{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T11:16:01Z","timestamp":1785928561054,"version":"3.56.0"},"reference-count":46,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T00:00:00Z","timestamp":1679875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Benign and low-grade malignant bone tumours are often treated with curettage and filling of the resultant defect using any of a number of materials, including autologous bone grafts, allografts, or synthetic materials. The objective of this study was to report our experience using a synthetic bone graft substitute in these patients. Ten consecutive cases (four males, six females; mean age, 36 years) of benign bone tumours were treated surgically at a tertiary musculoskeletal oncology centre, between 2019 and 2021. Following curettage, the contained defects were managed with injectable beta-tricalcium phosphate\/calcium sulfate (GeneX; Biocomposites Ltd., Keele, UK). The desired outcomes were early restoration of function and radiographic evidence of healing. No other graft materials were used in any of the patients. The mean follow-up was 24 months (range, 20\u201330 months). All patients in this series (100%) demonstrated radiographic evidence of healing and resumed their daily living activities. There were no tumour recurrences and no complications were encountered with the use of GeneX. In patients with contained defects following curettage of benign bone tumours, we found GeneX to be a safe and effective filling agent. These findings contrast with some existing studies that have reported local complications with the use of injectable beta-tricalcium phosphate\/calcium sulfate.<\/jats:p>","DOI":"10.3390\/curroncol30040281","type":"journal-article","created":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T04:31:21Z","timestamp":1679891481000},"page":"3697-3707","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Injectable Synthetic Beta-Tricalcium Phosphate\/Calcium Sulfate (GeneX) for the Management of Contained Defects Following Curettage of Benign Bone Tumours"],"prefix":"10.3390","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1453-9977","authenticated-orcid":false,"given":"Nima","family":"Razii","sequence":"first","affiliation":[{"name":"Department of Trauma and Orthopaedics, Glasgow Royal Infirmary, Glasgow G4 0SF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura M.","family":"Docherty","sequence":"additional","affiliation":[{"name":"Department of Trauma and Orthopaedics, Glasgow Royal Infirmary, Glasgow G4 0SF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansur","family":"Halai","sequence":"additional","affiliation":[{"name":"Division of Orthopaedic Surgery, St Michael\u2019s Hospital, University of Toronto, Toronto, ON M5C 1R6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Mahendra","sequence":"additional","affiliation":[{"name":"Department of Trauma and Orthopaedics, Glasgow Royal Infirmary, Glasgow G4 0SF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1165-6585","authenticated-orcid":false,"given":"Sanjay","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Trauma and Orthopaedics, Glasgow Royal Infirmary, Glasgow G4 0SF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1186\/s13018-019-1297-4","article-title":"Early postoperative compilations of bone filling in curettage defects","volume":"14","author":"Chen","year":"2019","journal-title":"J. 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