{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T03:14:57Z","timestamp":1792984497615,"version":"4.5.0"},"reference-count":135,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T00:00:00Z","timestamp":1678752000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Inflammatory proteins activate platelets, which have been observed to be directly related to cancer progression and development. The aim of this systematic review is to investigate the possible association between Mean Platelet Volume (MPV) and cancer (diagnostic capacity of MPV, relation to survival, the severity of the disease, and metastasis). A literature review was performed in the online database PubMed and Google Scholar for the period of 2010\u20132022. In total, 83 studies including 21,034 participants with 12 different types of cancer (i.e., gastric cancer, colon cancer, esophageal squamous cell carcinoma, renal cancer, breast cancer, ovarian cancer, endometrial cancer, thyroid cancer, lung cancer, bladder cancer, gallbladder cancer, and multiple myeloma) were identified. The role of MPV has been extensively investigated in several types of cancer, such as gastric, colon, breast, and lung cancer, while few data exist for other types, such as renal, gallbladder cancer, and multiple myeloma. Most studies in gastric, breast, endometrium, thyroid, and lung cancer documented an elevated MPV in cancer patients. Data were less clear-cut for esophageal, ovarian, and colon cancer, while reduced MPV was observed in renal cell carcinoma and gallbladder cancer. Several studies on colon cancer (4 out of 6) and fewer on lung cancer (4 out of 10) indicated an unfavorable role of increased MPV regarding mortality. As far as other cancer types are concerned, fewer studies were conducted. MPV can be used as a potential biomarker in cancer diagnosis and could be a useful tool for the optimization of treatment strategies. Possible underlying mechanisms between cancer and MPV are discussed. However, further studies are needed to elucidate the exact role of MPV in cancer progression and metastasis.<\/jats:p>","DOI":"10.3390\/curroncol30030258","type":"journal-article","created":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T06:36:36Z","timestamp":1678862196000},"page":"3391-3420","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Relation of Mean Platelet Volume (MPV) with Cancer: A Systematic Review with a Focus on Disease Outcome on Twelve Types of Cancer"],"prefix":"10.3390","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1723-9192","authenticated-orcid":false,"given":"Paraskevi","family":"Detopoulou","sequence":"first","affiliation":[{"name":"Department of Clinical Nutrition, General Hospital Korgialenio Benakio, Athanassaki 2, 11526 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George I.","family":"Panoutsopoulos","sequence":"additional","affiliation":[{"name":"Department of Nutritional Science and Dietetics, Faculty of Health Sciences, University of Peloponnese, New Building, Antikalamos, 24100 Kalamata, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Mantoglou","sequence":"additional","affiliation":[{"name":"Laboratory of Basic Health Sciences, Department of Nursing, Faculty of Health Sciences, University of Peloponnese, 22100 Tripoli, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Periklis","family":"Michailidis","sequence":"additional","affiliation":[{"name":"Laboratory of Basic Health Sciences, Department of Nursing, Faculty of Health Sciences, University of Peloponnese, 22100 Tripoli, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ifigenia","family":"Pantazi","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, General Hospital Korgialenio Benakio, Athanassaki 2, 11526 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spyros","family":"Papadopoulos","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, General Hospital Korgialenio Benakio, Athanassaki 2, 11526 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Paola","family":"Rojas Gil","sequence":"additional","affiliation":[{"name":"Laboratory of Basic Health Sciences, Department of Nursing, Faculty of Health Sciences, University of Peloponnese, 22100 Tripoli, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/S0140-6736(18)30156-9","article-title":"The Global Fight against Cancer: Challenges and Opportunities","volume":"391","author":"Atun","year":"2018","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"eaay9040","DOI":"10.1126\/science.aay9040","article-title":"Early Detection of Cancer","volume":"375","author":"Crosby","year":"2022","journal-title":"Science"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.3892\/ol.2016.4913","article-title":"Mean Platelet Volume Provides Beneficial Diagnostic and Prognostic Information for Patients with Resectable Gastric Cancer","volume":"12","author":"Shen","year":"2016","journal-title":"Oncol. Lett."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"939089","DOI":"10.3389\/fonc.2022.939089","article-title":"Emerging Roles of Platelets in Cancer Biology and Their Potential as Therapeutic Targets","volume":"12","author":"Wang","year":"2022","journal-title":"Front. Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/s41569-018-0110-0","article-title":"Platelet Biology and Functions: New Concepts and Clinical Perspectives","volume":"16","author":"Heemskerk","year":"2019","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Chatterjee, M., Ehrenberg, A., Toska, L.M., Metz, L.M., Klier, M., Krueger, I., Reusswig, F., and Elvers, M. (2020). Molecular Drivers of Platelet Activation: Unraveling Novel Targets for Anti-Thrombotic and Anti-Thrombo-Inflammatory Therapy. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21217906"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.metabol.2011.07.006","article-title":"Mediterranean Wild Plants Reduce Postprandial Platelet Aggregation in Patients with Metabolic Syndrome","volume":"61","author":"Fragopoulou","year":"2012","journal-title":"Metabolism"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.clinbiochem.2008.09.113","article-title":"Platelet Activating Factor (PAF) and Activity of Its Biosynthetic and Catabolic Enzymes in Blood and Leukocytes of Male Patients with Newly Diagnosed Heart Failure","volume":"42","author":"Detopoulou","year":"2009","journal-title":"Clin. Biochem."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1111\/jth.14788","article-title":"Large and Small Platelets\u2014(When) Do They Differ?","volume":"18","author":"Handtke","year":"2020","journal-title":"J. Thromb. Haemost."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"9213074","DOI":"10.1155\/2019\/9213074","article-title":"Mean Platelet Volume (MPV): New Perspectives for an Old Marker in the Course and Prognosis of Inflammatory Conditions","volume":"2019","author":"Korniluk","year":"2019","journal-title":"Mediat. Inflamm."},{"key":"ref_11","first-page":"191","article-title":"The Role of Platelet-Activating Factor in Chronic Inflammation, Immune Activation, and Comorbidities Associated with HIV Infection","volume":"17","author":"Kelesidis","year":"2015","journal-title":"AIDS Rev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3959","DOI":"10.1038\/s41598-019-40589-4","article-title":"Prognostic Significance of Mean Platelet Volume on Local Advanced Non-Small Cell Lung Cancer Managed with Chemoradiotherapy","volume":"9","author":"Sakin","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_13","first-page":"6036979","article-title":"Combined Diagnostic Efficacy of Neutrophil-to-Lymphocyte Ratio (NLR), Platelet-to-Lymphocyte Ratio (PLR), and Mean Platelet Volume (MPV) as Biomarkers of Systemic Inflammation in the Diagnosis of Colorectal Cancer","volume":"2019","author":"Stankovic","year":"2019","journal-title":"Dis. Markers"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.7314\/APJCP.2015.16.7.2671","article-title":"Mean Platelet Volume Could Be a Possible Biomarker for Papillary Thyroid Carcinomas","volume":"16","author":"Baldane","year":"2015","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_15","first-page":"1769","article-title":"Decreased Mean Platelet Volume Is Associated with Cervical Cancer Development","volume":"18","author":"Shen","year":"2017","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1007\/s12282-015-0635-6","article-title":"Pre-Treatment Mean Platelet Volume Associates with Worse Clinicopathologic Features and Prognosis of Patients with Invasive Breast Cancer","volume":"23","author":"Gu","year":"2016","journal-title":"Breast Cancer"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"859","DOI":"10.2174\/1871530319666190206125545","article-title":"Comparison of Mean Platelet Volume, Platelet Count, Neutrophil\/Lymphocyte Ratio and Platelet\/Lymphocyte Ratio in the Euthyroid, Overt Hypothyroid and Subclinical Hyperthyroid Phases of Papillary Thyroid Carcinoma","volume":"19","author":"Kutluturk","year":"2019","journal-title":"Endocr. Metab. Immune Disord. Drug Targets"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1007\/s10147-017-1158-2","article-title":"Association of Decreased Mean Platelet Volume with Renal Cell Carcinoma","volume":"22","author":"Yun","year":"2017","journal-title":"Int. J. Clin. Oncol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Chang, J., Lin, G., Ye, M., Tong, D., Zhao, J., Zhu, D., Yu, Q., Zhang, W., and Li, W. (2019). Decreased Mean Platelet Volume Predicts Poor Prognosis in Metastatic Colorectal Cancer Patients Treated with First-Line Chemotherapy: Results from MCRC Biomarker Study. BMC Cancer, 19.","DOI":"10.1186\/s12885-018-5252-2"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"dox125","DOI":"10.1093\/dote\/dox125","article-title":"The Clinical Implications of Mean Platelet Volume and Mean Platelet Volume\/Platelet Count Ratio in Locally Advanced Esophageal Squamous Cell Carcinoma","volume":"31","author":"Sun","year":"2018","journal-title":"Dis. Esophagus"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"6014","DOI":"10.1038\/s41598-018-24539-0","article-title":"Mean Platelet Volume Predicts Survival in Pancreatic Cancer Patients with Synchronous Liver Metastases","volume":"8","author":"Yin","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_22","first-page":"351","article-title":"Mean Platelet Volume and Platelet Distribution Width Are Associated with Gallbladder Cancer","volume":"19","author":"Zhang","year":"2018","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0140-6736(20)31288-5","article-title":"Gastric