{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T16:26:40Z","timestamp":1777912000735,"version":"3.51.4"},"reference-count":81,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T00:00:00Z","timestamp":1665619200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["82173210"],"award-info":[{"award-number":["82173210"]}]},{"name":"National Natural Science Foundation of China","award":["H2021206176"],"award-info":[{"award-number":["H2021206176"]}]},{"name":"Hebei Natural Science Foundation","award":["82173210"],"award-info":[{"award-number":["82173210"]}]},{"name":"Hebei Natural Science Foundation","award":["H2021206176"],"award-info":[{"award-number":["H2021206176"]}]},{"name":"outstanding medical talents project","award":["82173210"],"award-info":[{"award-number":["82173210"]}]},{"name":"outstanding medical talents project","award":["H2021206176"],"award-info":[{"award-number":["H2021206176"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>The main features of a giant cell tumor of bone (GCTB) are frequent recurrence and aggressive osteolysis, which leads to a poor prognosis in patients. Although the treatment methods for a GCTB, such as scraping and resection, effectively inhibit the disease, the tendency toward malignant transformation remains. Therefore, it is important to identify new treatment methods for a GCTB. In this study, we first found high Siglec-15 expression in GCTB tissues, which was significantly associated with Campanacci staging and tumor recurrence. In Spearman\u2019s analysis, Siglec-15 expression was significantly correlated with Ki-67 levels in tumor tissues. In vitro, the mRNA and protein levels of Siglec-15 were high in GCTB stromal cells (Hs737. T), and Siglec-15 knockdown inhibited the biological characteristics of GCTB stromal cells. The RNA sequencing results enabled a prediction of the downstream genes by using the Kyoto Encyclopedia of Genes and Genomes (KEGG), Gene Ontology (GO), and MCODE analyses, and the findings showed that CXCL8 was significantly regulated by Siglec-15 and might be a promising downstream target gene of Siglec-15. Therefore, Siglec-15 may be a potential immunotherapy target for a GCTB.<\/jats:p>","DOI":"10.3390\/curroncol29100605","type":"journal-article","created":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T20:55:11Z","timestamp":1665694511000},"page":"7655-7671","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Siglec-15 as a New Perspective Therapy Target in Human Giant Cell Tumor of Bone"],"prefix":"10.3390","volume":"29","author":[{"given":"Mengke","family":"Fan","sequence":"first","affiliation":[{"name":"Department of Orthopedic Research Center, Third Hospital of Hebei Medical University, Shijiazhuang 050051, China"},{"name":"Department of Orthopedic Oncology, Third Hospital of Hebei Medical University, Shijiazhuang 050051, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guochuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Oncology, Third Hospital of Hebei Medical University, Shijiazhuang 050051, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingfang","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Oncology, Third Hospital of Hebei Medical University, Shijiazhuang 050051, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinbo","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Fourth Hospital of Hebei Medical University, Shijiazhuang 050010, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Research Center, Third Hospital of Hebei Medical University, Shijiazhuang 050051, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2463-5487","authenticated-orcid":false,"given":"Ling","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Research Center, Third Hospital of Hebei Medical University, Shijiazhuang 050051, China"},{"name":"Department of Orthopedic Oncology, Third Hospital of Hebei Medical University, Shijiazhuang 050051, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/os.12375","article-title":"Recurrence of Giant Cell Tumor of the Spine after Resection: A Report of 10 Cases","volume":"10","author":"Lin","year":"2018","journal-title":"Orthop. 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