{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:02:19Z","timestamp":1787961739962,"version":"build-2784847793"},"reference-count":35,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T00:00:00Z","timestamp":1673308800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>The aim of the present study was to evaluate the incidence of concomitant vulvar cancers or premalignant lesions in women surgically treated for extramammary Paget\u2019s disease of the vulva (EMPDV) through a multicenter case series. The medical records of all women diagnosed with and treated for EMPDV from January 2010 to December 2020 were retrospectively analyzed. Women with EMPDV and synchronous vulvar cancer, vulvar intraepithelial neoplasia (VIN) and\/or lichen sclerosus (LS) at the histology report were included in the study. A total of 69 women eligible for the present study were considered. Concomitant vulvar lesions occurred in 22 cases (31.9%). A total of 11 cases of synchronous VIN (50%) and 14 cases (63.6%) of concomitant LS were observed. One patient (4.5%) had synchronous vulvar SCC (FIGO stage 1B). Women with EMPDV and concomitant premalignant\/malignant vulvar lesions had a significantly higher rate of invasive EMPDV and wider lesions with an extravulvar involvement. The specific meaning of the association between EMPDV, VIN, SCC and LS remains unclear. The potential overlapping features between different vulvar lesions highlight the importance of dedicated gynecologists and pathologists in referral centers.<\/jats:p>","DOI":"10.3390\/curroncol30010073","type":"journal-article","created":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T02:27:12Z","timestamp":1673317632000},"page":"959-966","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Extramammary Paget\u2019s Disease of the Vulva and Concomitant Premalignant\/Malignant Vulvar Lesions: A Potential Challenge in Diagnosis and Treatment"],"prefix":"10.3390","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2748-3041","authenticated-orcid":false,"given":"Nicol\u00f2","family":"Clemente","sequence":"first","affiliation":[{"name":"Gynecological Oncology Unit, Centro di Riferimento Oncologico\u2014National Cancer Institute, IRCCS, 33081 Aviano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8037-4947","authenticated-orcid":false,"given":"Andrea","family":"Ciavattini","sequence":"additional","affiliation":[{"name":"Gynecologic Section, Department of Odontostomatologic and Specialized Clinical Sciences, Universit\u00e0 Politecnica delle Marche, 60123 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4756-587X","authenticated-orcid":false,"given":"Gaetano","family":"Valenti","sequence":"additional","affiliation":[{"name":"Gynecological Oncology Unit, Centro di Riferimento Oncologico\u2014National Cancer Institute, IRCCS, 33081 Aviano, Italy"},{"name":"Unit of Gynecology and Obstetrics, Department of Women\u2019s and Children\u2019s Health, Umberto I Hospital, 94100 Enna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Zannier","sequence":"additional","affiliation":[{"name":"Pathology Unit, Centro di Riferimento Oncologico\u2014National Cancer Institute, IRCCS, 33081 Aviano, Italy"},{"name":"Pathology Unit, Santa Maria della Misericordia University Hospital, 33100 Udine, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6162-6299","authenticated-orcid":false,"given":"Jacopo","family":"Di Giuseppe","sequence":"additional","affiliation":[{"name":"Gynecologic Section, Department of Odontostomatologic and Specialized Clinical Sciences, Universit\u00e0 Politecnica delle Marche, 60123 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Delli Carpini","sequence":"additional","affiliation":[{"name":"Gynecologic Section, Department of Odontostomatologic and Specialized Clinical Sciences, Universit\u00e0 Politecnica delle Marche, 60123 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1929-6270","authenticated-orcid":false,"given":"Mariasole","family":"Fichera","sequence":"additional","affiliation":[{"name":"Gynecological Oncology Unit, Centro di Riferimento Oncologico\u2014National Cancer Institute, IRCCS, 33081 Aviano, Italy"},{"name":"Gynecologic Section, Department of Odontostomatologic and Specialized Clinical Sciences, Universit\u00e0 Politecnica delle Marche, 60123 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Del Fabro","sequence":"additional","affiliation":[{"name":"Gynecological Oncology Unit, Centro di Riferimento Oncologico\u2014National Cancer Institute, IRCCS, 33081 Aviano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Giorda","sequence":"additional","affiliation":[{"name":"Gynecological Oncology Unit, Centro di Riferimento Oncologico\u2014National Cancer Institute, IRCCS, 33081 Aviano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5198-8387","authenticated-orcid":false,"given":"Gaia","family":"Goteri","sequence":"additional","affiliation":[{"name":"Division of Pathological Anatomy, Department of Biomedical Sciences and Public Health, Universit\u00e0 Politecnica delle Marche, 60123 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6010-0976","authenticated-orcid":false,"given":"Vincenzo","family":"Canzonieri","sequence":"additional","affiliation":[{"name":"Pathology Unit, Centro di Riferimento Oncologico\u2014National Cancer Institute, IRCCS, 33081 Aviano, Italy"},{"name":"Department of Medical, Surgical, and Health Sciences, University of Trieste, 34127 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Sopracordevole","sequence":"additional","affiliation":[{"name":"Gynecological Oncology Unit, Centro di Riferimento Oncologico\u2014National Cancer Institute, IRCCS, 33081 Aviano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1097\/LGT.0000000000000191","article-title":"Surgical Treatment of Paget Disease of the Vulva: Prognostic Significance of Stromal Invasion and Surgical Margin Status","volume":"20","author":"Sopracordevole","year":"2016","journal-title":"J. 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