Cancer","volume":"396","author":"Smyth","year":"2020","journal-title":"Lancet"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"722","DOI":"10.3109\/09537104.2016.1169265","article-title":"Diagnostic and Prognostic Roles of the Mean Platelet Volume in Malignant Tumors: A Systematic Review and Meta-Analysis","volume":"27","author":"Pyo","year":"2016","journal-title":"Platelets"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"103427","DOI":"10.1016\/j.critrevonc.2021.103427","article-title":"Prognostic Value of Platelet-Related Measures for Overall Survival in Esophageal Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis","volume":"164","author":"Ishibashi","year":"2021","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"3000605221084874","DOI":"10.1177\/03000605221084874","article-title":"Prognostic Significance of Mean Platelet Volume in Patients with Lung Cancer: A Meta-Analysis","volume":"50","author":"Kharel","year":"2022","journal-title":"J. Int. Med. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s10654-010-9491-z","article-title":"Critical Evaluation of the Newcastle-Ottawa Scale for the Assessment of the Quality of Nonrandomized Studies in Meta-Analyses","volume":"25","author":"Stang","year":"2010","journal-title":"Eur. J. Epidemiol."},{"key":"ref_28","unstructured":"Wells, G., Shea, B., O\u2019Connell, D., Peterson, J., Welch, V., Losos, M., and Tugwell, P. (2023, March 13). The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta-Analyses. Available online: https:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e011458","DOI":"10.1136\/bmjopen-2016-011458","article-title":"Development of a Critical Appraisal Tool to Assess the Quality of Cross-Sectional Studies (AXIS)","volume":"6","author":"Downes","year":"2016","journal-title":"BMJ Open"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 Statement: An Updated Guideline for Reporting Systematic Reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"183","DOI":"10.5114\/pg.2019.88167","article-title":"The Importance of Complete Blood Count Parameters in the Screening of Gastric Cancer","volume":"14","author":"Aksoy","year":"2019","journal-title":"Gastroenterol. Rev. \/Przegl\u0105d Gastroenterol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/435672","article-title":"Platelets and Inflammatory Markers in Patients with Gastric Cancer","volume":"2013","author":"Kamocki","year":"2013","journal-title":"Clin. Dev. Immunol."},{"key":"ref_33","first-page":"4433","article-title":"Diagnostic Power of Blood Parameters as Screening Markers in Gastric Cancer Patients","volume":"17","author":"Pietrzyk","year":"2016","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"592","DOI":"10.3109\/09537104.2013.783689","article-title":"Mean Platelet Volume Could Be Possible Biomarker in Early Diagnosis and Monitoring of Gastric Cancer","volume":"25","author":"Ekiz","year":"2014","journal-title":"Platelets"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"3419","DOI":"10.3892\/ol.2015.3784","article-title":"Mean Platelet Volume Predicts Chemotherapy Response and Prognosis in Patients with Unresectable Gastric Cancer","volume":"10","author":"Lian","year":"2015","journal-title":"Oncol. Lett."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e30504","DOI":"10.1097\/MD.0000000000030504","article-title":"Preoperative Mean Platelet Volume Is a Prognostic Biomarker for Survival in Patients with Gastric Cancer: A Cohort Study","volume":"101","author":"An","year":"2022","journal-title":"Medicine"},{"key":"ref_37","first-page":"e9109","article-title":"Role of Mean Platelet Volume in the Prognosis of Locally Advanced Gastric Cancer: A Tertiary Cancer Center Experience","volume":"12","author":"Manjunath","year":"2020","journal-title":"Cureus"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"10261","DOI":"10.1038\/s41598-017-11053-y","article-title":"Elevated Mean Platelet Volume Predicts Poor Prognosis in Colorectal Cancer","volume":"7","author":"Li","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"10501","DOI":"10.7314\/APJCP.2014.15.23.10501","article-title":"Elevated Mean Platelet Volume Is Associated with Presence of Colon Cancer","volume":"15","author":"Li","year":"2014","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"6421","DOI":"10.7314\/APJCP.2014.15.15.6421","article-title":"Mean Platelet Volume as a Prognostic Marker in Metastatic Colorectal Cancer Patients Treated with Bevacizumab-Combined Chemotherapy","volume":"15","author":"Tuncel","year":"2014","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1002\/cam4.2896","article-title":"Nomogram for Predicting Overall Survival in Stage II-III Colorectal Cancer","volume":"9","author":"Liu","year":"2020","journal-title":"Cancer Med."},{"key":"ref_42","first-page":"227","article-title":"Mean Platelet Volume and Platelet Distribution Width Correlates with Prognosis of Early Colon Cancer","volume":"25","author":"Sakin","year":"2020","journal-title":"J. BUON"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.canrad.2020.06.030","article-title":"Prognostic Value of Platelet-Associated Biomarkers in Rectal Cancer Patients Received Neoadjuvant Chemoradiation: A Retrospective Study","volume":"25","author":"Wang","year":"2021","journal-title":"Cancer Radiother."