{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T16:57:58Z","timestamp":1774025878302,"version":"3.50.1"},"reference-count":38,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T00:00:00Z","timestamp":1696896000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>We report on a clinical case of capecitabine-induced acute ileitis in a patient treated with pre-operative concurrent chemoradiation with capecitabine for locally advanced rectal cancer and provide a comprehensive literature review. This a rare, but life-threatening, clinical situation, that clinicians should be aware of. Severe persistent diarrhea is the most frequent clinical feature and computed tomography is a valid tool for diagnosis. Conservative management includes capecitabine withdrawal, antidiarrheal therapy and endovenous hydration, together with dietary modifications and broad-spectrum antibiotics. Pelvic irradiation represents an adjunctive risk factor, which may increase the likelihood of occurrence of terminal ileitis. Early recognition and prompt intervention are crucial for successful clinical management.<\/jats:p>","DOI":"10.3390\/curroncol30100655","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T02:20:52Z","timestamp":1696990852000},"page":"9063-9077","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Capecitabine-Induced Ileitis during Neoadjuvant Pelvic Radio-Chemotherapy for Locally Advanced Rectal Cancer: A Case Report with Literature Review"],"prefix":"10.3390","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6467-4299","authenticated-orcid":false,"given":"Andrea","family":"Brignoli","sequence":"first","affiliation":[{"name":"Division of Radiation Oncology, University Hospital \u201cMaggiore della Carit\u00e0\u201d, 28100 Novara, Italy"},{"name":"Department of Translational Medicine, University of the Eastern Piedmont, 28100 Novara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleonora","family":"Ferrara","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, University Hospital \u201cMaggiore della Carit\u00e0\u201d, 28100 Novara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4445-7428","authenticated-orcid":false,"given":"Micol","family":"Zannetti","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, University Hospital \u201cMaggiore della Carit\u00e0\u201d, 28100 Novara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianfranco","family":"Loi","sequence":"additional","affiliation":[{"name":"Department of Medical Physics, University Hospital \u201cMaggiore della Carit\u00e0\u201d, 28100 Novara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Forti","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, University Hospital \u201cMaggiore della Carit\u00e0\u201d, 28100 Novara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Socci","sequence":"additional","affiliation":[{"name":"Division of Surgery, Hospital \u2018S.S. Trinita\u2019, 28021 Borgomanero, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Carriero","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, University of the Eastern Piedmont, 28100 Novara, Italy"},{"name":"Division of Radiology, University Hospital \u201cMaggiore della Carit\u00e0\u201d, 28100 Novara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Gennari","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, University of the Eastern Piedmont, 28100 Novara, Italy"},{"name":"Division of Medical Oncology, University Hospital \u201cMaggiore della Carit\u00e0\u201d, 28100 Novara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Krengli","sequence":"additional","affiliation":[{"name":"Radiation Oncology, Veneto Institute of Oncology IOV-IRCCS, 35100 Padua, Italy"},{"name":"Department of Surgery, Oncology and Gastroenterology, University of Padova, 35100 Padua, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2276-0687","authenticated-orcid":false,"given":"Pierfrancesco","family":"Franco","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, University Hospital \u201cMaggiore della Carit\u00e0\u201d, 28100 Novara, Italy"},{"name":"Department of Translational Medicine, University of the Eastern Piedmont, 28100 Novara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. 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