{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:44:02Z","timestamp":1760147042838,"version":"build-2065373602"},"reference-count":28,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T00:00:00Z","timestamp":1672963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian Ministry of Health\u2014Ricerca Corrente Annual Program 2023"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Mantle cell lymphoma is a B-cell malignancy, which, in its classic form, usually involves lymph nodes and extranodal sites, and, among the extranodal sites, the gastrointestinal tract and the Waldeyer\u2019s ring are most prevalent. MCL is rarely reported in the ocular adnexa, a site more frequently affected by extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue, which is a form of low-grade malignancy. The diagnosis of MCL presenting in the ocular adnexa requires special attention as its rarity in this location combined with the not uncommon CD5 negativity of the disease when occurring in the ocular adnexa, may lead the pathologist to overlook the diagnosis and misinterpret MCL as marginal zone B cell lymphoma, which has a totally different behavior. Herein, we present a case of primary bilateral conjunctival CD5-negative MCL in a patient having no other sites affected by lymphoma and we discuss possible diagnostic pitfalls.<\/jats:p>","DOI":"10.3390\/curroncol30010062","type":"journal-article","created":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T07:28:10Z","timestamp":1673249290000},"page":"824-831","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["CD5-Negative Primary Mantle Cell Lymphoma Presenting with a Bilateral Conjunctival Mass: A Potential Diagnostic Pitfall"],"prefix":"10.3390","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8733-9933","authenticated-orcid":false,"given":"Magda","family":"Zanelli","sequence":"first","affiliation":[{"name":"Pathology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Lugli","sequence":"additional","affiliation":[{"name":"Department of Pathological Anatomy, Modena University Hospital, 41125 Modena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2299-5160","authenticated-orcid":false,"given":"Andrea","family":"Palicelli","sequence":"additional","affiliation":[{"name":"Pathology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Sanguedolce","sequence":"additional","affiliation":[{"name":"Pathology Unit, Policlinico Riuniti, University of Foggia, 71122 Foggia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9841-7856","authenticated-orcid":false,"given":"Maurizio","family":"Zizzo","sequence":"additional","affiliation":[{"name":"Surgical Oncology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9844-4763","authenticated-orcid":false,"given":"Camilla","family":"Cresta","sequence":"additional","affiliation":[{"name":"Pathology Unit, Azienda Ospedaliera Santa Maria di Terni, University of Perugia, 05100 Terni, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuele","family":"Biancafarina","sequence":"additional","affiliation":[{"name":"Pathology Unit, Azienda Ospedaliera Santa Maria di Terni, University of Perugia, 05100 Terni, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Martino","sequence":"additional","affiliation":[{"name":"Pathology Unit, Azienda Ospedaliera Santa Maria di Terni, University of Perugia, 05100 Terni, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Crescenzi","sequence":"additional","affiliation":[{"name":"Haematology Unit, CREO, Azienda Ospedaliera di Perugia, University of Perugia, 06129 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5582-6131","authenticated-orcid":false,"given":"Saverio","family":"Pancetti","sequence":"additional","affiliation":[{"name":"Pathology Unit, Humanitas University, Pieve Emanuele, 20072 Milan, Italy"},{"name":"Pathology Unit, Humanitas Research Hospital-IRCCS, Rozzano, 20089 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2576-6523","authenticated-orcid":false,"given":"Giuseppe","family":"Broggi","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences and Advanced Technologies \u201cG.F. Ingrassia\u201d Anatomic Pathology, University of Catania, 95123 Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8591-8010","authenticated-orcid":false,"given":"Rosario","family":"Caltabiano","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences and Advanced Technologies \u201cG.F. Ingrassia\u201d Anatomic Pathology, University of Catania, 95123 Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7956-9950","authenticated-orcid":false,"given":"Luca","family":"Cimino","sequence":"additional","affiliation":[{"name":"Ocular Immunology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy"},{"name":"Department of Surgery, Medicine, Dentistry and Morphological Sciences, University of Modena and Reggio Emilia, 41124 Modena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Mecucci","sequence":"additional","affiliation":[{"name":"Haematology Unit, CREO, Azienda Ospedaliera di Perugia, University of Perugia, 06129 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Ascani","sequence":"additional","affiliation":[{"name":"Pathology Unit, Azienda Ospedaliera Santa Maria di Terni, University of Perugia, 05100 Terni, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/0277-5379(89)90416-1","article-title":"Primary extranodal and nodal non-Hodgkin\u2019s lymphoma. A survey of a population-based registry","volume":"25","author":"Otter","year":"1989","journal-title":"Eur. J. Cancer Clin. Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/0046-8177(90)90181-4","article-title":"Lymphoid hyperplasia and malignant lymphoma occurring in the ocular adnexa (orbit, conjunctiva, and eyelids): A prospective multiparametric analysis of 108 cases during 1977\u20131987","volume":"21","author":"Knowles","year":"1990","journal-title":"Hum. Pathol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1002\/1097-0142(19940501)73:9<2395::AID-CNCR2820730924>3.0.CO;2-V","article-title":"Orbital and adnexal involvement in systemic non-Hodgkin\u2019s lymphoma","volume":"73","author":"Bairey","year":"1994","journal-title":"Cancer"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.1365-2559.1993.tb00489.x","article-title":"Primary low-grade B-cell lymphoma of the conjunctiva: A mucosa-associated lymphoid tissue type lymphoma","volume":"23","author":"Wotherspoon","year":"1993","journal-title":"Histopathology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1111\/joim.12684","article-title":"The aetiology of B-cell lymphoid malignancies with a focus on chronic inflammation and infections","volume":"282","author":"Smedby","year":"2017","journal-title":"J. Intern. Med."