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Alsalman, A., Al-Mterin, M.A., Abu-Dayeh, A., Alloush, F., Murshed, K., and Elkord, E. (2022). Associations of Complete Blood Count Parameters with Disease-Free Survival in Right- and Left-Sided Colorectal Cancer Patients. J. Pers. Med., 12.","DOI":"10.3390\/jpm12050816"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"10732748221091332","DOI":"10.1177\/10732748221091333","article-title":"Predictive Values of the Selected Inflammatory Indexes in Colon Cancer","volume":"29","author":"Huang","year":"2022","journal-title":"Cancer Control"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"351","DOI":"10.3233\/CBM-203250","article-title":"Decreased Mean Platelet Volume Is Associated with Microsatellite Instability in Colorectal Cancer: A Propensity Score-Matched Analysis","volume":"31","author":"Wang","year":"2021","journal-title":"Cancer Biomark."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e7246","DOI":"10.7717\/peerj.7246","article-title":"Prognostic Value of Mean Platelet Volume\/Platelet Count Ratio in Patients with Resectable Esophageal Squamous Cell Carcinoma: A Retrospective Study","volume":"7","author":"Feng","year":"2019","journal-title":"PeerJ"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1067682","DOI":"10.3389\/fonc.2022.1067682","article-title":"Adjuvant Chemotherapy for Lymph Node Positive Esophageal Squamous Cell Cancer: The Prediction Role of Low Mean Platelet Volume","volume":"12","author":"Liu","year":"2022","journal-title":"Front. Oncol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"4739","DOI":"10.7150\/jca.56029","article-title":"Predictive Value of Routine Blood Test in Patients with Early Esophageal Cancer: A Matched Case-Control Study","volume":"12","author":"Zhou","year":"2021","journal-title":"J. Cancer"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1007\/s12149-015-1020-4","article-title":"The Correlation between the Metabolic Tumor Volume and Hematological Parameters in Patients with Esophageal Cancer","volume":"29","author":"Demir","year":"2015","journal-title":"Ann. Nucl. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"6700","DOI":"10.1038\/s41598-017-07168-x","article-title":"Lower Mean Platelet Volume Predicts Poor Prognosis in Renal Cell Carcinoma","volume":"7","author":"Yun","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/8687575","article-title":"Basic Parameters of Blood Count as Prognostic Factors for Renal Cell Carcinoma","volume":"2016","author":"Prokopowicz","year":"2016","journal-title":"BioMed Res. Int."},{"key":"ref_53","first-page":"1743","article-title":"Prognostic Value of Preoperative Inflammatory Markers in Chinese Patients with Breast Cancer","volume":"7","author":"Yao","year":"2014","journal-title":"OncoTargets Ther."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.3892\/ol.2016.4760","article-title":"White Blood Cell and Platelet Indices as Prognostic Markers in Patients with Invasive Ductal Breast Carcinoma","volume":"12","author":"Mantas","year":"2016","journal-title":"Oncol. Lett."},{"key":"ref_55","first-page":"840","article-title":"The Mean Platelet Volume May Predict the Development of Isolated Bone Metastases in Patients with Breast Cancer: A Retrospective Study of the Young Researchers Committee of the Turkish Oncology Group (TOG)","volume":"21","author":"Tanriverdi","year":"2016","journal-title":"J. BUON"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.7314\/APJCP.2016.17.4.2089","article-title":"Mean Platelet Volume as an Independent Predictive Marker for Pathologic Complete Response after Neoadjuvant Chemotherapy in Patients with Locally Advanced Breast Cancer","volume":"17","author":"Mutlu","year":"2016","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"5090","DOI":"10.12659\/MSM.906709","article-title":"Clinical Significance of Routine Blood Test-Associated Inflammatory Index in Breast Cancer Patients","volume":"23","author":"Sun","year":"2017","journal-title":"Med. Sci. Monit."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"220","DOI":"10.29271\/jcpsp.2022.02.220","article-title":"Immature Granulocyte Count and Delta Neutrophil Index as New Predictive Factors for Axillary Metastasis of Breast Cancer","volume":"32","author":"Bozan","year":"2022","journal-title":"J. Coll. Physicians Surg. Pak."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.7754\/Clin.Lab.2020.201103","article-title":"Hematological Parameters Changes in Patients with Breast Cancer","volume":"67","author":"Divsalar","year":"2021","journal-title":"Clin. Lab."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s13048-018-0382-3","article-title":"Single and Combined Use of Red Cell Distribution Width, Mean Platelet Volume, and Cancer Antigen 125 for Differential Diagnosis of Ovarian Cancer and Benign Ovarian Tumors","volume":"11","author":"Qin","year":"2018","journal-title":"J. Ovarian Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"515","DOI":"10.3109\/01443615.2014.912620","article-title":"Mean Platelet Volume Could Be a Useful Biomarker for Monitoring Epithelial Ovarian Cancer","volume":"34","author":"Kemal","year":"2014","journal-title":"J. Obstet. Gynaecol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/jog.12151","article-title":"Prognostic Significance of Thrombocytosis, Platelet Parameters and Aggregation Rates in Epithelial Ovarian Cancer: Platelet Count, Aggregation Rate and EOC","volume":"40","author":"Ma","year":"2014","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"9781","DOI":"10.7314\/APJCP.2014.15.22.9781","article-title":"May the Platelet to Lymphocyte Ratio Be a Prognostic Factor for Epithelial Ovarian Cancer?","volume":"15","author":"Kokcu","year":"2014","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"21","DOI":"10.5152\/jtgga.2015.0152","article-title":"Utility of Preoperative Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios to Distinguish Malignant from Benign Ovarian Masses","volume":"17","author":"Bakacak","year":"2016","journal-title":"J. Turk. Ger. Gynecol. Assoc."