{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T17:38:56Z","timestamp":1792431536157,"version":"4.5.0"},"reference-count":57,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T00:00:00Z","timestamp":1675382400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Background: To optimize results reporting after penile cancer (PC) surgery, we proposed a Tetrafecta and assessed its ability to predict overall survival (OS) probabilities. Methods: A purpose-built multicenter, multi-national database was queried for stage I\u2013IIIB PC, requiring inguinal lymphadenectomy (ILND), from 2015 onwards. Kaplan\u2013Meier (KM) method assessed differences in OS between patients achieving Tetrafecta or not. Univariable and multivariable regression analyses identified its predictors. Results: A total of 154 patients were included in the analysis. The 45 patients (29%) that achieved the Tetrafecta were younger (59 vs. 62 years; p = 0.01) and presented with fewer comorbidities (ASA score \u2265 3: 0% vs. 24%; p &lt; 0.001). Although indicated, ILND was omitted in 8 cases (5%), while in 16, a modified template was properly used. Although median LNs yield was 17 (IQR: 11\u201327), 35% of the patients had &lt;7 nodes retrieved from the groin. At Kaplan\u2013Maier analysis, the Tetrafecta cohort displayed significantly higher OS probabilities (Log Rank = 0.01). Uni- and multivariable logistic regression analyses identified age as the only independent predictor of Tetrafecta achievement (OR: 0.97; 95%CI: 0.94\u20130.99; p = 0.04). Conclusions: Our Tetrafecta is the first combined outcome to comprehensively report results after PC surgery. It is widely applicable, based on standardized and reproducible variables and it predicts all-cause mortality.<\/jats:p>","DOI":"10.3390\/curroncol30020146","type":"journal-article","created":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T06:22:25Z","timestamp":1675664545000},"page":"1882-1892","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Combined Reporting of Surgical Quality and Cancer Control after Surgical Treatment for Penile Tumors with Inguinal Lymph Node Dissection: The Tetrafecta Achievement"],"prefix":"10.3390","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9643-8979","authenticated-orcid":false,"given":"Aldo","family":"Brassetti","sequence":"first","affiliation":[{"name":"Department of Urology, IRCCS \u201cRegina Elena\u201d National Cancer Institute, 00144 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7586-4132","authenticated-orcid":false,"given":"Umberto","family":"Anceschi","sequence":"additional","affiliation":[{"name":"Department of Urology, IRCCS \u201cRegina Elena\u201d National Cancer Institute, 00144 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6386-7013","authenticated-orcid":false,"given":"Gabriele","family":"Cozzi","sequence":"additional","affiliation":[{"name":"Department of Urology, European Institute of Oncology, 20141 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0363-5485","authenticated-orcid":false,"given":"Julian","family":"Chavarriaga","sequence":"additional","affiliation":[{"name":"Division of Urology, Clinica Imbanaco, Quiron Salud, Cali 760042, Colombia"},{"name":"Division of Urology, Pontificia Universidad Javeriana, Bogota 110231, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Gavrilov","sequence":"additional","affiliation":[{"name":"Department of Urology, Fondacio Puigvert, 08025 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep Maria","family":"Gaya Sopena","sequence":"additional","affiliation":[{"name":"Department of Urology, Fondacio Puigvert, 08025 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo Maria","family":"Bove","sequence":"additional","affiliation":[{"name":"Department of Urology, IRCCS \u201cRegina Elena\u201d National Cancer Institute, 00144 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3084-6210","authenticated-orcid":false,"given":"Francesco","family":"Prata","sequence":"additional","affiliation":[{"name":"Department of Urology, IRCCS \u201cRegina Elena\u201d National Cancer Institute, 00144 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariaconsiglia","family":"Ferriero","sequence":"additional","affiliation":[{"name":"Department of Urology, IRCCS \u201cRegina Elena\u201d National Cancer Institute, 00144 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3708-2209","authenticated-orcid":false,"given":"Riccardo","family":"Mastroianni","sequence":"additional","affiliation":[{"name":"Department of Urology, IRCCS \u201cRegina Elena\u201d National Cancer Institute, 00144 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Misuraca","sequence":"additional","affiliation":[{"name":"Department of Urology, IRCCS \u201cRegina Elena\u201d National Cancer Institute, 00144 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4480-9090","authenticated-orcid":false,"given":"Gabriele","family":"Tuderti","sequence":"additional","affiliation":[{"name":"Department of Urology, IRCCS \u201cRegina Elena\u201d National Cancer Institute, 00144 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Torregiani","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, IRCCS \u201cRegina Elena\u201d National Cancer Institute, 00144 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Covotta","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, IRCCS \u201cRegina Elena\u201d National Cancer Institute, 00144 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Camacho","sequence":"additional","affiliation":[{"name":"Division of Urologic Oncology Instituto Nacional de Cancerologia, Bogota 111511, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gennaro","family":"Musi","sequence":"additional","affiliation":[{"name":"Department of Urology, European Institute of Oncology, 20141 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo","family":"Varela","sequence":"additional","affiliation":[{"name":"Division of Urologic Oncology Instituto Nacional de Cancerologia, Bogota 111511, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Breda","sequence":"additional","affiliation":[{"name":"Department of Urology, Fondacio Puigvert, 08025 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ottavio","family":"De Cobelli","sequence":"additional","affiliation":[{"name":"Department of Urology, European Institute of Oncology, 20141 Milan, 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