{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:33:16Z","timestamp":1787729596878,"version":"build-2784847793"},"reference-count":27,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T00:00:00Z","timestamp":1675900800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Radiomics is a promising research field that combines big data analysis (from tissue texture analysis) with clinical questions. We studied the application of CT texture analysis in adrenal pheochromocytomas (PCCs) to define the correlation between the extracted features and the secretory pattern, the histopathological data, and the natural history of the disease. A total of 17 patients affected by surgically removed PCCs were retrospectively enrolled. Before surgery, all patients underwent contrast-enhanced CT and complete endocrine evaluation (catecholamine secretion and genetic evaluation). The pheochromocytoma adrenal gland scaled score (PASS) was determined upon histopathological examination. After a resampling of all CT images, the PCCs were delineated using LifeX software in all three phases (unenhanced, arterial, and venous), and 58 texture parameters were extracted for each volume of interest. Using the Mann\u2013Whitney test, the correlations between the hormonal hypersecretion, the malignancy score of the lesion (PASS &gt; 4), and texture parameters were studied. The parameters DISCRETIZED_HUpeak and GLZLM_GLNU in the unenhanced phase and GLZLM_SZE, CONVENTIONAL_HUmean, CONVENTIONAL_HUQ3, DISCRETIZED_HUmean, DISCRETIZED_AUC_CSH, GLRLM_HGRE, and GLZLM_SZHGE in the venous phase were able to differentiate secreting PCCs (p &lt; 0.01), and the parameters GLZLM_GLNU in the unenhanced phase and GLRLM_GLNU and GLRLM_RLNU in the venous differentiated tumors with low and high PASS. CT texture analysis of adrenal PCCs can be a useful tool for the early identification of secreting or malignant tumors.<\/jats:p>","DOI":"10.3390\/curroncol30020167","type":"journal-article","created":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T05:51:06Z","timestamp":1676008266000},"page":"2169-2177","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["CT Texture Analysis of Adrenal Pheochromocytomas: A Pilot Study"],"prefix":"10.3390","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6822-1430","authenticated-orcid":false,"given":"Filippo","family":"Crim\u00ec","sequence":"first","affiliation":[{"name":"Department of Medicine (DIMED), University of Padova, Via Giustiniani 2, 35128 Padova, Italy"},{"name":"Institute of Radiology, Padova University Hospital, Via Giustiniani 2, 35128 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Agostini","sequence":"additional","affiliation":[{"name":"Department of Medicine (DIMED), University of Padova, Via Giustiniani 2, 35128 Padova, Italy"},{"name":"Institute of Radiology, Padova University Hospital, Via Giustiniani 2, 35128 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Toniolo","sequence":"additional","affiliation":[{"name":"Department of Medicine (DIMED), University of Padova, Via Giustiniani 2, 35128 Padova, Italy"},{"name":"Institute of Radiology, Padova University Hospital, Via Giustiniani 2, 35128 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8543-9300","authenticated-orcid":false,"given":"Francesca","family":"Torresan","sequence":"additional","affiliation":[{"name":"Department of Surgical, Oncological and Gastroenterological Sciences, University of Padova, Via Giustiniani 2, 35128 Padova, Italy"},{"name":"Endocrine Surgery Unit, Padova University Hospital, Via Giustiniani 2, 35128 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6057-4642","authenticated-orcid":false,"given":"Maurizio","family":"Iacobone","sequence":"additional","affiliation":[{"name":"Department of Surgical, Oncological and Gastroenterological Sciences, University of Padova, Via Giustiniani 2, 35128 Padova, Italy"},{"name":"Endocrine Surgery Unit, Padova University Hospital, Via Giustiniani 2, 35128 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Tizianel","sequence":"additional","affiliation":[{"name":"Department of Medicine (DIMED), University of Padova, Via Giustiniani 2, 35128 Padova, Italy"},{"name":"Endocrinology Unit, Padova University Hospital, Via Giustiniani 2, 35128 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Scaroni","sequence":"additional","affiliation":[{"name":"Department of Medicine (DIMED), University of Padova, Via Giustiniani 2, 35128 Padova, Italy"},{"name":"Endocrinology Unit, Padova University Hospital, Via Giustiniani 2, 35128 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2020-9365","authenticated-orcid":false,"given":"Emilio","family":"Quaia","sequence":"additional","affiliation":[{"name":"Department of Medicine (DIMED), University of Padova, Via Giustiniani 2, 35128 Padova, Italy"},{"name":"Institute of Radiology, Padova University Hospital, Via Giustiniani 2, 35128 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2105-8554","authenticated-orcid":false,"given":"Cristina","family":"Campi","sequence":"additional","affiliation":[{"name":"Department of Mathematics (DIMA), University of Genova, Via Dodecaneso 33, 16146 Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1456-8716","authenticated-orcid":false,"given":"Filippo","family":"Ceccato","sequence":"additional","affiliation":[{"name":"Department of Medicine (DIMED), University of Padova, Via Giustiniani 2, 35128 Padova, Italy"},{"name":"Endocrinology Unit, Padova University Hospital, Via Giustiniani 2, 35128 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1210\/jc.2014-1498","article-title":"Pheochromocytoma and paraganglioma: An endocrine society clinical practice guideline","volume":"99","author":"Lenders","year":"2014","journal-title":"J. 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