{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T12:10:34Z","timestamp":1783080634997,"version":"3.54.6"},"reference-count":12,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T00:00:00Z","timestamp":1665360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"King Fahad Medical City","award":["021-11"],"award-info":[{"award-number":["021-11"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>The clinical behaviors, prognosis, and appropriate treatments of papillary tumors of the pineal region (PTPR) are not fully defined due to the rarity of these tumors. At diagnosis, PTPR may present with clinical symptoms, including headache with obstructive hydrocephalus, diplopia, vomiting, and lethargy, as well as neurological signs, including Argyll Robertson pupils and Parinaud\u2019s syndrome due to compression of the dorsal midbrain, specifically the periaqueductal region with horizontal nystagmus. Radiological assessment of pineal region lesions is challenging, with a wide range of potential differential diagnoses. PTPR typically presents as a heterogeneous, well-circumscribed mass in the pineal region, which might contain cystic areas, calcifications, hemorrhages, or protein accumulations. Here, we report three female pediatric patients with PTPR treated in King Fahad Medical City (KFMC) in Saudi Arabia. Histological and immunohistochemical diagnosis was confirmed by analysis of genome-wide DNA methylation profiles. This case series expands on the available reports on the clinical presentations of PTPR and provides important information on the responses to different treatment modalities.<\/jats:p>","DOI":"10.3390\/curroncol29100595","type":"journal-article","created":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T21:07:11Z","timestamp":1665436031000},"page":"7558-7568","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Papillary Tumor of the Pineal Region Rare Pediatric CNS Tumor Case Series Treated in King Fahad Medical City (KFMC)"],"prefix":"10.3390","volume":"29","author":[{"given":"Nahla A.","family":"Mobark","sequence":"first","affiliation":[{"name":"Department of Pediatric Oncology Comprehensive Cancer Centre, King Fahad Medical City, Riyadh 12231, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Musa","family":"Alharbi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology Comprehensive Cancer Centre, King Fahad Medical City, Riyadh 12231, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahad","family":"Alotabi","sequence":"additional","affiliation":[{"name":"Pediatric Neurosurgical Department, King Fahad Medical City, Riyadh 12231, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azhar","family":"Alshoumer","sequence":"additional","affiliation":[{"name":"Department of Pathology & Laboratory Medicine, King Fahad Medical City, Riyadh 12231, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wafa","family":"Al Shakweer","sequence":"additional","affiliation":[{"name":"Department of Pathology & Laboratory Medicine, King Fahad Medical City, Riyadh 12231, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaid G.","family":"AlNaqib","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology Comprehensive Cancer Centre, King Fahad Medical City, Riyadh 12231, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulaziz N.","family":"AlSaad","sequence":"additional","affiliation":[{"name":"Radiology Department, King Fahad Medical City, Riyadh 12231, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali O.","family":"Balbaid","sequence":"additional","affiliation":[{"name":"Radiation Oncology Department, Comprehensive Cancer Centre, King Fahad Medical City, Riyadh 12231, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebtehal","family":"Alsolme","sequence":"additional","affiliation":[{"name":"Genomics Research Department, King Fahad Medical City, Riyadh 12231, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malak S.","family":"Abedalthagafi","sequence":"additional","affiliation":[{"name":"Genomics Research Department, King Fahad Medical City, Riyadh 12231, Saudi Arabia"},{"name":"Department of Pathology & Laboratory Medicine, Emory University, Atlanta, GA 30322, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s00401-007-0243-4","article-title":"The 2007 WHO Classification of Tumours of the Central Nervous System","volume":"114","author":"Louis","year":"2007","journal-title":"Acta Neuropathol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1093\/neuonc\/noab106","article-title":"The 2021 WHO Classification of Tumors of the Central Nervous System: A summary","volume":"23","author":"Louis","year":"2021","journal-title":"Neuro-Oncology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"106404","DOI":"10.1016\/j.clineuro.2020.106404","article-title":"Papillary tumor of the pineal region in pediatric populations: An additional case and systematic review of a rare tumor entity","volume":"201","author":"Mathkour","year":"2021","journal-title":"Clin. 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Pathol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"v37","DOI":"10.1093\/neuonc\/nov204.88","article-title":"ATPS-88 Temozolomide and Everolimus in the Treatment of Papillary Tumor of the Pineal Region","volume":"17","author":"West","year":"2015","journal-title":"Neuro-Oncology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1093\/neuonc\/noy153","article-title":"Durable response to mTOR inhibition in a patient with relapsing papillary tumor of the pineal region","volume":"21","author":"Belting","year":"2019","journal-title":"Neuro-Oncology"}],"container-title":["Current Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1718-7729\/29\/10\/595\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:49:32Z","timestamp":1760143772000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1718-7729\/29\/10\/595"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,10]]},"references-count":12,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["curroncol29100595"],"URL":"https:\/\/doi.org\/10.3390\/curroncol29100595","relation":{},"ISSN":["1718-7729"],"issn-type":[{"value":"1718-7729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,10]]}}}