},{"key":"ref_6","unstructured":"WHO Classification of Tumours Editorial Board (2017). WHO Classification of Tumours Haematopoietic and Lymphoid Tissues, IARC. [Revised 4th ed.]."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1182\/blood-2018-03-791392","article-title":"Update on mantle cell lymphoma","volume":"132","author":"Maddocks","year":"2018","journal-title":"Blood"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/HS9.0000000000000302","article-title":"Mantle cell lymphoma of mucosa-associated lymphoid tissue: A European mantle cell lymphoma network study","volume":"4","author":"Morello","year":"2020","journal-title":"Hemasphere"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.ophtha.2004.07.025","article-title":"Mantle cell lymphoma in the ocular adnexal region","volume":"112","author":"Looi","year":"2005","journal-title":"Ophthalmology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1007\/s00428-006-0268-4","article-title":"Primary mantle cell lymphoma of the conjunctiva: A case report","volume":"449","author":"Aspiotis","year":"2006","journal-title":"Virchows Arch."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.prp.2008.04.009","article-title":"CD5-undetected by immunohistochemistry, t(11;14)(q13;q32)-positive conjunctival mantle cell lymphoma: A case report","volume":"204","author":"Yoo","year":"2008","journal-title":"Pathol. Res. Pract."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1136\/bjo.2008.146910","article-title":"Mantle cell lymphoma in the orbital and adnexal region","volume":"93","author":"Rasmussen","year":"2009","journal-title":"Br. J. Ophthalmol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Khanlari, M., Bagheri, B., Vojdani, R., Mohammadianpanath, M., Paydar, S., and Daneshbod, Y. (2012). Conjunctival mass as an initial presentation of mantle cell lymphoma: A case report. BMC Res. Notes, 5.","DOI":"10.1186\/1756-0500-5-671"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s12288-014-0389-x","article-title":"Ocular adnexal lymphomas: Report of 2 cases of mantle cell lymphomas and short review of the literature","volume":"30","author":"Sahu","year":"2014","journal-title":"Indian J. Hematol. Blood Transf."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.survophthal.2016.05.005","article-title":"Bilateral ocular paraadnexal mass as initial presentation of systemic blastoid variant of mantle-cell lymphoma","volume":"62","author":"Rasic","year":"2017","journal-title":"Surv. Ophthalmol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jcjo.2017.09.005","article-title":"mantle cell lymphoma: Conjunctival mass in a female patient","volume":"53","author":"Zhang","year":"2018","journal-title":"Can. J. Ophthalmol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/aos.15248","article-title":"Ocular adnexal lymphoma: Subtype-specific clinical and genetic features","volume":"100","author":"Kirkegaard","year":"2022","journal-title":"Acta Ophthalmol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"6908","DOI":"10.3390\/curroncol29100543","article-title":"Primary vitreoretinal lymphoma: Current diagnostic laboratory tests and new emerging molecular tools","volume":"29","author":"Melli","year":"2022","journal-title":"Curr. Oncol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1182\/blood-2012-08-452284","article-title":"CCND2 rearrangements are the most frequent genetic events in cyclin D1(-) mantle cell lymphoma","volume":"121","author":"Salaverria","year":"2013","journal-title":"Blood"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ajo.2018.11.002","article-title":"Orbital lymphoma. An international multicenter retrospective study","volume":"199","author":"Olsen","year":"2019","journal-title":"Am. J. Ophthalmol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ajo.2020.06.015","article-title":"Lymphoma of the lacrimal gland. An international multicenter retrospective study","volume":"219","author":"Vest","year":"2020","journal-title":"Am. J. Ophthalmol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1136\/bjo.84.8.907","article-title":"Histological features of ocular adnexal lymphoma (REAL classification) and their association with patient morbidity and survival","volume":"84","author":"Jenkins","year":"2000","journal-title":"Br. J. Ophthalmol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.humpath.2006.10.017","article-title":"Cyclin D1 and t(11;14)-positive B-cell neoplasms resembling marginal zone B-cell lymphoma: A morphological variant of mantle cell lymphoma","volume":"38","author":"Mansoor","year":"2007","journal-title":"Hum. Pathol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1634\/theoncologist.2012-0425","article-title":"A reapparisal of the diagnostic and therapeutic management of uncommon histologies of primary ocular adnexal lymphoma","volume":"18","author":"Ponzoni","year":"2013","journal-title":"Oncologist"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"106840","DOI":"10.1016\/j.leukres.2022.106840","article-title":"CD5-positive marginal zone lymphoma: Clinicopathological features and survival outcomes","volume":"117","author":"Xia","year":"2022","journal-title":"Leuk. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1097\/PAS.0000000000001278","article-title":"CD5-negative mantle cell lymphoma: Clinicopathologic correlations and outcome in 58 patients","volume":"43","author":"Miao","year":"2019","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1097\/01.pas.0000213350.49767.46","article-title":"Lymphoma of the ocular adnexa: A study of 353 cases","volume":"31","author":"Ferry","year":"2007","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1002\/ajh.26523","article-title":"Mantle cell lymphoma in 2022-A comprehensive update on molecular pathogenesis, risk stratification, clinical approach and current and novel treatments","volume":"97","author":"Jain","year":"2022","journal-title":"Am. J. Hematol."}],"container-title":["Current Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1718-7729\/30\/1\/62\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:02:18Z","timestamp":1760119338000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1718-7729\/30\/1\/62"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,6]]},"references-count":28,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["curroncol30010062"],"URL":"https:\/\/doi.org\/10.3390\/curroncol30010062","relation":{},"ISSN":["1718-7729"],"issn-type":[{"type":"electronic","value":"1718-7729"}],"subject":[],"published":{"date-parts":[[2023,1,6]]}}}