{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:36:27Z","timestamp":1791822987651,"version":"4.3.4"},"reference-count":33,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T00:00:00Z","timestamp":1679443200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Hepatocellular carcinoma (HCC) has multiple molecular classes that are associated with distinct etiologies and, besides particular molecular characteristics, that also differ in clinical aspects. We aim to characterize the clinical aspects of alcoholic liver disease-related HCC by a retrospective observational study that included all consequent patients diagnosed with MRI or histologically verified HCC in participating centers from 2010 to 2016. A total of 429 patients were included in the analysis, of which 412 patients (96%) had cirrhosis at the time of diagnosis. The most common etiologies were alcoholic liver disease (ALD) (48.3%), chronic hepatitis C (14.9%), NAFLD (12.6%), and chronic hepatitis B (10%). Patients with ALD-related HCC were more commonly males, more commonly had cirrhosis that was in more advanced stages, and had poorer performance status. Despite these results, no differences were observed in the overall (median 8.1 vs. 8.5 months) and progression-free survival (median 4.9 vs. 5.7 months). ALD-HCC patients within BCLC stage 0\u2013A less frequently received potentially curative treatment as compared to the control HCC patients (62.2% vs. 87.5%, p = 0.017); and in patients with ALD-HCC liver function (MELD score) seemed to have a stronger influence on the prognosis compared to the control group HCC. Systemic inflammatory indexes were strongly associated with survival in the whole cohort. In conclusion, alcoholic liver disease is the most common cause of hepatocellular carcinoma in Slovakia, accounting for almost 50% of cases; and patients with ALD-related HCC more commonly had cirrhosis that was in more advanced stages and had poorer performance status, although no difference in survival between ALD-related and other etiology-related HCC was observed.<\/jats:p>","DOI":"10.3390\/curroncol30030271","type":"journal-article","created":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T07:46:43Z","timestamp":1679471203000},"page":"3557-3570","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Alcoholic Liver Disease-Related Hepatocellular Carcinoma: Characteristics and Comparison to General Slovak Hepatocellular Cancer Population"],"prefix":"10.3390","volume":"30","author":[{"given":"Dominik","family":"\u0160af\u010d\u00e1k","sequence":"first","affiliation":[{"name":"Department of Radiotherapy and Oncology, East Slovakia Institute of Oncology, 04191 Ko\u0161ice, Slovakia"},{"name":"2nd Department of Internal Medicine, Louis Pasteur University Hospital, 04011 Ko\u0161ice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia","family":"Dra\u017eilov\u00e1","sequence":"additional","affiliation":[{"name":"2nd Department of Internal Medicine, Louis Pasteur University Hospital, 04011 Ko\u0161ice, Slovakia"},{"name":"Department of Internal Medicine, Faculty of Medicine, Pavol Jozef Safarik University in Kosice, 04011 Ko\u0161ice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"Gazda","sequence":"additional","affiliation":[{"name":"2nd Department of Internal Medicine, Louis Pasteur University Hospital, 04011 Ko\u0161ice, Slovakia"},{"name":"Department of Internal Medicine, Faculty of Medicine, Pavol Jozef Safarik University in Kosice, 04011 Ko\u0161ice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Andra\u0161ina","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy and Oncology, East Slovakia Institute of Oncology, 04191 Ko\u0161ice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8181-1937","authenticated-orcid":false,"given":"Svetlana","family":"Adamcov\u00e1-Sel\u010danov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, F.D. Roosevelt University Hospital, 97517 Bansk\u00e1 Bystrica, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radovan","family":"Barila","sequence":"additional","affiliation":[{"name":"Oncological Cluster, Saint Michael Hospital Michalovce, 07101 Michalovce, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6511-6827","authenticated-orcid":false,"given":"Michal","family":"Mego","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology, National Oncology Institute of Slovakia, 83310 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"R\u00e1c","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University Hospital Nitra, 94901 Nitra, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5171-3623","authenticated-orcid":false,"given":"\u013dubom\u00edr","family":"Skladan\u00fd","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, F.D. Roosevelt University Hospital, 97517 Bansk\u00e1 Bystrica, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miroslav","family":"\u017digrai","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University Hospital in Bratislava, 83101 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3329-3968","authenticated-orcid":false,"given":"Martin","family":"Jani\u010dko","sequence":"additional","affiliation":[{"name":"2nd Department of Internal Medicine, Louis Pasteur University Hospital, 04011 Ko\u0161ice, Slovakia"},{"name":"Department of Internal Medicine, Faculty of Medicine, Pavol Jozef Safarik University in Kosice, 04011 Ko\u0161ice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Jar\u010du\u0161ka","sequence":"additional","affiliation":[{"name":"2nd Department of Internal Medicine, Louis Pasteur University Hospital, 04011 Ko\u0161ice, Slovakia"},{"name":"Department of Internal Medicine, Faculty of Medicine, Pavol Jozef Safarik University in Kosice, 04011 Ko\u0161ice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/s41575-020-00381-6","article-title":"Global epidemiology of NAFLD-related HCC: Trends, predictions, risk factors and prevention","volume":"18","author":"Huang","year":"2020","journal-title":"Nat. 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