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Various investigations confirmed empirically that the dysregulation of cholesterol homeostasis positively correlates with tumor progression. More specifically, recent studies suggested the distinct role of cholesterol in ovarian cancer cell proliferation, metastasis and chemoresistance. In this review, we summarize the current findings that suggest the contribution of cholesterol homeostasis dysregulation to ovarian cancer progression and resistance to anti-cancer agents. We also discuss the therapeutic implications of cholesterol-lowering drugs in ovarian cancer.<\/jats:p>","DOI":"10.3390\/curroncol30090609","type":"journal-article","created":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T05:31:28Z","timestamp":1694583088000},"page":"8386-8400","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Dysregulation of Cholesterol Homeostasis in Ovarian Cancer"],"prefix":"10.3390","volume":"30","author":[{"given":"Zahraa","family":"Qusairy","sequence":"first","affiliation":[{"name":"Cancer Research Program, Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6848-6559","authenticated-orcid":false,"given":"Anne","family":"Gangloff","sequence":"additional","affiliation":[{"name":"CHU de Qu\u00e9bec-Universit\u00e9 Laval Research Center, Qu\u00e9bec City, QC G1V 4G2, Canada"},{"name":"Faculty of Medicine, Laval University, Qu\u00e9bec City, QC G1V 0A6, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4110-7595","authenticated-orcid":false,"given":"Shuk On Annie","family":"Leung","sequence":"additional","affiliation":[{"name":"Cancer Research Program, Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada"},{"name":"Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, McGill University Health Centre, McGill University, Montreal, QC H4A 3J1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21708","article-title":"Cancer Statistics, 2022","volume":"72","author":"Siegel","year":"2022","journal-title":"CA Cancer J. 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