOI":"10.1148\/rg.e14","article-title":"Cross-Sectional and Functional Imaging of the Temporomandibular Joint: Radiology, Pathology, and Basic Biomechanics of the Jaw","volume":"23","author":"Sommer","year":"2003","journal-title":"RadioGraphics"},{"key":"ref_85","unstructured":"Baggish, M.S., and Mickey, K.M. (2006). Atlas of Pelvic Anatomy and Gynecologic Surgery, Saunder. [2nd ed.]."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.ijrobp.2006.03.012","article-title":"Fatal Pneumonitis Associated with Intensity-Modulated Radiation Therapy for Mesothelioma","volume":"65","author":"Allen","year":"2006","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Rancati, T., and Fiorino, C. (2019). Modelling Radiotherapy Side Effects, CRC Press.","DOI":"10.1201\/b21956"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1002\/mp.14913","article-title":"The HyTEC Project","volume":"48","author":"Grimm","year":"2021","journal-title":"Med. Phys."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijrobp.2020.10.039","article-title":"High Dose per Fraction, Hypofractionated Treatment Effects in the Clinic (HyTEC): An Overview","volume":"110","author":"Grimm","year":"2021","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.21873\/invivo.12390","article-title":"A Ten-Year-Long Update on Radiation Proctitis among Prostate Cancer Patients Treated with Curative External Beam Radiotherapy","volume":"35","author":"Ferini","year":"2021","journal-title":"Vivo"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.21873\/anticanres.14981","article-title":"How Much Daily Image-Guided Volumetric Modulated Arc Therapy Is Useful for Proctitis Prevention with Respect to Static Intensity Modulated Radiotherapy Supported by Topical Medications among Localized Prostate Cancer Patients?","volume":"41","author":"Ferini","year":"2021","journal-title":"Anticancer Res."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"446","DOI":"10.3390\/gastroent12040043","article-title":"Radiation Proctitis: The Potential Role of Hyaluronic Acid in the Prevention and Restoration of Any Damage to the Rectal Mucosa among Prostate Cancer Patients Submitted to Curative External Beam Radiotherapy","volume":"12","author":"Ferini","year":"2021","journal-title":"Gastroenterol. Insights"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.ejmp.2014.01.002","article-title":"Clinical Implications of Different Calculation Algorithms in Breast Radiotherapy: A Comparison between Pencil Beam and Collapsed Cone Convolution","volume":"30","author":"Cilla","year":"2014","journal-title":"Phys. Medica"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.ijrobp.2010.10.018","article-title":"A Phase i Dose Escalation Study of Hypofractionated IMRT Field-in-Field Boost for Newly Diagnosed Glioblastoma Multiforme","volume":"82","author":"Monjazeb","year":"2012","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"626400","DOI":"10.3389\/fonc.2020.626400","article-title":"Post-Operative Accelerated-Hypofractionated Chemoradiation With Volumetric Modulated Arc Therapy and Simultaneous Integrated Boost in Glioblastoma: A Phase I Study (ISIDE-BT-2)","volume":"10","author":"Ferro","year":"2021","journal-title":"Front. Oncol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1007\/s12094-016-1552-7","article-title":"Stereotactic Body Radiotherapy in Non-Operable Lung Cancer Patients","volume":"18","author":"Santacaterina","year":"2016","journal-title":"Clin. Transl. Oncol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1007\/s11547-021-01441-w","article-title":"A Non-Surgical COMBO-Therapy Approach for Locally Advanced Unresectable Pancreatic Adenocarcinoma: Preliminary Results of a Prospective Study","volume":"127","author":"Parisi","year":"2022","journal-title":"Radiol. Medica"},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Ferini, G., Parisi, S., Lillo, S., Viola, A., Minutoli, F., Critelli, P., Valenti, V., Illari, S.I., Brogna, A., and Umana, G.E. (2022). Impressive Results after \u201c Metabolism-Guided \u201d Lattice Irradiation in Patients Submitted to Palliative Radiation Therapy: Preliminary Results of LATTICE_01 Multicenter Study. Cancers, 14.","DOI":"10.3390\/cancers14163909"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1080\/0284186X.2017.1366049","article-title":"The NARLAL2 Dose Escalation Trial: Dosimetric Implications of Inter-Fractional Changes in Organs at Risk","volume":"57","author":"Hoffmann","year":"2018","journal-title":"Acta Oncol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00066-022-01974-7","article-title":"Intensity-Modulated Radiotherapy Does Not Induce Volumetric Changes of the Bichat Fat Pad in Nasopharyngeal Cancer","volume":"198","author":"Cacciola","year":"2022","journal-title":"Strahlenther. Und Onkol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"92904","DOI":"10.18632\/oncotarget.21646","article-title":"Association between Dose-Volume Parameters and Acute Bone Marrow Suppression in Rectal Cancer Patients Treated with Concurrent Chemoradiotherapy","volume":"8","author":"Li","year":"2017","journal-title":"Oncotarget"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.ijrobp.2011.12.072","article-title":"Normal Tissue Complication Probability Modeling of Acute Hematologic