{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T03:36:48Z","timestamp":1793504208967,"version":"4.5.0"},"reference-count":16,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T00:00:00Z","timestamp":1680825600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Adrenocorticotropic (ACTH)-producing neuroendocrine tumours (NETs) are rarely found in the small bowel, and primary mesenteric NETs have only been reported in a few cases globally. We report the case of a 68-year-old female with ectopic Cushing\u2019s syndrome due to excessive ACTH secretion from small bowel primary lesions and mesenteric metastasis. Initially, only the mesenteric mass was detected on imaging and endoscopy\/colonoscopy, and it was only with surgical exploration that the small bowel lesions were found. This highlights the importance of high clinical suspicion and robust investigation when locating NETs. Surgical resection of the affected small bowel and mesentery was the definitive treatment for this patient. Initial hydrocortisone replacement therapy was needed, and subsequent biochemical tests and clinical reviews demonstrated no recurrence.<\/jats:p>","DOI":"10.3390\/curroncol30040312","type":"journal-article","created":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T05:57:50Z","timestamp":1681106270000},"page":"4110-4116","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A Case of Cushing\u2019s Syndrome from Well-Differentiated Neuroendocrine Tumors of the Small Bowel and Its Mesentery"],"prefix":"10.3390","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3784-2477","authenticated-orcid":false,"given":"Kirsten Rose","family":"Carlaw","sequence":"first","affiliation":[{"name":"Colorectal Surgery Department, Nepean Hospital, Kingswood, NSW 2747, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmer","family":"Hameed","sequence":"additional","affiliation":[{"name":"Colorectal Surgery Department, Nepean Hospital, Kingswood, NSW 2747, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Shakeshaft","sequence":"additional","affiliation":[{"name":"Colorectal Surgery Department, Nepean Hospital, Kingswood, NSW 2747, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1530\/EJE-19-0877","article-title":"Management of Endocrine Disease: Cushing\u2019s syndrome due to ectopic ACTH secretion: An expert operational opinion","volume":"182","author":"Young","year":"2020","journal-title":"Eur. J. Endocrinol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2407-6-108","article-title":"Ectopic Cushing\u2019 syndrome caused by a neuroendocrine carcinoma of the mesentery","volume":"6","author":"Fasshauer","year":"2006","journal-title":"BMC Cancer"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.ecl.2018.01.005","article-title":"The ectopic adrenocorticotropic hormone syndrome: Rarely easy, always challenging","volume":"47","author":"Hayers","year":"2018","journal-title":"Endocrinol. Metab. Clin. N. Am."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1038\/s41379-018-0110-y","article-title":"A common classification framework for neuroendocrine neoplasms: An International Agency for Research on Cancer (IARC) and World Health Organization (WHO) expert consensus proposal","volume":"31","author":"Rindi","year":"2018","journal-title":"J. Mod. Hum. Pathol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3231","DOI":"10.1210\/JC.2015-1589","article-title":"Conventional and nuclear medicine imaging in ectopic Cushing\u2019s syndrome: A systematic review","volume":"100","author":"Isidori","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1046\/j.1365-2265.2003.01853.x","article-title":"PET scan in occult ectopic ACTH syndrome: A useful tool?","volume":"59","author":"Biering","year":"2003","journal-title":"Clin. Endocrinol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"872","DOI":"10.2967\/jnumed.115.165803","article-title":"68 Ga-DOTATATE compared with 111In-DTPA-Octreotide and Conventional Imaging for Pulmonary and Gastroenteropancreatic Neuroendocrine Tumors: A Systematic Review and Meta-Analysis","volume":"57","author":"Deppen","year":"2016","journal-title":"J. Nucl. 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Clin Endocrin Diabetes"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1308\/003588412X13373405387492","article-title":"Ectopic Cushing\u2019s syndrome due to a mesenteric neuroendocrine tumor","volume":"94","author":"Mashoori","year":"2012","journal-title":"Ann. R. Coll. Surg. Engl."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Paun, D., Vija, L., Stan, E., Banica, A., Bobeica, E., Terzea, D., Poiana, C., Badiu, C., and Paun, S. (2015). Cushing syndrome secondary to ectopic adrenocorticotropic hormone secretion from a Meckel diverticulum neuroendocrine tumor: Case report. BMC Endocr. Disord., 15.","DOI":"10.1186\/s12902-015-0070-x"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"47","DOI":"10.4103\/jpgm.JPGM_772_16","article-title":"Ectopic adrenocorticotropic hormone syndrome in a case of duodenal neuroendocrine tumor presenting with liver metastasis","volume":"64","author":"Khare","year":"2018","journal-title":"J. Postgrad. Med."}],"container-title":["Current Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1718-7729\/30\/4\/312\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:12:04Z","timestamp":1760123524000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1718-7729\/30\/4\/312"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,7]]},"references-count":16,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,4]]}},"alternative-id":["curroncol30040312"],"URL":"https:\/\/doi.org\/10.3390\/curroncol30040312","relation":{},"ISSN":["1718-7729"],"issn-type":[{"value":"1718-7729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,7]]}}}