{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:15:44Z","timestamp":1771460144862,"version":"3.50.1"},"reference-count":30,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T00:00:00Z","timestamp":1669766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Background: The aim of this study was to investigate the feasibility of ultrahypofractionated radiotherapy to the prostate bed in patients with biochemical and\/or clinical relapse following radical prostatectomy who were enrolled in the prospective, observational, multicentric POPART trial (NCT04831970). Methods: Patients with post-radical prostatectomy PSA levels of \u22650.1\u20132.0 ng\/mL and\/or local relapse at PSMA PET\/CT or multiparametric MRI were treated with Linac-based SBRT on the prostate bed up to a total dose of 32.5 Gy in five fractions every other day (EQD21.5 = 74.2 Gy). Maximum acute toxicity was assessed using the Common Terminology Criteria for Adverse Events version 5 scale. International Consultation on Incontinence Questionnaire\u2014Short Form (ICIQ-SF) and Prostate Cancer Index Composite for Clinical Practice (EPIC-CP) scores were assessed at baseline and during the follow-up. Results: From April 2021 to June 2022, thirty men with a median age of 72 years (range 55\u201382) were enrolled in three centers. The median PSA level before RT was 0.30 ng\/mL (range 0.18\u20131.89 ng\/mL). At 3 months post-treatment, no GI or \u22652 GU side effects were reported; three patients (10%) experienced Grade 1 GU toxicity. No changes in ICIQ-SF or in the urinary domains of EPIC-CP were observed, while a transient worsening was registered in the bowel domain. At the same time point, all but two patients, who progressed distantly, were found to be biochemically controlled with a median post-treatment PSA level of 0.07 ng\/mL (range 0\u20130.48 ng\/mL). Conclusions: Our preliminary findings show that SBRT can be safely extended to the postoperative setting, without an increase in short-term toxicity or a significant decline in QoL. Long-term results are needed to confirm this strategy.<\/jats:p>","DOI":"10.3390\/curroncol29120733","type":"journal-article","created":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T08:46:41Z","timestamp":1669798001000},"page":"9349-9356","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Acute Toxicity and Quality of Life in a Post-Prostatectomy Ablative Radiation Therapy (POPART) Multicentric Trial"],"prefix":"10.3390","volume":"29","author":[{"given":"Raffaella","family":"Lucchini","sequence":"first","affiliation":[{"name":"School of Medicine and Surgery, University of Milan Bicocca, 20126 Milan, Italy"},{"name":"Department of Radiation Oncology, ASST Monza, 20900 Monza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6893-6284","authenticated-orcid":false,"given":"Ciro","family":"Franzese","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4Pieve Emanuele, 20090 Milan, Italy"},{"name":"Department of Radiotherapy and Radiosurgery, Humanitas Clinical and Research Center\u2014IRCCS, Rozzano, 20089 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suela","family":"Vukcaj","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, ASST Papa Giovanni XXIII, 24127 Bergamo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2457-5613","authenticated-orcid":false,"given":"Giorgio","family":"Purrello","sequence":"additional","affiliation":[{"name":"School of Medicine and Surgery, University of Milan Bicocca, 20126 Milan, Italy"},{"name":"Department of Radiation Oncology, ASST Monza, 20900 Monza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8309-924X","authenticated-orcid":false,"given":"Denis","family":"Panizza","sequence":"additional","affiliation":[{"name":"School of Medicine and Surgery, University of Milan Bicocca, 20126 Milan, Italy"},{"name":"Department of Medical Physics, ASST Monza, 20900 Monza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Faccenda","sequence":"additional","affiliation":[{"name":"Department of Medical Physics, ASST Monza, 20900 Monza, Italy"},{"name":"Department of Physics, University of Milan, 20122 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4105-9493","authenticated-orcid":false,"given":"Stefano","family":"Andreoli","sequence":"additional","affiliation":[{"name":"Department of Medical Physics, ASST Papa Giovanni XXIII, 24127 Bergamo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2144-6485","authenticated-orcid":false,"given":"Gian Luca","family":"Poli","sequence":"additional","affiliation":[{"name":"Department of Medical Physics, ASST Papa Giovanni XXIII, 24127 Bergamo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Baldaccini","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy and Radiosurgery, Humanitas Clinical and Research Center\u2014IRCCS, Rozzano, 20089 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Lo Faro","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4Pieve Emanuele, 20090 Milan, Italy"},{"name":"Department of Radiotherapy and Radiosurgery, Humanitas Clinical and Research Center\u2014IRCCS, Rozzano, 20089 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Tomatis","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy and Radiosurgery, Humanitas Clinical and Research Center\u2014IRCCS, Rozzano, 20089 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi Franco","family":"Cazzaniga","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, ASST Papa Giovanni XXIII, 24127 Bergamo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Scorsetti","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4Pieve Emanuele, 20090 Milan, Italy"},{"name":"Department of Radiotherapy and Radiosurgery, Humanitas Clinical and Research Center\u2014IRCCS, Rozzano, 20089 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3880-8876","authenticated-orcid":false,"given":"Stefano","family":"Arcangeli","sequence":"additional","affiliation":[{"name":"School of Medicine and Surgery, University of Milan Bicocca, 20126 Milan, Italy"},{"name":"Department of Radiation Oncology, ASST Monza, 20900 Monza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.eururo.2021.05.033","article-title":"Dose-intensified Versus Conventional-dose Salvage Radiotherapy for Biochemically Recurrent Prostate Cancer After Prostatectomy: The SAKK 09\/10 Randomized Phase 3 Trial","volume":"80","author":"Ghadjar","year":"2021","journal-title":"Eur. 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