{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:45:30Z","timestamp":1760147130447,"version":"build-2065373602"},"reference-count":36,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T00:00:00Z","timestamp":1673568000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>(1) Background: cervical cancer is one of the leading causes of cancer-related deaths and the fourth most common cancer among women worldwide. Magnetic resonance imaging (MRI) is the modality of choice for loco-regional staging of cervical cancer in the primary diagnostic workup beginning with at least stage IB. (2) Methods: we retrospectively analyzed 16 patients with histopathological proven cervical cancer (FIGO IB1\u2013IVA) for the diagnostic accuracy of standard MRI and standard MRI with diffusion-weighted imaging with background body signal suppression (DWIBS) for the correct pre-therapeutic assessment of the definite FIGO category. (3) Results: In 7 out of 32 readings (22%), DWIBS improved diagnostic accuracy. With DWIBS, four (13%) additional readings were assigned the correct major (I\u2013IV) FIGO stages pre-therapeutically. Interobserver reliability of DWIBS was weakest for parametrial infiltration (k = 0.43; CI-95% 0.00\u20131.00) and perfect for tumor size &lt;2 cm, infiltration of the vaginal lower third, infiltration of adjacent organs and loco-regional nodal metastases (k = 1.000; CI-95% 1.00\u20131.00). (4) Conclusions: the pre-therapeutic staging of cervical cancer has a high diagnostic accuracy and interobserver reliability when using standard MRI but can be further optimized with the addition of DWIBS sequences when reporting is performed by an experienced radiologist.<\/jats:p>","DOI":"10.3390\/curroncol30010089","type":"journal-article","created":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T06:03:30Z","timestamp":1673849010000},"page":"1164-1173","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Diagnostic Value of Diffusion-Weighted Imaging with Background Body Signal Suppression (DWIBS) for the Pre-Therapeutic Loco-Regional Staging of Cervical Cancer: A Feasibility and Interobserver Reliability Study"],"prefix":"10.3390","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7785-3015","authenticated-orcid":false,"given":"Stephan","family":"Schleder","sequence":"first","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Merciful Brothers Hospital St. Elisabeth, 94315 Straubing, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"May","sequence":"additional","affiliation":[{"name":"Department of Urology, Merciful Brothers Hospital St. Elisabeth, 94315 Straubing, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carsten","family":"Scholz","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Merciful Brothers Hospital St. Elisabeth, 94315 Straubing, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Dinkel","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Medical Center Regensburg, 93055 Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9093-2589","authenticated-orcid":false,"given":"Quirin","family":"Strotzer","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Medical Center Regensburg, 93055 Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingo","family":"Einspieler","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Medical Center Regensburg, 93055 Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Dollinger","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Medical Center Regensburg, 93055 Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas G.","family":"Schreyer","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, University Hospital Brandenburg, Brandenburg Medical School Theodor Fontane, 14770 Brandenburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jochen","family":"Grassinger","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Merciful Brothers Hospital St. Elisabeth, 94315 Straubing, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3648-0996","authenticated-orcid":false,"given":"Andreas","family":"Schicho","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Medical Center Regensburg, 93055 Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"6444","DOI":"10.1007\/s00330-022-08666-x","article-title":"Interobserver agreement and prognostic impact for MRI\u2013based 2018 FIGO staging parameters in uterine cervical cancer","volume":"32","author":"Lura","year":"2022","journal-title":"Eur. 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