{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T20:26:53Z","timestamp":1772224013091,"version":"3.50.1"},"reference-count":38,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,3,11]],"date-time":"2023-03-11T00:00:00Z","timestamp":1678492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>As the global incidence of multiple myeloma (MM) increases, the identification of modifiable risk factors for disease prevention becomes paramount. Maintaining optimal vitamin D status is a candidate for prevention efforts, based on pre-clinical evidence of a possible role in disease activity and progression. A structured scoping review was performed to identify and describe human-level research regarding the association between vitamin D and MM risk and\/or prognosis. Searches of three databases (OVID-Medline, OVID-Embase, and OVID-Cochrane Library) yielded 15 included publications. Vitamin D deficiency is fairly common among patients with MM, with 42.3% of participants in the studies identified as having a vitamin D deficiency. No included publication reported on vitamin D status and the risk of developing or being newly diagnosed with MM. Possible associations with vitamin D that warrant future exploration include the incident staging of MM disease, the occurrence of peripheral neuropathy, and survival\/prognosis. Vitamin D receptor (VDR) polymorphisms associated with MM also warrant further investigation. Overall, this scoping review was effective in mapping the research regarding vitamin D and MM and may help support new hypotheses to better describe this association and to better address identified knowledge gaps in the literature.<\/jats:p>","DOI":"10.3390\/curroncol30030248","type":"journal-article","created":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T07:28:15Z","timestamp":1678692495000},"page":"3263-3276","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Vitamin D and Multiple Myeloma: A Scoping Review"],"prefix":"10.3390","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5124-3254","authenticated-orcid":false,"given":"Naghmeh","family":"Mirhosseini","sequence":"first","affiliation":[{"name":"The Patterson Institute for Integrative Oncology Research, Toronto, ON M2K 1E2, Canada"},{"name":"Kingston Integrative Healthcare Center (KIHC), Kingston, ON K7L 4T6, Canada"},{"name":"School of Public Health, University of Saskatchewan, Saskatoon, SK S7N 2Z4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athanasios","family":"Psihogios","sequence":"additional","affiliation":[{"name":"The Patterson Institute for Integrative Oncology Research, Toronto, ON M2K 1E2, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meagan D.","family":"McLaren","sequence":"additional","affiliation":[{"name":"The Centre for Health Innovation, Ottawa, ON K2P 0M7, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4893-5254","authenticated-orcid":false,"given":"Dugald","family":"Seely","sequence":"additional","affiliation":[{"name":"The Patterson Institute for Integrative Oncology Research, Toronto, ON M2K 1E2, Canada"},{"name":"The Centre for Health Innovation, Ottawa, ON K2P 0M7, Canada"},{"name":"Ottawa Hospital Research Institute, Ottawa, ON K1Y 4E9, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1001\/jama.2022.0003","article-title":"Diagnosis and Management of Multiple Myeloma: A Review","volume":"327","author":"Cowan","year":"2022","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Padala, S.A., Barsouk, A., Barsouk, A., Rawla, P., Vakiti, A., Kolhe, R., Kota, V., and Ajebo, G.H. 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