{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T07:23:56Z","timestamp":1789802636982,"version":"4.0.1"},"reference-count":61,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T00:00:00Z","timestamp":1670457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"AstraZeneca","award":["ES2020-1939"],"award-info":[{"award-number":["ES2020-1939"]}]},{"name":"AstraZeneca","award":["FSEOM2018"],"award-info":[{"award-number":["FSEOM2018"]}]},{"name":"Spanish Society of Medical Oncology Foundation","award":["ES2020-1939"],"award-info":[{"award-number":["ES2020-1939"]}]},{"name":"Spanish Society of Medical Oncology Foundation","award":["FSEOM2018"],"award-info":[{"award-number":["FSEOM2018"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>A cancer diagnosis can have a substantial impact on a patient\u2019s mental health and quality of life. The aim of this study was to investigate the prevalence of fatigue, emotional distress, and uncertainty and examine the predictive value they have on the quality of life of advanced cancer patients. A prospective, multicenter study was conducted between February 2020 and May 2021 of individuals diagnosed with an advanced, unresectable neoplasm prior to initiating systemic antineoplastic treatment. Participants completed questionnaires to quantify fatigue, emotional distress, disease uncertainty, and quality of life. A linear regression analysis was performed to study the predictive QoL variables. The study population comprised 508 patients, 53.7% of whom were male and had a mean age of 54.9 years. The most common cancers were digestive (40.6%), bronchopulmonary (29.1%), and breast (8.5%); the most frequent histology was adenocarcinoma (63%); and most were stage IV (79.7%). More than half (55.7%) suffered fatigue, and 47.7% exhibited emotional distress; both were more prevalent among women. Fatigue, emotional distress, and disease uncertainty all correlate with diminished quality of life. Similarly, ECOG performance status and the demographic variables of age, sex, and comorbidities impacted quality of life. This patient sample displayed a high prevalence of fatigue and emotional distress, together with illness uncertainty, which are clearly linked to waning quality of life. To decrease the experience of fatigue and improve mental health treatment in cancer patients, interventions based on a biopsychosocial model must be intensified.<\/jats:p>","DOI":"10.3390\/curroncol29120763","type":"journal-article","created":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T03:59:46Z","timestamp":1670558386000},"page":"9722-9732","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":77,"title":["Fatigue, Emotional Distress, and Illness Uncertainty in Patients with Metastatic Cancer: Results from the Prospective NEOETIC_SEOM Study"],"prefix":"10.3390","volume":"29","author":[{"given":"Adan","family":"Rodriguez-Gonzalez","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Hospital Universitario Central de Asturias, ISPA, 33011 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Velasco-Durantez","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Hospital Universitario Central de Asturias, ISPA, 33011 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5747-9652","authenticated-orcid":false,"given":"Carla","family":"Martin-Abreu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Hospital Universitario de Canarias, 38320 Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Cruz-Castellanos","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Hospital Universitario La Paz, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Hospital Universitario de Canarias, 38320 Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireia","family":"Gil-Raga","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Hospital General Universitario de Valencia, CIBERONC, 46014 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3744-2182","authenticated-orcid":false,"given":"Esmeralda","family":"Garcia-Torralba","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Hospital General Universitario Morales Messenger de Murcia, 30008 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0110-8016","authenticated-orcid":false,"given":"Teresa","family":"Garcia-Garcia","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Hospital Universitario Santa Lucia, 30202 Cartagena, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Jimenez-Fonseca","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Hospital Universitario Central de Asturias, ISPA, 33011 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6956-9321","authenticated-orcid":false,"given":"Caterina","family":"Calderon","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology and Psychobiology, Faculty of Psychology, University of Barcelona, 08007 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,8]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (WHO) (2017). 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