{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T03:18:14Z","timestamp":1774927094274,"version":"3.50.1"},"reference-count":30,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T00:00:00Z","timestamp":1669680000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) is a treatment option for peritoneal metastases (PM) but is associated with significant postoperative morbidity. The aim of this study was to determine the prognostic value of computed tomographic (CT)-measured sarcopenia on postoperative outcomes and survival in patients undergoing CRS-HIPEC for PM from various origins. A retrospective cohort study was conducted between 2012 and 2020. Three-hundred and twelve patients (mean age 57.6 \u00b1 10.3, 34.3% male) were included, of which 88 (28.2%) were sarcopenic. PM from a colorectal origin was the most common in both groups. The proportion of major postoperative complications (Clavien-Dindo \u2265 III) was not higher in the sarcopenic group (15.9% in sarcopenic patients vs. 23.2% in nonsarcopenic patients, p = 0.17). The mean Comprehensive Complication Index scores, HIPEC-related toxicities, length of hospital stay, and duration of parenteral nutrition were comparable regardless of sarcopenia status. In the multivariate logistic regression analysis of severe complications, only peritoneal carcinomatosis index reached statistical significance (OR, 1.05; 95% CI, 1.01 to 1.08, p = 0.007). Sarcopenia did not impact origin-specific overall survival on Cox regression analysis. Sarcopenia was not associated with worse rates of postoperative severe complications or worse survival rates. Future prospective studies are required before considering sarcopenia as part of preoperative risk assessment.<\/jats:p>","DOI":"10.3390\/curroncol29120730","type":"journal-article","created":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T02:09:58Z","timestamp":1669687798000},"page":"9314-9324","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Impact of Computed Tomography Measurements of Sarcopenia on Postoperative and Oncologic Outcomes in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy"],"prefix":"10.3390","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2678-4857","authenticated-orcid":false,"given":"Maher","family":"Al Khaldi","sequence":"first","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery, H\u00f4pital Maisonneuve-Rosemont, CIUSS de l\u2019Est de l\u2019\u00efle de Montr\u00e9al, Montr\u00e9al, QC H1T 2M4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massine","family":"Fellouah","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery, H\u00f4pital Maisonneuve-Rosemont, CIUSS de l\u2019Est de l\u2019\u00efle de Montr\u00e9al, Montr\u00e9al, QC H1T 2M4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Drolet","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, H\u00f4pital Maisonneuve-Rosemont, CIUSSS de l\u2019Est de l\u2019\u00cele de Montr\u00e9al, Montr\u00e9al, QC H1T 2M4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien","family":"C\u00f4t\u00e9","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery, H\u00f4pital Maisonneuve-Rosemont, CIUSS de l\u2019Est de l\u2019\u00efle de Montr\u00e9al, Montr\u00e9al, QC H1T 2M4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2403-462X","authenticated-orcid":false,"given":"Bertrand","family":"Trilling","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery, H\u00f4pital Maisonneuve-Rosemont, CIUSS de l\u2019Est de l\u2019\u00efle de Montr\u00e9al, Montr\u00e9al, QC H1T 2M4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9607-6987","authenticated-orcid":false,"given":"Alexandre","family":"Brind\u2019Amour","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery, H\u00f4pital Maisonneuve-Rosemont, CIUSS de l\u2019Est de l\u2019\u00efle de Montr\u00e9al, Montr\u00e9al, QC H1T 2M4, Canada"},{"name":"Division of Surgical Oncology, Department of Surgery, CHU de Qu\u00e9bec-Universit\u00e9 Laval, Qu\u00e9bec, QC G1R 2J6, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Dugas","sequence":"additional","affiliation":[{"name":"Division Abdominal Radiology, Department of Radiology, Maisonneuve-Rosemont, CIUSSS de l\u2019Est de l\u2019\u00cele de Montr\u00e9al, Montr\u00e9al, QC H1T 2M4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Fran\u00e7ois","family":"Tremblay","sequence":"additional","affiliation":[{"name":"Division of Colorectal Surgery, Department of Surgery, H\u00f4pital Maisonneuve-Rosemont, CIUSSS de l\u2019Est de l\u2019\u00cele de Montr\u00e9al, Montr\u00e9al, QC H1T 2M4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne","family":"Fortin","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology, Department of Surgery, H\u00f4pital Maisonneuve-Rosemont, CIUSSS de l\u2019Est de l\u2019\u00cele de Montr\u00e9al, Montr\u00e9al, QC H1T 2M4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lara","family":"De Guerk\u00e9","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology, Department of Surgery, H\u00f4pital Maisonneuve-Rosemont, CIUSSS de l\u2019Est de l\u2019\u00cele de Montr\u00e9al, Montr\u00e9al, QC H1T 2M4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-H\u00e9l\u00e8ne","family":"Auclair","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology, Department of Surgery, H\u00f4pital Maisonneuve-Rosemont, CIUSSS de l\u2019Est de l\u2019\u00cele de Montr\u00e9al, Montr\u00e9al, QC H1T 2M4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Dub\u00e9","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery, H\u00f4pital Maisonneuve-Rosemont, CIUSS de l\u2019Est de l\u2019\u00efle de Montr\u00e9al, Montr\u00e9al, QC H1T 2M4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4576-5774","authenticated-orcid":false,"given":"Mika\u00ebl","family":"Soucisse","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery, H\u00f4pital Maisonneuve-Rosemont, CIUSS de l\u2019Est de l\u2019\u00efle de Montr\u00e9al, Montr\u00e9al, QC H1T 2M4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9326-4392","authenticated-orcid":false,"given":"Lucas","family":"Sideris","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery, H\u00f4pital Maisonneuve-Rosemont, CIUSS de l\u2019Est de l\u2019\u00efle de Montr\u00e9al, Montr\u00e9al, QC H1T 2M4, 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