},{"key":"ref_65","first-page":"346","article-title":"MPV, NLR, and Platelet Count: New Hematologic Markers in Diagnosis of Malignant Ovarian Tumor","volume":"38","author":"Yilmaz","year":"2017","journal-title":"Eur. J. Gynaecol. Oncol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"5397","DOI":"10.7314\/APJCP.2015.16.13.5397","article-title":"Platelet Indices May Be Useful in Discrimination of Benign and Malign Endometrial Lesions, and Early and Advanced Stage Endometrial Cancer","volume":"16","author":"Kurtoglu","year":"2015","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"e23309","DOI":"10.1002\/jcla.23309","article-title":"Clinical Application of Red Cell Distribution Width, Mean Platelet Volume, and Cancer Antigen 125 Detection in Endometrial Cancer","volume":"34","author":"Zhang","year":"2020","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ejogrb.2018.05.028","article-title":"Prognostic Value of Pre-Operative Neutrophil\/Lymphocyte Ratio, Monocyte Count, Mean Platelet Volume, and Platelet\/Lymphocyte Ratio in Endometrial Cancer","volume":"226","author":"Temur","year":"2018","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"4905","DOI":"10.7314\/APJCP.2015.16.12.4905","article-title":"Relations of Platelet Indices with Endometrial Hyperplasia and Endometrial Cancer","volume":"16","author":"Karateke","year":"2015","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"301","DOI":"10.3109\/01443615.2012.758089","article-title":"Platelet Volume as a Parameter for Platelet Activation in Patients with Endometrial Cancer","volume":"33","author":"Oge","year":"2013","journal-title":"J. Obstet. Gynaecol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"e17818","DOI":"10.1097\/MD.0000000000017818","article-title":"Preoperative Platelet Morphology Parameters as Prognostic Predictors for Endometrial Malignant Carcinoma Stage and Progesterone Receptor","volume":"98","author":"Song","year":"2019","journal-title":"Medicine"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.ygyno.2020.05.040","article-title":"Nomograms Based on the Novel Platelet Index Score Predict Postoperative Prognosis in Endometrial Cancer","volume":"158","author":"Chen","year":"2020","journal-title":"Gynecol. Oncol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"e22438","DOI":"10.1002\/jcla.22438","article-title":"Evaluation of Complete Blood Count Parameters to Predict Endometrial Cancer","volume":"32","author":"Cogendez","year":"2018","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"594","DOI":"10.4149\/neo_2017_414","article-title":"Preoperative Mean Platelet Volume and Platelet Distribution Associated with Thyroid Cancer","volume":"64","author":"Yu","year":"2017","journal-title":"Neoplasma"},{"key":"ref_75","first-page":"417","article-title":"Mean Platelet Volume: An Overlooked Herald of Malignant Thyroid Nodules","volume":"58","author":"Sit","year":"2019","journal-title":"Acta Clin. Croat."},{"key":"ref_76","first-page":"153","article-title":"Evaluation of Platelet Indices as a Useful Marker in Papillary Thyroid Carcinoma","volume":"118","author":"Dincel","year":"2017","journal-title":"Bratisl. Lek. Listy"},{"key":"ref_77","first-page":"1642","article-title":"A Comparison of Hemogram Parameters of Patients with Thyroid Papillary Cancer and Nodular Goiter","volume":"69","author":"Yildiz","year":"2019","journal-title":"J. Pak. Med. Assoc."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"50","DOI":"10.9738\/INTSURG-D-15-00123.1","article-title":"Mean Platelet Volume as a Biomarker for Thyroid Carcinoma","volume":"101","author":"Bayhan","year":"2016","journal-title":"Int. Surg."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Martin, S., Mustata, T., Enache, O., Ion, O., Chifulescu, A., Sirbu, A., Barbu, C., Miron, A., Giulea, C., and Andrei, F. (2021). Platelet Activation and Inflammation in Patients with Papillary Thyroid Cancer. Diagnostics, 11.","DOI":"10.3390\/diagnostics11111959"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"984157","DOI":"10.3389\/fendo.2022.984157","article-title":"Prognostic Significance of Inflammatory Markers LMR, PLR, MPV, FIB in Intermediate-and High-Risk Papillary Thyroid Carcinoma","volume":"13","author":"Li","year":"2022","journal-title":"Front. Endocrinol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"861869","DOI":"10.3389\/fendo.2022.861869","article-title":"Prognostic Impact of Inflammatory Markers PLR, LMR, PDW, MPV in Medullary Thyroid Carcinoma","volume":"13","author":"Li","year":"2022","journal-title":"Front. Endocrinol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"3456","DOI":"10.1038\/s41598-017-03772-z","article-title":"Platelet Distribution Width Correlates with Prognosis of Non-Small Cell Lung Cancer","volume":"7","author":"Cui","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"8965","DOI":"10.2147\/CMAR.S215361","article-title":"Prognostic Significance Of Platelet-To-Lymphocyte Ratio (PLR) And Mean Platelet Volume (MPV) During Etoposide-Based First-Line Treatment In Small Cell Lung Cancer Patients","volume":"11","author":"Shen","year":"2019","journal-title":"Cancer Manag. Res."