{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T08:03:04Z","timestamp":1793520184177,"version":"4.5.0"},"reference-count":55,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,6,25]],"date-time":"2023-06-25T00:00:00Z","timestamp":1687651200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Objective: To investigate the clinicopathological, therapeutic, and survival data on pediatric major salivary gland cancers. Materials and Methods: National Cancer Database (NCDB) query from 2004 to 2018. Results: In total, 967 cases of individuals under the age of 21 were identified. Most cancers affected the parotid gland (86%). Mucoepidermoid carcinoma (41.3%) and acinic cell adenocarcinoma (33.6%) were the most common. Tumors occurred more often from age 11 to 21, and females were more affected. Histology varied by age, gender, and race. In the 0\u20135 age group, mucoepidermoid carcinoma and myoepithelial carcinoma\/sarcoma\/rhabdomyosarcoma were the most common pathologies. In patients over 5 years old, mucoepidermoid carcinoma was the most frequent tumor in boys, while acinic cell adenocarcinoma was more common in girls. African American patients had a higher incidence of mucoepidermoid carcinoma, while White patients in the 0\u20135 age group had a higher incidence of myoepithelial carcinoma\/sarcoma\/rhabdomyosarcoma tumors. Low-grade tumors were commonly diagnosed at stage I, but the 0\u20135 age group had a high frequency of stage IV tumors. The overall 5-year survival rate was 94.9%, with 90% for the 0\u20135 years age group and 96% for the 11\u201315 years age group. Negative margins were associated with higher 5-year survival rates in high-stage tumors (93%) compared to positive margins (80%). Submandibular malignancies had worse 5-year survival rates across all age groups. Conclusions: Major salivary gland malignancies in pediatric patients exhibit variations in histopathologic characteristics by age, gender, and race. Negative margins impact 5-year survival rates, especially in high-stage tumors.<\/jats:p>","DOI":"10.3390\/curroncol30070456","type":"journal-article","created":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T05:39:13Z","timestamp":1687757953000},"page":"6134-6147","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Exploring the Epidemiology and Survival Trends in Pediatric Major Salivary Gland Malignancies: Insights from the National Cancer Database"],"prefix":"10.3390","volume":"30","author":[{"given":"Madison","family":"Coleman","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, University of Tennessee Health Science Center College of Medicine, Memphis, TN 38103, USA"},{"name":"Department of Pediatric Otolaryngology, Le Bonheur Children\u2019s Hospital, Memphis, TN 38103, USA"},{"name":"Division of Pediatric Otolaryngology, St. Jude Children\u2019s Research Hospital, Memphis, TN 38103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, St. Jude Children\u2019s Research Hospital, Memphis, TN 38103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey C.","family":"Rastatter","sequence":"additional","affiliation":[{"name":"Division of Pediatric Otolaryngology\u2013Head and Neck Surgery, Ann & Robert H. Lurie Children\u2019s Hospital of Chicago, Chicago, IL 60611, USA"},{"name":"Department of Otolaryngology-Head and Neck Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca S.","family":"Arch","sequence":"additional","affiliation":[{"name":"Division of Pediatric Otolaryngology\u2013Head and Neck Surgery, Ann & Robert H. Lurie Children\u2019s Hospital of Chicago, Chicago, IL 60611, USA"},{"name":"Department of Otolaryngology-Head and Neck Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1722-2924","authenticated-orcid":false,"given":"Jessica","family":"Gartrell","sequence":"additional","affiliation":[{"name":"Department of Oncology, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Daniel C.","family":"Chelius","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Pediatric Head and Neck Tumor Program, Baylor College of Medicine, Texas Children\u2019s Hospital, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Sheyn","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, University of Tennessee Health Science Center College of Medicine, Memphis, TN 38103, USA"},{"name":"Department of Pediatric Otolaryngology, Le Bonheur Children\u2019s Hospital, Memphis, TN 38103, USA"},{"name":"Division of Pediatric Otolaryngology, St. Jude Children\u2019s Research Hospital, Memphis, TN 38103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5624-3031","authenticated-orcid":false,"given":"Cai","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, St. Jude Children\u2019s Research Hospital, Memphis, TN 38103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0001-7879","authenticated-orcid":false,"given":"Celine","family":"Richard","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, University of Tennessee Health Science Center College of Medicine, Memphis, TN 38103, USA"},{"name":"Department of Pediatric Otolaryngology, Le Bonheur Children\u2019s Hospital, Memphis, TN 38103, USA"},{"name":"Division of Pediatric Otolaryngology, St. Jude Children\u2019s Research Hospital, Memphis, TN 38103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1002\/lary.27192","article-title":"Has the management of pediatric mucoepidermoid carcinoma of the parotid gland changed?","volume":"128","author":"Janz","year":"2018","journal-title":"Laryngoscope"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.otohns.2005.11.018","article-title":"Clinical characteristics and survival for major salivary gland malignancies in children","volume":"134","author":"Shapiro","year":"2006","journal-title":"Otolaryngol. 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