Toxicity in Patients Treated with Intensity-Modulated Radiation Therapy for Squamous Cell Carcinoma of the Anal Canal","volume":"84","author":"Bazan","year":"2012","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1002\/cncr.24949","article-title":"Prediction of Pathologic Fracture Risk of the Femur after Combined Modality Treatment of Soft Tissue Sarcoma of the Thigh","volume":"116","author":"Gortzak","year":"2010","journal-title":"Cancer"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"315","DOI":"10.2106\/00004623-200502000-00012","article-title":"Fractures Following Radiotherapy and Limb-Salvage Surgery for Lower Extremity Soft-Tissue Sarcomas: A Comparison of High-Dose and Low-Dose Radiotherapy","volume":"87","author":"Holt","year":"2005","journal-title":"J. Bone Jt. Surg."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/S0360-3016(00)01387-0","article-title":"Hypothalamic\/Pituitary Function Following High-Dose Conformal Radiotherapy to the Base of Skull: Demonstration of a Dose-Effect Relationship Using Dose-Volume Histogram Analysis","volume":"49","author":"Pai","year":"2001","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1748-717X-9-31","article-title":"Vaginal Tolerance of CT Based Image-Guided High-Dose Rate Interstitial Brachytherapy for Gynecological Malignancies","volume":"9","author":"Murakami","year":"2014","journal-title":"Radiat. Oncol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.radonc.2015.12.025","article-title":"Dose-Effect Relationship and Risk Factors for Vaginal Stenosis after Definitive Radio(Chemo)Therapy with Image-Guided Brachytherapy for Locally Advanced Cervical Cancer in the EMBRACE Study","volume":"118","author":"Kirchheiner","year":"2016","journal-title":"Radiother. Oncol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.ijrobp.2020.03.019","article-title":"Involved Site Radiation Therapy in Adult Lymphomas: An Overview of International Lymphoma Radiation Oncology Group Guidelines","volume":"107","author":"Wirth","year":"2020","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.21873\/anticanres.14912","article-title":"Anatomical Predictors of Dosimetric Advantages for Deep-Inspiration-Breath-Hold 3D-Conformal Radiotherapy among Women with Left Breast Cancer","volume":"41","author":"Ferini","year":"2021","journal-title":"Anticancer Res."},{"key":"ref_110","first-page":"118","article-title":"Dose Constraints for Whole Breast Radiation Therapy Based on the Quality Assessment of Treatment Plans in the Randomised Danish Breast Cancer Group (DBCG) HYPO Trial","volume":"28","author":"Thomsen","year":"2021","journal-title":"Clin. Transl. Radiat. Oncol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"233","DOI":"10.4329\/wjr.v3.i9.233","article-title":"Assessment of Contralateral Mammary Gland Dose in the Treatment of Breast Cancer Using Accelerated Hypofractionated Radiotherapy","volume":"3","author":"Tolia","year":"2011","journal-title":"World J. Radiol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1120\/jacmp.v15i2.4547","article-title":"Effect of RTOG Breast\/Chest Wall Guidelines on Dose-Volume Histogram Parameters","volume":"15","author":"Rudra","year":"2014","journal-title":"J. Appl. Clin. Med. Phys."},{"key":"ref_113","first-page":"59","article-title":"Organs at Risk Radiation Dose Constraints","volume":"26","author":"Antoni","year":"2022","journal-title":"Cancer"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/s13014-016-0701-z","article-title":"Phase II Trial of Hypofractionated VMAT-Based Treatment for Early Stage Breast Cancer: 2-Year Toxicity and Clinical Results","volume":"11","author":"Fogliata","year":"2016","journal-title":"Radiat. Oncol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"437","DOI":"10.2147\/BCTT.S130090","article-title":"An Effective Deep-Inspiration Breath-Hold Radiotherapy Technique for Left-Breast Cancer: Impact of Post-Mastectomy Treatment, Nodal Coverage, and Dose Schedule on Organs at Risk","volume":"9","author":"Rice","year":"2017","journal-title":"Breast Cancer Targets Ther."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.ijrobp.2017.11.026","article-title":"Brainstem Injury in Pediatric Patients With Posterior Fossa Tumors Treated With Proton Beam Therapy and Associated Dosimetric Factors","volume":"100","author":"Gentile","year":"2018","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.radonc.2021.08.012","article-title":"Radiation Therapy Related Cardiac Disease Risk in Childhood Cancer Survivors: Updated Dosimetry Analysis from the Childhood Cancer Survivor Study","volume":"163","author":"Shrestha","year":"2021","journal-title":"Radiother. Oncol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.prro.2019.10.002","article-title":"Dose-Effect Analysis of Early Changes in Orbital Bone Morphology After Radiation Therapy for Rhabdomyosarcoma","volume":"10","author":"Hol","year":"2020","journal-title":"Pr. Radiat Oncol"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejca.2020.10.025","article-title":"The Spleen as an Organ at Risk in Paediatric Radiotherapy: A SIOP-Europe Radiation Oncology Working Group Report","volume":"143","author":"Arunagiri","year":"2021","journal-title":"Eur. J. 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