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"8655","DOI":"10.12659\/MSM.911125","article-title":"Predictable Resistance and Overall Survival of Gemcitabine\/Cisplatin by Platelet Activation Index in Non-Small Cell Lung Cancer","volume":"24","author":"Shi","year":"2018","journal-title":"Med. Sci. Monit."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"153303381983726","DOI":"10.1177\/1533033819837261","article-title":"Prognostic Values of Platelet-Associated Indicators in Resectable Lung Cancers","volume":"18","author":"Wang","year":"2019","journal-title":"Technol. Cancer Res. Treat."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1371964","DOI":"10.1155\/2020\/1371964","article-title":"Absolute Neutrophil Count and Mean Platelet Volume in the Blood as Biomarkers to Detect Lung Cancer","volume":"2020","author":"Zhu","year":"2020","journal-title":"Dis. Markers"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.cca.2020.05.043","article-title":"Integration of Platelet Features in Blood and Platelet Rich Plasma for Detection of Lung Cancer","volume":"509","author":"Zu","year":"2020","journal-title":"Clin. Chim. Acta."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"5653033","DOI":"10.1155\/2022\/5653033","article-title":"Use of Platelet Parameters in the Differential Diagnosis of Lung Adenocarcinoma-Associated Malignant Pleural Effusion and Tuberculous Pleural Effusion","volume":"2022","author":"Ai","year":"2022","journal-title":"Dis. Markers"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.31557\/APJCP.2019.20.6.1879","article-title":"Effect of Pretreatment Platelet Parameters on Survival in Limited Disease Small Cell Lung Cancer","volume":"20","author":"Sakin","year":"2019","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1111\/crj.12605","article-title":"Role of Increased Mean Platelet Volume (MPV) and Decreased MPV\/Platelet Count Ratio as Poor Prognostic Factors in Lung Cancer","volume":"12","author":"Omar","year":"2018","journal-title":"Clin. Respir. J."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1080\/07357907.2021.1938110","article-title":"The Role of Hematological Inflammatory Biomarkers in the Diagnosis of Lung Cancer and in Predicting TNM Stage","volume":"39","author":"Goksel","year":"2021","journal-title":"Cancer Invest."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Watanabe, K., Yasumoto, A., Amano, Y., Kage, H., Goto, Y., Yatomi, Y., Takai, D., and Nagase, T. (2018). Mean Platelet Volume and Lymphocyte-to-Monocyte Ratio Are Associated with Shorter Progression-Free Survival in EGFR-Mutant Lung Adenocarcinoma Treated by EGFR Tyrosine Kinase Inhibitor. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0203625"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"197","DOI":"10.3892\/mco.2014.436","article-title":"Prognostic Significance of Preoperative Mean Platelet Volume in Resected Non-Small-Cell Lung Cancer","volume":"3","author":"Kumagai","year":"2015","journal-title":"Mol. Clin. Oncol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"2800","DOI":"10.7150\/jca.41122","article-title":"Preoperative Plateletcrit Is a Prognostic Biomarker for Survival in Patients with Non-Small Cell Lung Cancer","volume":"11","author":"Hur","year":"2020","journal-title":"J. Cancer"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.21037\/jtd-21-1401","article-title":"Prognostic Value of Selected Platelet Parameters of Patients Operated for Non-Small Cell Lung Cancer","volume":"14","author":"Zawadzka","year":"2022","journal-title":"J. Thorac. Dis."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1186\/s12967-018-1636-y","article-title":"Predictive Values of the Selected Inflammatory Index in Elderly Patients with Papillary Thyroid Cancer","volume":"16","author":"Wen","year":"2018","journal-title":"J. Transl. Med."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"68115","DOI":"10.18632\/oncotarget.19242","article-title":"Decreased Mean Platelet Volume Predicts Poor Prognosis in Invasive Bladder Cancer","volume":"8","author":"Wang","year":"2017","journal-title":"Oncotarget"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.2217\/fon-2022-0223","article-title":"Prognostic Value of Preoperative Platelet-Related Parameters and Plasma Fibrinogen in Patients with Non-Muscle Invasive Bladder Cancer after Transurethral Resection of Bladder Tumor","volume":"18","author":"Song","year":"2022","journal-title":"Future Oncol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"3797","DOI":"10.2217\/fon-2019-0441","article-title":"Evaluation of Platelet Distribution Width as a Diagnostic and Prognostic Biomarker in Bladder Neoplasm","volume":"15","author":"Liu","year":"2019","journal-title":"Future Oncol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.kjms.2016.05.001","article-title":"Can the Neutrophil-to-Lymphocyte Ratio Be Used to Predict Recurrence and Progression of Non-Muscle-Invasive Bladder Cancer?","volume":"32","author":"Albayrak","year":"2016","journal-title":"Kaohsiung J. Med. Sci."