{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:06:19Z","timestamp":1787162779890,"version":"build-2736575974"},"reference-count":40,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T00:00:00Z","timestamp":1698624000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ontario Association of General Surgery (OAGS)"},{"name":"Department of Surgery at Queen\u2019s University"},{"name":"Southeastern Ontario Academic Medical Organization"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Those with cirrhosis who develop colorectal cancer (CRC) are an understudied group who may tolerate treatments poorly and are at risk of worse outcomes. This is a retrospective cohort study of 842 individuals from Ontario, Canada, with a pre-existing diagnosis of cirrhosis who underwent surgery for CRC between 2009 and 2017. Practice patterns, overall survival, and short-term morbidity and mortality were assessed. The most common cirrhosis etiology was non-alcoholic fatty liver disease (NAFLD) (52%) and alcohol-associated liver disease (29%). The model for end-stage liver disease score (MELD-Na) was available in 42% (median score of 9, IQR7-11). Preoperative radiation was used in 62% of Stage II\/III rectal cancer patients, while postoperative chemotherapy was used in 42% of Stage III colon cancer patients and 38% of Stage II\/III rectal cancer patients. Ninety-day mortality following surgery was 12%. Five-year overall survival was 53% (by Stages I\u2013IV, 66%, 55%, 50%, and 11%, respectively). Those with alcohol-associated cirrhosis (HR 1.8, 95% CI 1.5\u20132.2) had lower survival than those with NAFLD. Those with a MELD-Na of 10+ did worse than those with a lower MELD-Na score (HR 1.9, 95% CI 1.4\u20132.6). This study reports poor survival in those with cirrhosis who undergo treatment for CRC. Caution should be taken when considering aggressive treatment.<\/jats:p>","DOI":"10.3390\/curroncol30110690","type":"journal-article","created":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T13:26:55Z","timestamp":1698672415000},"page":"9530-9541","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Colorectal Cancer in Individuals with Cirrhosis: A Population-Based Study Assessing Practice Patterns, Outcomes, and Predictors of Survival"],"prefix":"10.3390","volume":"30","author":[{"given":"Sunil","family":"Patel","sequence":"first","affiliation":[{"name":"Department of Surgery, Queen\u2019s University, Kingston, ON K7L 2V7, Canada"},{"name":"Cancer Care and Epidemiology, Queens Cancer Research Institute, Kingston, ON K7L 3N6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Brennan","sequence":"additional","affiliation":[{"name":"Department of Surgery, Queen\u2019s University, Kingston, ON K7L 2V7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Surgery, Ottawa University, Ottawa, ON K1H 8L6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Djerboua","sequence":"additional","affiliation":[{"name":"ICES Queens, Kingston, ON K7L 3L4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sulaiman","family":"Nanji","sequence":"additional","affiliation":[{"name":"Department of Surgery, Queen\u2019s University, Kingston, ON K7L 2V7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaila","family":"Merchant","sequence":"additional","affiliation":[{"name":"Department of Surgery, Queen\u2019s University, Kingston, ON K7L 2V7, Canada"},{"name":"Cancer Care and Epidemiology, Queens Cancer Research Institute, Kingston, ON K7L 3N6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Flemming","sequence":"additional","affiliation":[{"name":"Cancer Care and Epidemiology, Queens Cancer Research Institute, Kingston, ON K7L 3N6, Canada"},{"name":"Department of Medicine, Queen\u2019s University, Kingston, ON K7L 3N6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S2468-1253(18)30339-X","article-title":"Incidence of cirrhosis in young birth cohorts in Canada from 1997 to 2016: A retrospective population-based study","volume":"4","author":"Flemming","year":"2019","journal-title":"Lancet Gastroenterol. 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