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"e14118","DOI":"10.1111\/ijcp.14118","article-title":"Prognostic Value of Preoperative Inflammation Markers in Non-muscle Invasive Bladder Cancer","volume":"75","author":"Aslan","year":"2021","journal-title":"Int. J. Clin. Pract."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"10732748211033746","DOI":"10.1177\/10732748211033746","article-title":"Diagnostic Value of Inflammatory Factors in Patients with Gallbladder Cancer, Dysplasia, and Cholecystitis","volume":"28","author":"Kucuk","year":"2021","journal-title":"Cancer Control"},{"key":"ref_103","first-page":"e16389","article-title":"Role of Mean Platelet Volume in the Prognosis of Gallbladder Carcinoma: A Tertiary Centre Experience","volume":"13","author":"Prakash","year":"2021","journal-title":"Cureus"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"62640","DOI":"10.18632\/oncotarget.11551","article-title":"The Independent Association of Mean Platelet Volume with Overall Survival in Multiple Myeloma","volume":"7","author":"Zhuang","year":"2016","journal-title":"Oncotarget"},{"key":"ref_105","first-page":"290","article-title":"Surgery for Triple-Negative Breast Cancer- Does the Type of Anaesthesia Have an Influence on Oxidative Stress, Inflammation, Molecular Regulators, and Outcomes of Disease?","volume":"23","author":"Lukoseviciene","year":"2018","journal-title":"J. BUON"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1080\/08923970701675085","article-title":"Enhancement of Antitumor Immunity after Propofol Treatment in Mice","volume":"29","author":"Kushida","year":"2007","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1159\/000088478","article-title":"VEGF as a Key Mediator of Angiogenesis in Cancer","volume":"69","author":"Carmeliet","year":"2005","journal-title":"Oncology"},{"key":"ref_108","first-page":"487","article-title":"Leukocytes and Platelets of Patients with Cancer Contain High Levels of Vascular Endothelial Growth Factor","volume":"5","author":"Salven","year":"1999","journal-title":"Clin. Cancer Res."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"180119","DOI":"10.1183\/16000617.0119-2018","article-title":"Cancer-Associated Thrombosis: The When, How and Why","volume":"28","author":"Fernandes","year":"2019","journal-title":"Eur. Respir. Rev."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/s13045-018-0669-2","article-title":"Role of Platelets and Platelet Receptors in Cancer Metastasis","volume":"11","author":"Schlesinger","year":"2018","journal-title":"J. Hematol. Oncol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s10555-021-09956-4","article-title":"Platelets as Messengers of Early-Stage Cancer","volume":"40","author":"Sabrkhany","year":"2021","journal-title":"Cancer Metastasis Rev."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Lavergne, M., Janus-Bell, E., Schaff, M., Gachet, C., and Mangin, P. (2017). Platelet Integrins in Tumor Metastasis: Do They Represent a Therapeutic Target?. Cancers, 9.","DOI":"10.3390\/cancers9100133"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/(SICI)1097-0215(19970117)70:2<201::AID-IJC11>3.0.CO;2-L","article-title":"Platelets Mediate Tumor Cell Adhesion to the Subendothelium under Flow Conditions: Involvement of Platelet GPIIb-IIIa and Tumor Cell ?V Integrins","volume":"70","author":"Dardik","year":"1997","journal-title":"Int. J. Cancer"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1166\/jbn.2013.1541","article-title":"MMP-2 Detective Silicon Nanowire Biosensor Using Enzymatic Cleavage Reaction","volume":"9","author":"Choi","year":"2013","journal-title":"J. Biomed. Nanotechnol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s40164-022-00273-2","article-title":"The GPIb-IX Complex on Platelets: Insight into Its Novel Physiological Functions Affecting Immune Surveillance, Hepatic Thrombopoietin Generation, Platelet Clearance and Its Relevance for Cancer Development and Metastasis","volume":"11","author":"Bendas","year":"2022","journal-title":"Exp. Hematol. Oncol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1080\/095371002220148332","article-title":"Mean Platelet Volume as an Indicator of Platelet Activation: Methodological Issues","volume":"13","author":"Park","year":"2002","journal-title":"Platelets"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s11239-006-9014-7","article-title":"Platelet Count, Mean Platelet Volume, Platelet Distribution Width, and Plateletcrit Do Not Correlate with Optical Platelet Aggegation Responses in Healthy Volunteers","volume":"22","author":"Beyan","year":"2006","journal-title":"J. Thromb. Thrombolysis"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.lungcan.2013.08.020","article-title":"Prognostic Impact of the Mean Platelet Volume\/Platelet Count Ratio in Terms of Survival in Advanced Non-Small Cell Lung Cancer","volume":"83","author":"Inagaki","year":"2014","journal-title":"Lung Cancer"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.compbiomed.2015.12.023","article-title":"Age and Gender Effects on 15 Platelet Phenotypes in a Spanish Population","volume":"69","author":"Ziyatdinov","year":"2016","journal-title":"Comput. Biol. Med."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1182\/blood-2015-07-660308","article-title":"Sex-Specific Differences in Genetic and Nongenetic Determinants of Mean Platelet Volume: Results from the Gutenberg Health Study","volume":"127","author":"Schulz","year":"2016","journal-title":"Blood"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1080\/09537104.2017.1317732","article-title":"The Genetics of Platelet Count and Volume in Humans","volume":"29","author":"Eicher","year":"2018","journal-title":"Platelets"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1111\/j.1365-2362.1994.tb01076.x","article-title":"Influence of Weight Reduction on Platelet Volume: Different Effects of a Hypocaloric Diet and a Very Low Calorie Diet","volume":"24","author":"Toplak","year":"1994","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1080\/09537100802613449","article-title":"Lifestyle Modification Decreases the Mean Platelet Volume in Prehypertensive Patients","volume":"20","author":"Yazici","year":"2009","journal-title":"Platelets"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1515\/med-2018-0067","article-title":"Is Monitoring Mean Platelet Volume Necessary in Breast Cancer Patients?","volume":"13","author":"Taskaynatan","year":"2018","journal-title":"Open Med."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1097\/MNM.0000000000000452","article-title":"Temporary Changes in Neutrophil-to-Lymphocyte, Platelet-to-Lymphocyte Ratios, and Mean Platelet Volume Reflecting the Inflammatory Process after Radioiodine Therapy","volume":"37","author":"Demir","year":"2016","journal-title":"Nucl. Med. Commun."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1590\/1806-9282.64.06.554","article-title":"Platelets Volume Indexes and Cardiovascular Risk Factors","volume":"64","author":"Batista","year":"2018","journal-title":"Rev. Assoc. Med. Bras."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.htct.2020.07.006","article-title":"The Effect and Correlation of Smoking with Platelet Indices, Neutrophil Lymphocyte Ratio and Platelet Lymphocyte Ratio","volume":"43","author":"Pujani","year":"2021","journal-title":"Hematol. Transfus. Cell Ther."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1093\/eurheartj\/ehab484","article-title":"2021 ESC Guidelines on Cardiovascular Disease Prevention in Clinical Practice","volume":"42","author":"Visseren","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s00408-022-00536-z","article-title":"Cancer, Phase Angle and Sarcopenia: The Role of Diet in Connection with Lung Cancer Prognosis","volume":"200","author":"Detopoulou","year":"2022","journal-title":"Lung"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1476-511X-8-19","article-title":"Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Activity, Platelet-Activating Factor Acetylhydrolase (PAF-AH) in Leukocytes and Body Composition in Healthy Adults","volume":"8","author":"Detopoulou","year":"2009","journal-title":"Lipids Health Dis."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00394-014-0682-3","article-title":"The Relation of Diet with PAF and Its Metabolic Enzymes in Healthy Volunteers","volume":"54","author":"Detopoulou","year":"2015","journal-title":"Eur. J. Nutr."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"102234","DOI":"10.1016\/j.plefa.2020.102234","article-title":"Associations between Red Blood Cells Fatty Acids, Desaturases Indices and Metabolism of Platelet Activating Factor in Healthy Volunteers","volume":"164","author":"Fragopoulou","year":"2021","journal-title":"Prostaglandins Leukot Essent. Fat Acids"},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Detopoulou, P., Tsiouda, T., Pilikidou, M., Palyvou, F., Tsekitsidi, E., Mantzorou, M., Pezirkianidou, P., Kyrka, K., Methenitis, S., and Voulgaridou, G. (2022). Changes in Body Weight, Body Composition, Phase Angle, and Resting Metabolic Rate in Male Patients with Stage IV Non-Small-Cell Lung Cancer Undergoing Therapy. Medicina, 58.","DOI":"10.3390\/medicina58121779"},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Detopoulou, P., Panoutsopoulos, G.I., Kalonarchi, G., Alexatou, O., Petropoulou, G., and Papamikos, V. (2022). 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Nutrients, 14.","DOI":"10.3390\/nu14163267"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1007\/s11745-002-0977-0","article-title":"Relationship between Platelet Phospholipid FA and Mean Platelet Volume in Healthy Men","volume":"37","author":"Li","year":"2002","journal-title":"Lipids"}],"container-title":["Current Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1718-7729\/30\/3\/258\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:54:55Z","timestamp":1760122495000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1718-7729\/30\/3\/258"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,14]]},"references-count":135,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["curroncol30030258"],"URL":"https:\/\/doi.org\/10.3390\/curroncol30030258","relation":{},"ISSN":["1718-7729"],"issn-type":[{"value":"1718-7729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,14]]}}}